{"id":35172,"date":"2026-04-28T18:52:59","date_gmt":"2026-04-28T17:52:59","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=35172"},"modified":"2026-05-02T18:46:50","modified_gmt":"2026-05-02T17:46:50","slug":"guarana","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/guarana\/","title":{"rendered":"Guarana and cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-d3359225ea9ba9033e77fcecb638394e has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a867a5e69af727a1b962d2b1d75fb9e7\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Grouped_by_Effect\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\">Dietary Supplements Grouped by Effect<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Alphabetical\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\">Dietary Supplements Alphabetical<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-de0bd8a38f678f8dc9737859b5549bc6\"><a href=\"https:\/\/jegharkraeft.dk\/en\/acai-berries-and-cancer\/\">A,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/baicalin\/\">B,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/cats-claw-tomentosa\/\">C,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/danshen\/\">D,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/echinacea\/\">E+F,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/garcinia-cambogia\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">G<\/mark>,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/hemp-seeds\/\">H,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/\">I+J<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-int-link-p-sort-1-color\">+K,<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/lions-mane\/\">L,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/maitake\/\">M,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/n-acetyl-cysteine\/\">N,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/omega-3\/\">O,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/peppermint\/\">P<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-interne-links-color\">,<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/quercetin\/\">Q,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/reishi\/\">R,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/selenium\/\">S,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/thc-cannabis\/\">T,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/vitamin-b\/\">U+V+Z<\/a><\/h4>\n\n\n\n<ul class=\"wp-block-list has-custom-hvid-tekst-color has-text-color has-link-color wp-elements-dd44d469d6ac7f01429dfe77be8fb0d8\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-49880e6e93de36dc72b180de07ec52e5\"><a href=\"https:\/\/jegharkraeft.dk\/en\/reishi\/\">Ganoderma lucidum, Reishi mushroom<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-eb0c4efc6c22c9813dc3a2f3c868ceee\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\"><a href=\"https:\/\/jegharkraeft.dk\/en\/garcinia-cambogia\/\">Garcinia Cambogia<\/a><\/mark><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7a86a79cadcab506af747a26168ef715\"><a href=\"https:\/\/jegharkraeft.dk\/en\/garlic\/\">Garlic<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-e476c034f13c84c002fa1683f5f774bb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/genistein\/\">Genistein<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9d5c10b6a4f0c306a23cea0f8f25baee\"><a href=\"https:\/\/jegharkraeft.dk\/en\/ginkgo-biloba\/\">Ginkgo Biloba<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-2a5fb09785bbc1c3eab08bfb72be4e0c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/ginseng\/\">Ginseng, Panax<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-71201dfc516144579068a59b7ccd4c23\"><a href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/\">Glucomannan<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-0c72ce3158f803f29e92fca69fa1067b\"><a href=\"https:\/\/jegharkraeft.dk\/en\/glucosamine-sulfate\/\">Glucosamine sulfate<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-371f1c1d9b4222e694a762eded7959a3\"><a href=\"https:\/\/jegharkraeft.dk\/en\/l-glutamine\/\">Glutamine<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-e5da140276ee9d79b4af5c8e158243cd\"><a href=\"https:\/\/jegharkraeft.dk\/en\/glutathione\/\">Glutathione<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-16d3103e6378b389a850ae43bc259f09\"><a href=\"https:\/\/jegharkraeft.dk\/en\/opc-grape-seed-extract\/\">Grape seed extract OPC<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-24caa7df52850f81d27bdd8373fdc0bf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/graviola\/\">Graviola<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-30e25450a9486cd2936520347f37bf0a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/egcg\/\">Green tea (EGCG)<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-e2c0f089b8db3dd119eff9fffe0634f8\"><a href=\"#guarana\">Guarana (scroll down)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-00cb2a8c1db95fe2b4634148536b93b5\"><a href=\"https:\/\/jegharkraeft.dk\/en\/gymnema-sylvestre\/\">Gymnema sylvestre<\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-a141aae0da29d0267d89e3bd69e2a683 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"650\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1.jpg\" alt=\"Guarana symboliseret ved gr\u00f8nt pilleglas fra Swanson med p\u00e5skriften Guarana, Energy Support.\" class=\"wp-image-35161\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1.jpg 650w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1-150x150.jpg 150w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Guarana1.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 class=\"wp-block-heading\" id=\"guarana\"><span class=\"ez-toc-section\" id=\"Guarana_and_cancer\"><\/span>Guarana and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Summary of guarana<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Effect:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Guarana is a plant that contains caffeine, theobromine, and antioxidants. it primarily acts as a stimulant that increases energy and mental alertness by blocking fatigue-inducing substances in the brain. Simultaneously, its antioxidants protect the body&#8217;s cells from damage.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Potential in cancer:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Laboratory studies have shown that guarana can inhibit the growth of cancer cells and cause them to die [6, 7]. Clinically, its most documented effect is alleviating the debilitating fatigue many experience during chemo- and radiation therapy, which can significantly improve quality of life [1, 4].<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main limitation:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The primary limitation is that cancer-inhibiting effects have not yet been confirmed in large human studies. Furthermore, the high caffeine content can cause side effects such as insomnia and palpitations and interact with certain types of medication.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Recap:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Guarana is a promising supplement that can especially help combat the debilitating fatigue accompanying cancer treatment. While test-tube research suggests direct cancer-fighting properties, more research is awaited before its full potential can be established.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_is_guarana\"><\/span>What is guarana<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12.jpeg\" alt=\"Guarana symboliseret ved del af planten med r\u00f8de b\u00e6r og gr\u00f8nne blade.\" class=\"wp-image-14307\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana12-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana (<em>Paullinia cupana<\/em>) is a climbing plant originating from the Amazon rainforest in Brazil. The plant is especially known for its fruits, which contain seeds with a remarkably high concentration of active substances. When the fruit is ripe, it opens to reveal a black seed surrounded by white pulp, giving it a characteristic appearance resembling an eye.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is primarily the seeds that are used. They are dried, roasted, and ground into a fine powder. This powder forms the basis for the guarana extracts and supplements used today. Guarana is rich in a group of alkaloids called methylxanthines, which include caffeine, theobromine, and theophylline. In fact, guarana seeds contain between 2% and 8% caffeine, which is up to four times more than coffee beans.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In addition to these stimulants, guarana also contains a wealth of other bioactive components, including tannins, saponins, and a range of polyphenols such as catechins, epicatechins, and procyanidins. This complex composition is believed to create a synergistic effect where the different substances work together to enhance each other&#8217;s impact.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">History<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana has a long and rich history, especially among the indigenous people of the Amazon, such as the Sater\u00e9-Maw\u00e9 tribe, who considered the plant sacred. For centuries, they have used guarana as a tonic for energy and endurance, particularly during long hunting trips, where it helped them suppress hunger and fight fatigue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Traditionally, the crushed seeds were mixed with water to make a paste, which was then rolled into logs and dried. This paste could subsequently be grated and dissolved in hot or cold water to make a drink. Beyond the stimulating effect, guarana was also used in traditional medicine to treat various ailments, including headaches, fever, and diarrhea. It was only in the 20th century that guarana became commercially widespread, primarily as a key ingredient in popular Brazilian soft drinks and later in global energy drinks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanisms_of_action\"><\/span>Mechanisms of action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8.jpeg\" alt=\"Guarana symboliseret ved planche med menneske med krans af forskellige frugter og b\u00e6r omkring. og lidt af indvoldene vist.\" class=\"wp-image-14311\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana8-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana&#8217;s effects on the body are complex and due to the interplay between its many active substances. The most well-studied components are the methylxanthines, but polyphenols and saponins also play a crucial role in its health potential.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">The role of methylxanthines<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The dominant mechanism of action comes from caffeine. Caffeine primarily works by blocking adenosine receptors in the central nervous system. Adenosine is a neurotransmitter that promotes relaxation and sleepiness. By blocking adenosine&#8217;s effect, caffeine increases alertness and reduces fatigue.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This also leads to an increased release of other neurotransmitters such as dopamine and norepinephrine, which can improve mood, reaction time, and cognitive function. Tannins in guarana are believed to cause the caffeine to be released more slowly in the body, providing a more even and long-lasting energy boost compared to the rapid effect of coffee.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Antioxidant and anti-inflammatory activity<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana is a powerful source of antioxidants, especially due to its high content of polyphenols like catechins and proanthocyanidins [3, 5]. These substances are capable of neutralizing free radicals\u2014unstable molecules that can cause cell damage (oxidative stress) by damaging DNA, proteins, and cell membranes. Chronic oxidative stress is a contributing factor to the development of many chronic diseases, including cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Multiple studies have shown that guarana&#8217;s antioxidant capacity is significant [3]. By protecting cells from oxidative damage, guarana could theoretically help prevent the mutations that lead to cancer. Furthermore, these polyphenols have anti-inflammatory properties, inhibiting inflammatory signaling pathways such as NF-\u03baB, which regulates immune responses to infection and inflammation [5].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See more about signaling pathways here: <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/jegharkraeft.dk\/en\/kraeftens-signalveje\/\">Block cancer signaling pathways<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Impact_on_cellular_signaling_pathways\"><\/span>Impact on cellular signaling pathways<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Recent research, primarily <em>in vitro<\/em> (in test tubes\/petri dishes), has shown that guarana can affect specific signaling pathways crucial for cancer cell survival and growth.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Inhibition of the AKT\/mTOR pathway<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most interesting mechanisms is guarana&#8217;s ability to inhibit the AKT\/mTOR pathway [7]. This pathway is often overactive in many cancers and acts as a central regulator for cell growth and survival. By blocking proteins like AKT and mTOR, guarana can prevent cancer cells from dividing uncontrollably.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Modulation of the MAPK pathway<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The MAPK (Mitogen-Activated Protein Kinase) pathway is another important route regulating cell proliferation and apoptosis (programmed cell death). Research indicates that guarana can modulate this pathway, potentially disrupting the mechanisms cancer cells rely on to grow and spread [7].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potential_in_cancer\"><\/span>Potential in cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20.png\" alt=\"Guarana symboliseret ved en m\u00f8rk celle der \u00f8del\u00e6gges af frugter der angriber den. M\u00f8rk baggrund.\" class=\"wp-image-14312\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana20-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana&#8217;s potential as a supplementary agent in cancer treatment is multifaceted and supported by a growing amount of preclinical research [6].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Induction of apoptosis and inhibition of proliferation<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most promising properties of guarana is its ability to induce apoptosis\u2014programmed cell death. Cancer cells are characterized by their ability to evade apoptosis. <em>In vitro<\/em> studies have shown that guarana extract can cause cancer cells to undergo apoptosis by affecting the balance of proteins in the Bcl-2 family [5, 6]. At the same time, guarana inhibits the proliferation of cancer cells, markedly reducing cell growth in breast and lung cancer models [6, 7].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Anti-metastatic and anti-angiogenic properties<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Metastasis, the spread of cancer cells, is the primary cause of death in cancer patients. Preliminary studies suggest that guarana may have anti-metastatic properties, reducing the formation of lung metastases in melanoma models.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Angiogenesis is the process where tumors form new blood vessels to secure oxygen and nutrients. Guarana&#8217;s anti-inflammatory and signaling pathway-modulating properties suggest it may have the potential to inhibit this process, potentially &#8220;starving&#8221; the tumor [3].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Alleviating cancer-related fatigue<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most well-documented and clinically relevant uses of guarana is for the relief of cancer-related fatigue (CRF). A meta-analysis concluded that guarana provides a significant improvement in CRF compared to placebo [1, 4]. The stimulating effect of caffeine, combined with other bioactive substances, is believed to improve energy levels and mental clarity without the sharp fluctuations often associated with pure caffeine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_of_guarana\"><\/span>Advantages of guarana<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4.png\" alt=\"Guarana symboliseret ved En lilla celle der bliver angrebet af guarana som sm\u00e5 kugler. bl\u00e5 baggrund.\" class=\"wp-image-14316\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana4-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Beyond direct cancer-related potential, guarana offers general health benefits beneficial for those undergoing cancer treatment.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Improved cognitive function and mental clarity<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">&#8220;Chemobrain,&#8221; a condition involving cognitive challenges like memory loss and lack of concentration, is a known side effect of chemotherapy. Guarana&#8217;s caffeine and bioactive compounds have been shown to improve cognitive functions such as memory and attention.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Support for weight control and metabolism<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Unwanted weight changes can be a challenge during treatment. Research suggests guarana can influence metabolism, increasing calorie burn and promoting fat breakdown. It may also help prevent certain metabolic disturbances like insulin resistance.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Protection of healthy cells<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana&#8217;s powerful antioxidant properties help protect healthy cells from damage resulting from both the cancer itself and conventional treatments like chemo- and radiotherapy [3, 5]. By strengthening the body&#8217;s own antioxidant defense, guarana can potentially reduce some of this damage.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Disadvantages_and_limitations\"><\/span>Disadvantages and limitations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14.jpeg\" alt=\"Guarana symboliseret ved planche af del af planten med r\u00f8de b\u00e6r og f\u00e5 blade. r\u00f8d baggrund. og nogle runde forklarende cirkler rundt om dette.\" class=\"wp-image-14305\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana14-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">While guarana shows great potential, there are important limitations. Most research on its cancer-inhibiting properties has been conducted <em>in vitro<\/em> or in animal models [6, 7]. Although promising, these results cannot be directly applied to humans without large, well-controlled clinical trials.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, guarana can interact with certain medications. The stimulant effect can enhance other stimulants, and its potential mild blood-thinning effect may pose a risk when combined with anticoagulant medication.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Elaboration_on_medication_interactions\"><\/span>Elaboration on medication interactions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10.jpeg\" alt=\"Guarana symboliseret ved en planche med plantedele, frugter, en oversk\u00e5ret frugt med det sorte fr\u00f8 og en flaske med guarana i midten. Lysgr\u00e5 baggrund.\" class=\"wp-image-14309\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana10-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana&#8217;s high caffeine content means it can affect how certain drugs work in the body.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Interaction with stimulants<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana&#8217;s energizing effect primarily comes from caffeine. When combined with other stimulant medications, the overall effect can become too powerful, leading to palpitations, high blood pressure, nervousness, and insomnia. Examples include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>ADHD medication:<\/strong> Drugs like methylphenidate (Ritalin) and amphetamines (Adderall).<\/li>\n\n\n\n<li><strong>Cold and asthma remedies:<\/strong> Drugs containing ephedrine or pseudoephedrine, and theophylline.<\/li>\n\n\n\n<li><strong>Other caffeine sources:<\/strong> Coffee, tea, and energy drinks.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Interaction with blood thinners<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana may have a mild blood-thinning effect by inhibiting platelet aggregation. When combined with clinical blood thinners, it increases the risk of bleeding. Examples include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Anticoagulants:<\/strong> Warfarin (Marevan), apixaban (Eliquis), rivaroxaban (Xarelto).<\/li>\n\n\n\n<li><strong>Antiplatelet drugs:<\/strong> Clopidogrel (Plavix), aspirin (Hjertemagnyl).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Other potential interactions<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Lithium:<\/strong> Caffeine can increase the body&#8217;s excretion of lithium, potentially decreasing the medication&#8217;s effect.<\/li>\n\n\n\n<li><strong>Certain antidepressants (MAOIs):<\/strong> Combining MAOIs with high amounts of caffeine can theoretically lead to dangerous blood pressure spikes.<\/li>\n\n\n\n<li><strong>Liver enzymes:<\/strong> Caffeine is broken down by the enzyme CYP1A2. Medications that inhibit this enzyme (like ciprofloxacin or fluvoxamine) can increase caffeine levels and side effect risks.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Clinical_studies\"><\/span>Clinical studies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6.png\" alt=\"Guarana symboliseret ved Planche med menneske og forskellige organer vist ved siden af. med lidt tekst under.\" class=\"wp-image-14314\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana6-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Clinical studies on guarana in a cancer context have almost exclusively focused on alleviating side effects, particularly fatigue [1, 4]. Pilot studies on breast cancer patients receiving chemotherapy showed significant improvement in fatigue scores in the group receiving guarana compared to the placebo group. Similar positive results were found in patients with various solid tumors [1].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While these results support the use of guarana against fatigue, larger and more robust clinical trials are needed to validate these findings and investigate any direct impact on the cancer itself in humans.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Safety\"><\/span>Safety<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7.png\" alt=\"Guarana symboliseret ved del af planten med r\u00f8de b\u00e6r og et skjold foran for at vise sikkerhed. M\u00f8rk baggrund.\" class=\"wp-image-14313\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana7-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana is generally considered safe in moderate amounts. Side effects are typically mild and caffeine-related, such as jitteriness or insomnia.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, caution is required for individuals with cardiovascular disease, high blood pressure, anxiety disorders, or gastric ulcers, as the stimulant effect can exacerbate these conditions. Due to its potential effect on blood clotting, guarana should be avoided in the weeks leading up to surgery. Always inform your practitioner about your use of guarana during an active cancer journey.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dispensing_and_application\"><\/span>Dispensing and application<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a.png\" alt=\"Guarana symboliseret ved brunt pipetteflaske, lille bunke brunt pulver og nogle brune kapsler. Turkis baggrund.\" class=\"wp-image-14330\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana3a-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Powder:<\/strong> The most traditional form. Can be mixed into water, juice, or smoothies. A typical dose is 500 mg to 1000 mg (1 gram) once or twice daily.<\/li>\n\n\n\n<li><strong>Capsules\/Tablets:<\/strong> An easy way to take a standardized dose, typically containing 200 mg to 500 mg of extract.<\/li>\n\n\n\n<li><strong>Liquid extract\/Tincture:<\/strong> Concentrated drops that can be added to liquids.<\/li>\n\n\n\n<li><strong>Energy drinks\/bars:<\/strong> Common but often high in sugar; the amount of guarana may be unclear.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">It is recommended to consume guarana early in the day to avoid sleep interference.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17.jpeg\" alt=\"Guarana symboliseret ved tegning af planten med r\u00f8de b\u00e6r. Forklarende tekst, man dog ikke umiddelbart kan l\u00e6se.\" class=\"wp-image-14302\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/guarana17-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Guarana is a fascinating natural product with a complex biochemical profile. Its potential in cancer treatment is promising, especially for combating cancer-related fatigue and improving quality of life [1, 4]. Preclinical research also indicates direct cancer-inhibiting properties by inducing cell death and inhibiting central growth pathways [6, 7].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While the current clinical evidence primarily supports its use against side effects, laboratory studies point toward an as-yet-unclarified potential as a direct cancer-fighting supplement.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"guarana\">Back to <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\">Dietary supplements<\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-9190cfe395c28e4d2ec89873338ddaa5 wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d82ac1a7a05607c916c78c9f57ae0385 wp-block-paragraph\">[1] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39536249\/\" target=\"_blank\" rel=\"noreferrer noopener\">Natural supplementation to effectively treat cancer-induced fatigue: evidence of a meta-analysis on the use of guaran\u00e1<\/a> (PubMed, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A meta-analysis supporting the use of guarana to treat cancer-related fatigue, though calling for larger randomized controlled trials.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dc2d859baf9c08b1e2d3a171cecfa9d3 wp-block-paragraph\">[2] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40124017\/\" target=\"_blank\" rel=\"noreferrer noopener\">Deciphering Steroidal and Aporphine Alkaloids as Antileukemic Agents by Approaches of Molecular Networking and Metabolomics<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research suggesting that fruits like guarana can help regulate cell growth and influence molecular biomarkers, supporting their potential as natural anticancer agents.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2f5530bfc730bb63c00b11c62932460e wp-block-paragraph\">[3] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34571077\/\" target=\"_blank\" rel=\"noreferrer noopener\">Ethnopharmacological evaluation of antioxidant, anti-angiogenic, and anti-inflammatory activity of some traditional medicinal plants used for treatment of cancer in Togo\/Africa<\/a> (PubMed, 2022) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study showing guarana extract has strong antioxidant and anti-angiogenic effects, reducing blood vessel formation while remaining safe for human blood cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-a91f74065345a368cf50545868f2e054 wp-block-paragraph\">[4] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37327641\/\" target=\"_blank\" rel=\"noreferrer noopener\">Should patients with acute myeloid leukemia treated with venetoclax-based regimens receive antifungal prophylaxis?<\/a> (PubMed, 2023) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Reference to meta-analyses supporting guarana for cancer-related fatigue.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e51336508c06101611af12f043f6b9fe wp-block-paragraph\">[5] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36168017\/\" target=\"_blank\" rel=\"noreferrer noopener\">Paullinia cupana seed extract ameliorated methotrexate-induced testicular dysfunction through the regulation of antioxidants, inflammatory, apoptosis\/anti-apoptosis, and steroidogenesis-associated genes<\/a> (PubMed, 2023) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research showing guarana protects against oxidative stress and DNA damage caused by specific chemotherapy agents like methotrexate.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-54159d8add00f1e362b06a0b0e178cfa wp-block-paragraph\">[6] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36461205\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer<\/a> (PubMed, 2022) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Study showing that guarana can contribute to lung cancer treatment by promoting apoptosis and reducing tumor growth.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-5c8acdae12d90e7187b573592d0ed24f wp-block-paragraph\">[7] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35400408\/\" target=\"_blank\" rel=\"noreferrer noopener\">Signaling pathways and the potential anticarcinogenic effect of native Brazilian fruits on breast cancer<\/a> (PubMed, 2022) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research highlighting that guarana can help fight breast cancer by inhibiting cancer cell survival pathways and regulating the growth cycle.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2387a07b17e487730a927ae4c74322b2 wp-block-paragraph\"><strong>Page created:<\/strong> Jun 28, 2025. Last revised: Apr 28, 2026.<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Dietary_Supplements_Grouped_by_Effect\" >Dietary Supplements Grouped by Effect<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Dietary_Supplements_Alphabetical\" >Dietary Supplements Alphabetical<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Guarana_and_cancer\" >Guarana and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#What_is_guarana\" >What is guarana<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Mechanisms_of_action\" >Mechanisms of action<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Impact_on_cellular_signaling_pathways\" >Impact on cellular signaling pathways<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Potential_in_cancer\" >Potential in cancer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Advantages_of_guarana\" >Advantages of guarana<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Disadvantages_and_limitations\" >Disadvantages and limitations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Elaboration_on_medication_interactions\" >Elaboration on medication interactions<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Clinical_studies\" >Clinical studies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Safety\" >Safety<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Dispensing_and_application\" >Dispensing and application<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/jegharkraeft.dk\/en\/guarana\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dietary Supplements Grouped by Effect Dietary Supplements Alphabetical A,. B,. C,. D,. E+F,. G,. H,. I+J+K,. L,. M,. N,. O,. P,. Q,. R,. S,. T,. U+V+Z Guarana and cancer Summary of guarana Effect: Potential in cancer: Main limitation: Recap: What is guarana Guarana (Paullinia cupana) is a climbing plant originating from the Amazon rainforest in [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":35161,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[389,375,374],"tags":[],"class_list":["post-35172","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-supplements","category-alternative-treatments","category-treatments"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35172","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=35172"}],"version-history":[{"count":4,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35172\/revisions"}],"predecessor-version":[{"id":35942,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35172\/revisions\/35942"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/35161"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=35172"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=35172"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=35172"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}