{"id":35853,"date":"2026-05-02T17:16:14","date_gmt":"2026-05-02T16:16:14","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=35853"},"modified":"2026-05-05T19:17:43","modified_gmt":"2026-05-05T18:17:43","slug":"nigella-sativa","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/","title":{"rendered":"Cumin, black \u2013 Nigella sativa and cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-81d0cd4dd2e878ca47b04007d86fc5a0 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a867a5e69af727a1b962d2b1d75fb9e7\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Grouped_by_Effect\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\">Dietary Supplements Grouped by Effect<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Alphabetical\"><\/span><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\"><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\">Dietary Supplements Alphabetical<\/a><\/mark><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-ac57049debe0731ab13d06b9c41f2391\"><a href=\"https:\/\/jegharkraeft.dk\/en\/acai-berries-and-cancer\/\">A,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/baicalin\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">B<\/mark>,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/cats-claw-tomentosa\/\">C,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/danshen\/\">D,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/echinacea\/\">E+F,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/garcinia-cambogia\/\">G,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/hemp-seeds\/\">H,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/\">I+J+K,<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark><\/a> <a href=\"https:\/\/jegharkraeft.dk\/en\/lions-mane\/\">L,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/maitake\/\">M,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/n-acetyl-cysteine\/\">N,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/omega-3\/\">O,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/peppermint\/pebermynte\/\">P<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-interne-links-color\">,<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/quercetin\/\">Q,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/reishi\/\">R,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/selenium\/\">S,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/thc-cannabis\/\">T,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/vitamin-b\/\">U+V+Z<\/a><\/h4>\n\n\n\n<ul class=\"wp-block-list has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-f792582fd2a5fbce0e8e2429afb42ad2\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-12b488bc76fee50d91e458b757bac13f\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\"><a href=\"https:\/\/jegharkraeft.dk\/en\/baicalin\/\">Baicalin<\/a><\/mark><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-2b19627a4c5deb0bfdc6c23cdfc11fef\"><a href=\"https:\/\/jegharkraeft.dk\/en\/berberine\/\">Berberine<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-f8fe6535d2f90221e7d50901db5a887f\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bergamot\/\">Bergamot<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-59179ef12bb7c20c9e66ee945b1cb811\"><a href=\"https:\/\/jegharkraeft.dk\/en\/beta-carotene\/\">Beta Carotene<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-70635f52d30cd867989fee0f9041de4a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/betaine\/\">Betaine<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-d697ee9131896cbdb2c26156fee77b25\"><a href=\"https:\/\/jegharkraeft.dk\/en\/beta-glucan\/\">Beta glucan<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-049464b3a7b276d5a4a9ac34fa6722d0\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bifido\/\">Bifido<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-e87ff2feef413287e1adade2383405f0\"><a href=\"#https:\/\/jegharkraeft.dk\/en\/n-acetyl-cysteine\/\">Black cumin (Nigella) (scroll down)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-f4f9d72b9cf57b9a0adc985cb4ad0041\"><a href=\"https:\/\/jegharkraeft.dk\/en\/black-walnut\/\">Black Walnut<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-578d4600497ca31c01b2bddca491390b\"><a href=\"https:\/\/jegharkraeft.dk\/en\/blushwood-berry\/\">Blushwood berry<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-31ab7ea5e2e49c8cc59097d3ddf91af5\"><a href=\"https:\/\/jegharkraeft.dk\/en\/boron\/\">Boron<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-8d263a9d273cdaa95dac226dd3f80208\"><a href=\"https:\/\/jegharkraeft.dk\/en\/boswellia\/\">Boswellia\/ Frankincense<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-54c8ffe3259b9bc8647186fd078c00d5\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bromelain\/\">Bromelain<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-03f972c1ba5afac4d8ffb0c8711c4dc9\"><a href=\"https:\/\/jegharkraeft.dk\/en\/burdock-root\/\">Burdock root<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6952fb6c32cad962534459841ac051ef\"><a href=\"https:\/\/jegharkraeft.dk\/en\/butyric-acid\/\">Butyrate\/ butyric acid<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-87961980bbd4741a09273fbe14a2592f\"><a href=\"https:\/\/jegharkraeft.dk\/en\/barley-grass\/\">Barley grass<\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-a141aae0da29d0267d89e3bd69e2a683 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"650\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella.jpg\" alt=\"Nigella eller sort spidskommen illustreret ved gr\u00f8nt pilleglas fra Swanson med p\u00e5skriften Black Cumin Seed Oil.\" class=\"wp-image-35852\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella.jpg 650w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella-150x150.jpg 150w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;http:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bnigella.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 class=\"wp-block-heading\" id=\"nigella-sativa\"><span class=\"ez-toc-section\" id=\"Black_Cumin_Nigella_and_Cancer\"><\/span>Black Cumin (Nigella) and Cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h4 class=\"wp-block-heading\">What is Black Cumin or Nigella<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin, also known as <em>Nigella sativa<\/em> (black cumin seed in English), is a plant with a long history in traditional medicine, particularly in the Middle East and Asia. The seeds of the plant have been used for centuries to treat a wide range of ailments, including infections, inflammatory diseases, and digestive problems. In recent years, there has been increased focus on black cumin&#8217;s potential in relation to cancer treatment, both as a preventive and complementary treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanisms_of_Action_and_Potential_of_Nigella\"><\/span>Mechanisms of Action and Potential of Nigella<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin&#8217;s potential anti-cancer effects are primarily attributed to its content of bioactive substances, especially thymoquinone, which has been shown to have a number of pharmacological properties. Some of the proposed mechanisms of action in relation to cancer include [1, 2, 3, 4, 5]:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Induction of Apoptosis<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Apoptosis is a form of programmed cell death where the cell breaks itself down in a controlled manner. It is an important process in the body, used among other things to remove damaged or unnecessary cells. Cancer cells often have the ability to evade apoptosis, which contributes to their uncontrolled growth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Thymoquinone, the primary bioactive component in black cumin, has been shown to be able to induce apoptosis in a number of different cancer cell types. This happens through various mechanisms, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Activation of caspase enzymes: Caspases are a group of enzymes that play a central role in apoptosis. Thymoquinone can activate these enzymes, leading to the breakdown of the cell.<\/li>\n\n\n\n<li>Regulation of the Bcl-2 family of proteins: The Bcl-2 family consists of proteins that either promote or inhibit apoptosis. Thymoquinone can affect the balance between these proteins and thus promote apoptosis in cancer cells.<\/li>\n\n\n\n<li>Increased production of reactive oxygen species (ROS): ROS are molecules that can cause oxidative stress in cells. In moderate amounts, ROS can induce apoptosis in cancer cells.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Inhibition of Cell Proliferation<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Cancer cells have uncontrolled cell division, which leads to tumor growth. Black cumin has been shown to be able to inhibit cell proliferation in various cancer cell types. This can happen through various mechanisms, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Inhibition of the cell cycle: The cell cycle is a series of phases that the cell goes through when it divides. Black cumin can block the cell cycle in specific phases, e.g., the G0\/G1 phase, thus preventing cell division.<\/li>\n\n\n\n<li>Inhibition of signaling pathways: Cancer cells use various signaling pathways to regulate cell growth and division. Black cumin can inhibit these signaling pathways, e.g., PI3K\/Akt and MAPK pathways, and thus reduce cell proliferation.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Antioxidant Effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Free radicals are unstable molecules that can damage cells and DNA. Oxidative stress occurs when there is an imbalance between free radicals and the body&#8217;s antioxidant defenses. Oxidative stress can contribute to the development of cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin has antioxidant properties that can neutralize free radicals and protect cells from oxidative stress. This is primarily due to its content of thymoquinone and other antioxidant substances, such as flavonoids and polyphenols [3].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anti-inflammatory Effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Chronic inflammation is a risk factor for the development of cancer and can promote tumor growth and spread. Black cumin has been shown to have anti-inflammatory properties.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Thymoquinone and other bioactive substances in black cumin can inhibit the production of inflammatory cytokines, which are signaling molecules that promote inflammation. This can potentially limit inflammation in the tumor microenvironment and inhibit tumor growth [2, 3].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Immunostimulating Effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The immune system plays an important role in fighting cancer cells. Black cumin can potentially increase the activity of the immune system and thus improve the body&#8217;s ability to fight cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studies have shown that black cumin can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Increase the activity of natural killer cells (NK cells): NK cells are a type of immune cell that can directly kill cancer cells.<\/li>\n\n\n\n<li>Increase the production of cytokines: Cytokines are signaling molecules that regulate the immune response. Some cytokines can promote the immune system&#8217;s activity against cancer cells.<\/li>\n\n\n\n<li>Stimulate phagocytosis: Phagocytosis is a process where immune cells engulf and destroy cancer cells.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Inhibition of Angiogenesis<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Angiogenesis is the formation of new blood vessels, which is crucial for tumor growth and metastasis. Cancer tumors require a constant supply of blood to grow and spread.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin has been shown to be able to inhibit angiogenesis in various cancer models. This can happen by:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Inhibiting the production of growth factors: Growth factors are signaling molecules that stimulate the formation of new blood vessels. Black cumin can inhibit the production of growth factors, e.g., VEGF (vascular endothelial growth factor).<\/li>\n\n\n\n<li>Inhibiting migration and proliferation of endothelial cells: Endothelial cells are cells that form blood vessels. Black cumin can inhibit migration and proliferation of endothelial cells, which prevents the formation of new blood vessels.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Benefits_of_Black_Cumin\"><\/span>Benefits of Black Cumin<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Antioxidant and Anti-inflammatory Effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Can contribute to protecting the body from damage caused by free radicals and inflammation. See mechanisms of action above.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Potential Synergistic Effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin can potentially enhance the effect of conventional cancer treatment, such as chemotherapy and radiation therapy.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Improved Quality of Life<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin can potentially alleviate some of the side effects of cancer and cancer treatment, such as nausea, fatigue, and pain.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Disadvantages_and_Limitations\"><\/span>Disadvantages and Limitations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Limited Clinical Evidence<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">There is a need for more and larger clinical studies to confirm the preclinical findings and establish the optimal dosage and use of black cumin in cancer treatment.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Interactions with Medication<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin can potentially interact with certain types of medication, including blood-thinning medications and immunosuppressive medications.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Side Effects<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Although black cumin is generally well tolerated, it can cause side effects in some people, such as digestive problems, allergic reactions, and skin rashes.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Not a Replacement for Other Cancer Treatment<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin should not be used as a replacement for conventional cancer treatment, but can be used as a supplement in consultation with a qualified healthcare provider.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Preclinical_and_Clinical_Studies\"><\/span>Preclinical and Clinical Studies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin has been shown to have a number of potential anti-cancer effects in preclinical studies. These effects are primarily due to its content of bioactive substances, especially thymoquinone, which can affect various processes in cancer cells and the tumor microenvironment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">A number of preclinical studies (in vitro and in vivo) have shown promising results indicating that black cumin may have anti-cancer effects against various cancer types, including breast cancer, lung cancer, prostate cancer, colon cancer, and leukemia. However, there is limited clinical evidence for the effect in humans with cancer [1, 2, 3, 4, 5, 9, 10, 11].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is thus a need for more research, including clinical studies with humans, to confirm these findings and establish the optimal dosage and use of black cumin in cancer treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dispensing_and_Intake\"><\/span>Dispensing and Intake<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin is available in various forms, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Seeds: Can be chewed, ground into powder, or used in cooking.<\/li>\n\n\n\n<li>Oil: Can be taken orally or used topically (applied to the skin).<\/li>\n\n\n\n<li>Dietary supplement: Available in capsule form.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">General Dosage Recommendations<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">According to studies, black cumin oil has most often been used by adults in doses of 1-2.5 grams orally daily for 4-12 weeks. Black cumin powder has most often been used in doses of 1-2 grams orally daily for 8-12 weeks. One teaspoon of oil typically corresponds to about 5 ml, which weighs approximately 4.5-5 grams.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to follow the recommendations on the product and consult a qualified healthcare provider before starting black cumin, especially if you are taking other medication or have a chronic illness.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Potential Side Effects<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Although black cumin oil is generally considered safe in small amounts (such as in cooking) and in the doses studied for up to 3 months, as mentioned above, there can be side effects. These can include digestive problems (nausea, bloating, constipation), and in rare cases allergic reactions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are also some precautions regarding interactions with medications (e.g., blood-thinning medications, medications for high blood pressure and diabetes) and certain medical conditions.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Toxicity<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Studies have generally found that black cumin oil has low toxicity at normal doses. High doses in animal studies have shown signs of toxicity, but there is limited research in humans at very high doses over longer periods.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin is a natural product with potential as a complementary treatment for cancer. There is evidence that it may have anti-cancer effects, but there is a need for more research to confirm these findings and establish the optimal dosage and use. (However, this is unlikely to happen, as there is no financial interest from drug manufacturers in this, since the product cannot be patented).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Black cumin should always be used in consultation with a competent healthcare provider, as it can interact with medications and cause side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"nigella-sativa\">Back to <a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\" target=\"_blank\" rel=\"noreferrer noopener\">Supplements<\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-9190cfe395c28e4d2ec89873338ddaa5 wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e65d7a14504f4ff6ce7af1ece7bac8ed wp-block-paragraph\">[1] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37948309\/\" target=\"_blank\" rel=\"noreferrer noopener\">HDAC inhibition by Nigella sativa L. sprouts extract in hepatocellular carcinoma: an approach to study anti-cancer potential<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: In vitro study investigating the anti-cancer potential of Nigella sativa sprouts extract through HDAC inhibition in hepatocellular carcinoma, demonstrating its ability to modulate epigenetic mechanisms and induce apoptosis in liver cancer cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3e2aee71791896426fe6f8bdc3fa2fb8 wp-block-paragraph\">[2] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39206985\/\" target=\"_blank\" rel=\"noreferrer noopener\">The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations<\/a> (PubMed, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Combined in vitro and in vivo study examining thymoquinone&#8217;s anti-cancer effects on small cell lung cancer, showing its potential to inhibit tumor growth and induce cell death through multiple signaling pathways.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-5e97c6f66033c762d59de5254d5d973b wp-block-paragraph\">[3] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39124928\/\" target=\"_blank\" rel=\"noreferrer noopener\">Turmeric-Black Cumin Essential Oils and Their Capacity to Attenuate Free Radicals, Protein Denaturation, and Cancer Proliferation<\/a> (PubMed, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: In vitro study evaluating the antioxidant and anti-cancer properties of turmeric and black cumin essential oils, demonstrating their ability to neutralize free radicals, prevent protein denaturation, and inhibit cancer cell proliferation.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3547f2f460acb2257b3641a47d6c671f wp-block-paragraph\">[4] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39769996\/\" target=\"_blank\" rel=\"noreferrer noopener\">Molecular Mechanisms and Signaling Pathways Underlying the Therapeutic Potential of Thymoquinone Against Colorectal Cancer<\/a> (PubMed, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Review article summarizing the molecular mechanisms and signaling pathways through which thymoquinone exerts its therapeutic potential against colorectal cancer, including its effects on apoptosis, cell cycle arrest, and anti-inflammatory pathways.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8491dac0c418a86479ccffb85c4b9c17 wp-block-paragraph\">[5] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38794187\/\" target=\"_blank\" rel=\"noreferrer noopener\">Network Pharmacology and Experimental Validation to Explore the Potential Mechanism of Nigella sativa for the Treatment of Breast Cancer<\/a> (PubMed, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: In vitro and in vivo study using network pharmacology and experimental validation to explore how Nigella sativa and its active compound thymoquinone may treat breast cancer through multi-target mechanisms.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-25a39432669f024f06c4f23994f05128 wp-block-paragraph\">[6] <a href=\"https:\/\/sund-forskning.dk\/artikler\/en-rejse-gennem-kroppen-med-den-sorte-kommenolie\/\" target=\"_blank\" rel=\"noreferrer noopener\">En rejse gennem kroppen med den sorte kommenolie<\/a> (Sund Forskning, 2017) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Danish article providing an overview of black cumin oil&#8217;s journey through the body and its potential health benefits, including its traditional uses and modern research. (Danish Language)<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-a46c6696945519eeaf530ea216bda728 wp-block-paragraph\">[7] <a href=\"https:\/\/www.naturamedica.dk\/sortkommen-olie-nigella-sativa-viser-effektivitet-mod-brystkraeft\/\" target=\"_blank\" rel=\"noreferrer noopener\">Sortkommen olie (Nigella Sativa) viser effektivitet mod brystkr\u00e6ft<\/a> (Naturamedica, 2017) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Danish article discussing the effectiveness of black cumin oil (Nigella sativa) against breast cancer, summarizing research findings and traditional applications. (Danish Language)<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1da2b3b6c4df7cc23bb83ee5e5287210 wp-block-paragraph\">[8] <a href=\"https:\/\/helsenyt.com\/nigella-sativas-kraefthaemmende-aktivitet\/\" target=\"_blank\" rel=\"noreferrer noopener\">Kan nigellafr\u00f8 medvirke til at h\u00e6mme udviklingen af kr\u00e6ft?<\/a> (Helsenyt, 2011) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Danish article exploring whether nigella seeds can help inhibit the development of cancer, presenting research on its anti-cancer properties. (Danish Language)<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-12caf95e7b6e3d74e613fb0647660a5c wp-block-paragraph\">[9] <a href=\"https:\/\/biomedres.us\/pdfs\/BJSTR.MS.ID.008660.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Nigella Sativa use for the Treatment of Cancer<\/a> (BioMedical, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Review article discussing the use of Nigella sativa in cancer treatment, summarizing its active compounds, mechanisms of action, and potential therapeutic applications across various cancer types.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-68e9dc38891af3fa4fab8690c5414e29 wp-block-paragraph\">[10] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38197611\/\" target=\"_blank\" rel=\"noreferrer noopener\">An investigation into the usage of black cumin derivatives against cancer and COVID-19 as the nature medicine<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Review article investigating the use of black cumin derivatives against cancer, exploring their pharmacological properties and potential as natural medicines.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-719821f81fea0d3e15ffa1ff992774c1 wp-block-paragraph\">[11] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/22083982\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anticancer activity of Nigella sativa (black seed) &#8211; a review<\/a> (PubMed, 2011) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Review article summarizing the anticancer activity of Nigella sativa, including its mechanisms of action, active compounds, and potential therapeutic applications in cancer prevention and treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ab7bc3f4d71274053b73ae2f5614af4c wp-block-paragraph\"><strong>Page created:<\/strong> January 14, 2025, Last revised May 13, 2025<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on &#8220;Jeg har Kr\u00e6ft&#8221; is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Dietary_Supplements_Grouped_by_Effect\" >Dietary Supplements Grouped by Effect<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Dietary_Supplements_Alphabetical\" >Dietary Supplements Alphabetical<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Black_Cumin_Nigella_and_Cancer\" >Black Cumin (Nigella) and Cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Mechanisms_of_Action_and_Potential_of_Nigella\" >Mechanisms of Action and Potential of Nigella<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Benefits_of_Black_Cumin\" >Benefits of Black Cumin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Disadvantages_and_Limitations\" >Disadvantages and Limitations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Preclinical_and_Clinical_Studies\" >Preclinical and Clinical Studies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Dispensing_and_Intake\" >Dispensing and Intake<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/nigella-sativa\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dietary Supplements Grouped by Effect Dietary Supplements Alphabetical A,. B,. C,. D,. E+F,. G,. H,. I+J+K,. L,. M,. N,. O,. P,. Q,. R,. S,. T,. U+V+Z Black Cumin (Nigella) and Cancer What is Black Cumin or Nigella Black cumin, also known as Nigella sativa (black cumin seed in English), is a plant with a long [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":35852,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[389,375,374],"tags":[],"class_list":["post-35853","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements","category-alternative-treatments","category-treatments"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35853","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=35853"}],"version-history":[{"count":3,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35853\/revisions"}],"predecessor-version":[{"id":36437,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35853\/revisions\/36437"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/35852"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=35853"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=35853"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=35853"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}