{"id":35523,"date":"2026-04-30T15:47:06","date_gmt":"2026-04-30T14:47:06","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=35523"},"modified":"2026-04-30T19:54:28","modified_gmt":"2026-04-30T18:54:28","slug":"indol-3-carbinol","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/","title":{"rendered":"Indol-3-carbinol and cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-3bba22b8e2525c2d13be68dd8c3b9519 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a867a5e69af727a1b962d2b1d75fb9e7\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Grouped_by_Effect\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\">Dietary Supplements Grouped by Effect<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Alphabetical\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\">Dietary Supplements Alphabetical<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-07b4cffc43faba0fb5db802cb3ccddba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/acai-berries-and-cancer\/\">A,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/baicalin\/\">B,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/cats-claw-tomentosa\/\">C,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/danshen\/\">D,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/echinacea\/\">E+F,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/garcinia-cambogia\/\">G,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/hemp-seeds\/\">H,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">I+J+K<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-interne-links-color\"><a href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/\">,<\/a><\/mark><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/lions-mane\/\">L,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/maitake\/\">M,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/n-acetyl-cysteine\/\">N,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/omega-3\/\">O,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/peppermint\/pebermynte\/\">P<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-interne-links-color\">,<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/quercetin\/\">Q,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/reishi\/\">R,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/selenium\/\">S,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/thc-cannabis\/\">T,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/vitamin-b\/\">U+V+Z<\/a><\/h4>\n\n\n\n<ul class=\"wp-block-list has-custom-hvid-tekst-color has-text-color has-link-color wp-elements-5ce9f7e786efc0bde4aeb77360a30626\">\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-8495933f5fb9e9b508603c15798caa26\"><a href=\"#indol-3-carbinol\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\">Indole-3-carbinol<\/mark> (scroll down)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-3f9b516c9f4aed3e6889cd0b3d1ae8df\"><a href=\"https:\/\/jegharkraeft.dk\/en\/inositol\/\">Inositol<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-532ca12a24e4810541cd0b48f7f7dc0a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/ip6-inositol\/\">IP6 &#8211; Inositol Hexaphosphate Phytic Acid<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-785de7c7f8f06f6984a1ea1d2aa65c0d\"><a href=\"https:\/\/jegharkraeft.dk\/en\/iodine\/\">Iodine<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-84b9aaa337af5b577cb8f5b1d11f48e6\"><a href=\"https:\/\/jegharkraeft.dk\/en\/krill-oil\/\">Krill oil<\/a><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"800\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol.jpg\" alt=\"Indol-3-carbinol symboliseret ved gr\u00f8nt pilleglas fra Swanson p\u00e5 p\u00e5skriften Indole-3-Carbinol with Resveratrol, Cellular Health.\" class=\"wp-image-8103\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol.jpg 800w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol-768x768.jpg 768w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/04\/Indol-3-carbinol.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 class=\"wp-block-heading\" id=\"indol-3-carbinol\"><span class=\"ez-toc-section\" id=\"Indole-3-carbinol_and_cancer\"><\/span>Indole-3-carbinol and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h4 class=\"wp-block-heading\">What is Indole-3-carbinol<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol (I3C) is a natural compound found in cruciferous vegetables such as broccoli, cabbage, and cauliflower. It is a derivative of the amino acid tryptophan and is formed when these vegetables are broken down during digestion. I3C has been studied for its potential health benefits, especially regarding cancer prevention and hormonal balance. It is believed to regulate estrogen metabolism and promote apoptosis in cancer cells. Due to these properties, I3C has become popular as a dietary supplement and a natural treatment in complementary medicine.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">History<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol (I3C) has historically been used in traditional medicine, particularly in cultures that have valued cruciferous vegetables for their health benefits. I3C was first identified in the 1970s when researchers began investigating the beneficial effects of components in these vegetables, particularly in relation to hormonal balance and cancer prevention. Traditionally, the consumption of cabbage and broccoli has been associated with lower risks of certain cancers, leading to an increasing interest in I3C as a natural treatment option.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanisms_of_action\"><\/span>Mechanisms of action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol works through several mechanisms that make it a potent candidate as a supplementary treatment for cancer.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Estrogen metabolism<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most significant mechanisms is the regulation of estrogen metabolism. When I3C is ingested, it is converted in the stomach into diindolylmethane (DIM), which helps balance estrogen metabolism. This can reduce the risk of estrogen-related cancers such as breast and prostate cancer.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Apoptosis<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">I3C can also stimulate apoptosis, a process where cancer cells are programmed to die. This occurs by activating specific signaling pathways related to cell cycle regulation. Additionally, I3C has anti-inflammatory properties that can reduce inflammation in the body, an important factor in many types of cancer.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Angiogenesis inhibitor<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Another important mechanism is the inhibition of angiogenesis, which is the formation of new blood vessels. By limiting the blood supply to tumors, I3C can inhibit their growth and spread.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potential_as_a_supplementary_treatment_for_cancer\"><\/span>Potential as a supplementary treatment for cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Prevention<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol&#8217;s potential as a supplementary treatment for cancer is significant. Research has shown that I3C can be beneficial in the prevention of certain types of cancer, especially those related to hormonal imbalances. Regular intake of I3C may be associated with a lower risk of breast and prostate cancer.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Supplement to conventional treatment<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, some studies show that I3C can improve the effectiveness of conventional cancer treatment by increasing the sensitivity of cancer cells to chemotherapy, which can lead to better treatment outcomes. I3C&#8217;s ability to modulate multiple signaling pathways involved in cancer cell survival can be an important factor here.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Reducing the risk of metastasis<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Moreover, research shows that I3C can protect against metastasis, which is when cancer cells spread to other parts of the body. I3C&#8217;s influence on apoptosis and the cell cycle can be crucial in preventing this spread.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_of_Indole-3-carbinol\"><\/span>Advantages of Indole-3-carbinol<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Natural compound<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol offers many advantages as a supplementary treatment for cancer. First and foremost, I3C is a natural compound found in commonly available foods, making it easy to include in the diet. It is generally well-tolerated with few reported side effects, making it a safe option.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anti-inflammatory and antioxidant<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Another advantage of I3C is its multifunctional nature. In addition to having cancer-inhibiting effects, I3C also possesses anti-inflammatory and antioxidant properties that can contribute to overall health. This is particularly important during cancer treatment, as the immune system is often weakened.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Strengthens gut flora<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, I3C can help improve gut flora, which is essential for a well-functioning immune system and thus a better ability to fight diseases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Disadvantages_and_limitations\"><\/span>Disadvantages and limitations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Although Indole-3-carbinol has many advantages, there are also disadvantages. I3C can interact with certain medications, especially those metabolized by the liver. It is important to be aware of potential interactions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, the effect of I3C is dependent on dosage and individual response, meaning that not everyone will experience the same results.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-og-kemoterapi\/\">Dietary Supplements and Chemo &#8211; Interactions<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Clinical_studies\"><\/span>Clinical studies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Several clinical studies have investigated the effect of I3C on cancer treatment. Some studies have shown promising results regarding I3C&#8217;s ability to reduce tumor growth and improve response to conventional treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For example, investigations have indicated that I3C can be effective in treating breast and prostate cancer by modulating hormonal signals and promoting apoptosis in cancer cells. Further research is necessary to confirm these results and establish optimal dosages.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Safety\"><\/span>Safety<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol is generally considered safe for most people when consumed in moderate amounts as part of a diet rich in cruciferous vegetables.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, side effects can occur, especially at high doses in the form of dietary supplements. These can include stomach upset and headaches. It is therefore a good idea to follow recommended dosages and consult a practitioner before use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dispensing_and_application\"><\/span>Dispensing and application<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol is available in various forms, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Dietary supplements<\/strong>: Available in capsules or tablets, often in concentrated doses.<\/li>\n\n\n\n<li><strong>Foods<\/strong>: Can be ingested through a diet rich in cruciferous vegetables like broccoli, cabbage, and cauliflower.<\/li>\n\n\n\n<li><strong>Capsules<\/strong>: A practical way to get a concentrated dose that is easy to take.<\/li>\n\n\n\n<li><strong>Powder<\/strong>: Can be added to smoothies or other beverages for easy ingestion and dietary variation.<\/li>\n\n\n\n<li><strong>Diet<\/strong>: Ingestion of cruciferous vegetables like broccoli, cabbage, and cauliflower as part of a healthy diet.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">It is recommended to follow the dosage instructions on the product and to include I3C as part of a balanced diet for optimal health.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Foods rich in indole-3-carbinol<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mustard greens<\/li>\n\n\n\n<li>Broccoli<\/li>\n\n\n\n<li>Cauliflower<\/li>\n\n\n\n<li>Brussels sprouts<\/li>\n\n\n\n<li>Bok choy<\/li>\n\n\n\n<li>Kale<\/li>\n\n\n\n<li>Cabbage<\/li>\n\n\n\n<li>Pointed cabbage<\/li>\n\n\n\n<li>Savoy cabbage<\/li>\n\n\n\n<li>Radishes<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Indole-3-carbinol is a promising natural compound with potential as a supplementary treatment for cancer. Its ability to regulate estrogen levels, promote apoptosis, and inhibit tumor growth makes it an interesting option for those wishing to support their treatment with natural means.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Although more research is needed to establish the most effective applications and dosages, existing studies show that I3C can play an important role in cancer prevention and treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Back to <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\">Dietary supplements<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-og-kemoterapi\/\">Dietary Supplements and Chemotherapy &#8211; Interactions<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/nutrition-and-diet-in-cancer\/\">Nutrition and Diet as a Strategy<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/dim\/\">DIM (Diindolylmethane)<\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-8492a083666d2238d3af6256c0f1e55c wp-block-paragraph\"><a target=\"_blank\" rel=\"noreferrer noopener\" href=\"\">(to menu)<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d7332c5b27f80a4995ab8941e1f3910e wp-block-paragraph\">[1]\u00a0<a href=\"https:\/\/bedrelivsstil.dk\/indol-3-carbinol-egenskaber-fordele\/\" target=\"_blank\" rel=\"noreferrer noopener\">Indol-3-carbinol: Egenskaber og fordele<\/a>\u00a0(BedreLivsstil, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article describing the properties and health benefits of indole-3-carbinol, including its role as an antioxidant and anti-inflammatory agent.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3880af7b58f3dc7fa2a5a2eeb4708b8b wp-block-paragraph\">[2]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40094833\/\" target=\"_blank\" rel=\"noreferrer noopener\">Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A comprehensive review of the pharmacological actions of I3C and DIM, focusing on their multi-targeted effects and therapeutic potential.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4a0d635e656d03ee64087535d10ff39c wp-block-paragraph\">[3]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39985695\/\" target=\"_blank\" rel=\"noreferrer noopener\">Indole-3-carbinol prevented tumor progression and potentiated PD1ab therapy by upregulating PTEN in colorectal cancer<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study demonstrating that I3C inhibits colorectal cancer progression and enhances the efficacy of immunotherapy by upregulating the PTEN gene.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-f62afe5956a04352c038d20cd26a0067 wp-block-paragraph\">[4]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39904853\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dietary phytochemical indole-3-carbinol regulates metabolic reprogramming in mouse prostate tissue<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research showing that I3C regulates metabolic reprogramming in prostate tissue, which may contribute to its chemopreventive effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b78048b7f3f5b4f5de180f9ec68ce841 wp-block-paragraph\">[5]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39726346\/\" target=\"_blank\" rel=\"noreferrer noopener\">Glucosinolates and Their Hydrolytic Derivatives: Promising Phytochemicals With Anticancer Potential<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An overview of glucosinolates and derivatives like I3C as promising phytochemicals with anticancer potential.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-5f346366a03581922786a2db8e936545 wp-block-paragraph\">[6]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39388997\/\" target=\"_blank\" rel=\"noreferrer noopener\">Indole-3-carbinol and its main derivative 3,3\u2032-diindolylmethane: Regulatory roles and therapeutic potential in liver diseases<\/a>\u00a0(PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A review of the regulatory roles and therapeutic potential of I3C and DIM in various liver diseases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-cb82ca4cdc6c2d206e737633b07b444b wp-block-paragraph\">[7]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39339278\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Aryl Hydrocarbon Receptor and Its Crosstalk: A Chemopreventive Target of Naturally Occurring and Modified Phytochemicals<\/a>\u00a0(PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study on the aryl hydrocarbon receptor as a target for chemoprevention by phytochemicals like I3C.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-40d123022481bdece1f7ac9f2ff233d7 wp-block-paragraph\">[8]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39382485\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cruciferous Plant Extracts, Their Isothyocianate or Indol Derivatives, and Their Effect on Cellular Viability of Breast Cancer Cell Lines<\/a>\u00a0(PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research investigating the effects of cruciferous plant extracts and derivatives like I3C on the viability of breast cancer cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8c5ee86d11dff4499c37c3712e58caef wp-block-paragraph\">[9]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40318812\/\" target=\"_blank\" rel=\"noreferrer noopener\">Integrating structure-activity relationships, computational approaches, and experimental validation to unlock the therapeutic potential of indole-3-carbinol and its derivatives<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A review detailing the potential for I3C in cancer prevention and treatment, emphasizing its potential in combination therapies and future development through computational analysis.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ded8ee958e5c6f45cb039ce2b928ac34 wp-block-paragraph\">[10]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40476854\/\" target=\"_blank\" rel=\"noreferrer noopener\">Treatment Interventions for Usual-Type Vulvar Intraepithelial Neoplasia: A Systematic Review and Meta-analysis<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review and meta-analysis of treatment interventions for vulvar intraepithelial neoplasia, discussing medical and surgical options.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-27fc2ea23bdf2f09f2d199a2446c7386 wp-block-paragraph\">[11]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40215823\/\" target=\"_blank\" rel=\"noreferrer noopener\">Indole-3-carbinol inhibits PD-L1-mediated immune evasion in hepatocellular carcinoma via suppressing NF-\u03baB p105 Ubiquitination<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study showing that I3C inhibits immune evasion in liver cancer by targeting specific signaling pathways, offering new possibilities for immunotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-322bd3fb2ffe4da6038adad470536db2 wp-block-paragraph\">[12]\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39985695\/\" target=\"_blank\" rel=\"noreferrer noopener\">Indole-3-carbinol prevented tumor progression and potentiated PD1ab therapy by upregulating PTEN in colorectal cancer<\/a>\u00a0(PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study demonstrating that I3C inhibits colorectal cancer growth and enhances the effect of immunotherapy, making it a promising candidate for treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3923a5cc696557d3c5a6a78a8775f18f wp-block-paragraph\" id=\"indol-3-carbinol\"><strong>Page created:<\/strong> Apr 14, 2025. Last revised: Jun 09, 2025.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Dietary_Supplements_Grouped_by_Effect\" >Dietary Supplements Grouped by Effect<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Dietary_Supplements_Alphabetical\" >Dietary Supplements Alphabetical<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Indole-3-carbinol_and_cancer\" >Indole-3-carbinol and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Mechanisms_of_action\" >Mechanisms of action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Potential_as_a_supplementary_treatment_for_cancer\" >Potential as a supplementary treatment for cancer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Advantages_of_Indole-3-carbinol\" >Advantages of Indole-3-carbinol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Disadvantages_and_limitations\" >Disadvantages and limitations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Clinical_studies\" >Clinical studies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Safety\" >Safety<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Dispensing_and_application\" >Dispensing and application<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dietary Supplements Grouped by Effect Dietary Supplements Alphabetical A,. B,. C,. D,. E+F,. G,. H,. I+J+K,. L,. M,. N,. O,. P,. Q,. R,. S,. T,. U+V+Z Indole-3-carbinol and cancer What is Indole-3-carbinol Indole-3-carbinol (I3C) is a natural compound found in cruciferous vegetables such as broccoli, cabbage, and cauliflower. It is a derivative of the amino [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":35522,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[389,375,374],"tags":[],"class_list":["post-35523","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements","category-alternative-treatments","category-treatments"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35523","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=35523"}],"version-history":[{"count":13,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35523\/revisions"}],"predecessor-version":[{"id":35663,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35523\/revisions\/35663"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/35522"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=35523"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=35523"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=35523"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}