{"id":35080,"date":"2026-04-28T15:04:18","date_gmt":"2026-04-28T14:04:18","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=35080"},"modified":"2026-05-02T18:45:42","modified_gmt":"2026-05-02T17:45:42","slug":"glucomannan","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/glucomannan\/","title":{"rendered":"Glucomannan and cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-8fdb119baec11eb346fc8134d4f7ce17 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a867a5e69af727a1b962d2b1d75fb9e7\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Grouped_by_Effect\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\">Dietary Supplements Grouped by Effect<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dietary_Supplements_Alphabetical\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\">Dietary Supplements Alphabetical<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-de0bd8a38f678f8dc9737859b5549bc6\"><a href=\"https:\/\/jegharkraeft.dk\/en\/acai-berries-and-cancer\/\">A,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/baicalin\/\">B,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/cats-claw-tomentosa\/\">C,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/danshen\/\">D,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/echinacea\/\">E+F,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/garcinia-cambogia\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">G<\/mark>,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/hemp-seeds\/\">H,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/indol-3-carbinol\/\">I+J<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-int-link-p-sort-1-color\">+K,<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/lions-mane\/\">L,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/maitake\/\">M,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/n-acetyl-cysteine\/\">N,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/omega-3\/\">O,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/peppermint\/\">P<mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-interne-links-color\">,<\/mark><\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/quercetin\/\">Q,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/reishi\/\">R,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/selenium\/\">S,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/thc-cannabis\/\">T,<\/a><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-sort-tekst-color\">.<\/mark> <a href=\"https:\/\/jegharkraeft.dk\/en\/vitamin-b\/\">U+V+Z<\/a><\/h4>\n\n\n\n<ul class=\"wp-block-list has-custom-hvid-tekst-color has-text-color has-link-color wp-elements-4eb30608b8106e00ed272eff3c2d7ed2\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-49880e6e93de36dc72b180de07ec52e5\"><a href=\"https:\/\/jegharkraeft.dk\/en\/reishi\/\">Ganoderma lucidum, Reishi mushroom<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-eb0c4efc6c22c9813dc3a2f3c868ceee\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\"><a href=\"https:\/\/jegharkraeft.dk\/en\/garcinia-cambogia\/\">Garcinia Cambogia<\/a><\/mark><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7a86a79cadcab506af747a26168ef715\"><a href=\"https:\/\/jegharkraeft.dk\/en\/garlic\/\">Garlic<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-e476c034f13c84c002fa1683f5f774bb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/genistein\/\">Genistein<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9d5c10b6a4f0c306a23cea0f8f25baee\"><a href=\"https:\/\/jegharkraeft.dk\/en\/ginkgo-biloba\/\">Ginkgo Biloba<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-2a5fb09785bbc1c3eab08bfb72be4e0c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/ginseng\/\">Ginseng, Panax<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-2e43d41accd68b77ed718024ae937709\"><a href=\"#glucomannan\">Glucomannan (scroll down)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-0c72ce3158f803f29e92fca69fa1067b\"><a href=\"https:\/\/jegharkraeft.dk\/en\/glucosamine-sulfate\/\">Glucosamine sulfate<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-371f1c1d9b4222e694a762eded7959a3\"><a href=\"https:\/\/jegharkraeft.dk\/en\/l-glutamine\/\">Glutamine<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-e5da140276ee9d79b4af5c8e158243cd\"><a href=\"https:\/\/jegharkraeft.dk\/en\/glutathione\/\">Glutathione<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-16d3103e6378b389a850ae43bc259f09\"><a href=\"https:\/\/jegharkraeft.dk\/en\/opc-grape-seed-extract\/\">Grape seed extract OPC<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-24caa7df52850f81d27bdd8373fdc0bf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/graviola\/\">Graviola<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-30e25450a9486cd2936520347f37bf0a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/egcg\/\">Green tea (EGCG)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-3cbe783ecfe1590c065147962be96960\"><a href=\"https:\/\/jegharkraeft.dk\/en\/?p=35172\">Guarana<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-00cb2a8c1db95fe2b4634148536b93b5\"><a href=\"https:\/\/jegharkraeft.dk\/en\/gymnema-sylvestre\/\">Gymnema sylvestre<\/a><\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-a141aae0da29d0267d89e3bd69e2a683 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\"><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"650\" height=\"650\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1.jpg\" alt=\"Glucomannan symboliseret ved et gr\u00f8nt pilleglas fra Swanson med p\u00e5skriften Glucomannan, Digestive Health.\" class=\"wp-image-35070\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1.jpg 650w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1-150x150.jpg 150w\" sizes=\"auto, (max-width: 650px) 100vw, 650px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan1.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 class=\"wp-block-heading\" id=\"glucomannan\"><span class=\"ez-toc-section\" id=\"Glucomannan_and_cancer\"><\/span>Glucomannan and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Summary of glucomannan<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Effect:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Effect:<\/strong> A water-soluble fiber that forms a gel in the stomach. The gel provides satiety and ensures stable blood sugar levels [6]. In the intestine, the fiber acts as food for beneficial gut bacteria, which in turn produce beneficial substances that strengthen the intestinal wall and help against constipation.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Potential in cancer:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The potential lies in creating a healthy intestinal environment [3]. Beneficial substances formed by gut bacteria have shown in laboratory experiments the ability to inhibit cancer cells in the intestine [1]. Simultaneously, a healthier gut will reduce inflammation in the body and strengthen the immune system, which is a significant advantage during a cancer journey [4, 7].<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main limitation:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Must always be consumed with plenty of water to avoid blockage in the esophagus or intestine. It can also reduce and delay the absorption of medication, which should therefore be taken at other times.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Recap:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Glucomannan is an effective fiber supplement for supporting digestion and blood sugar. In a cancer context, it is a valuable tool for strengthening the body&#8217;s foundation via a healthy gut, but it is a supportive treatment and not a cure.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_is_glucomannan\"><\/span>What is glucomannan<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23.png\" alt=\"Glucomannan symboliseret ved planche af farvet tegning af plante med rod og blade. et par tekster p\u00e5 hvid baggrund.\" class=\"wp-image-14252\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan23-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Glucomannan is a water-soluble dietary fiber extracted from the root of the konjac plant (<em>Amorphophallus konjac<\/em>), which grows in Asia [6]. Its most notable property is an exceptional ability to absorb water and form a thick, viscous gel. A small amount of glucomannan can bind a large amount of liquid, which is central to many of its effects in the body.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Due to this property, it is often used as a dietary supplement to promote satiety and support weight regulation, improve digestion, and regulate blood sugar and cholesterol levels [6]. As a prebiotic fiber, it passes undigested through the upper part of the gastrointestinal tract and is then fermented by beneficial bacteria in the large intestine [3]. This process is crucial for its health-promoting potential.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">History<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The konjac root, and thus glucomannan, has a long history in traditional Japanese, Chinese, and Southeast Asian cultures spanning more than 1,500 years [6]. Originally, it was valued for its medicinal properties, where in traditional Chinese medicine it was used for detoxification, relief of asthma, cough, hernia, and skin disorders.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Culinary-wise, the konjac root has been a staple for centuries, processed into products like konjac flour, jelly, and the well-known shirataki noodles. These foods were not only eaten for their unique texture but also for their perceived health benefits, including &#8220;cleansing&#8221; the system.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Scientific interest in isolated glucomannan fibers is more recent, driven by a growing understanding of the importance of dietary fibers and gut flora for human health.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanisms_of_action\"><\/span>Mechanisms of action<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21.png\" alt=\"Glucomannan symboliseret ved planche der viser tarms p\u00e5virkning ved indtag af glucomannan. hudfarvede tegninger. hvid baggrund.\" class=\"wp-image-14254\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan21-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The mechanisms of action for glucomannan are complex and involve both physical and biochemical processes, primarily centered in the gastrointestinal tract. These mechanisms work together to create a range of positive effects in the body.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Physical effect and satiety<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">When glucomannan is consumed with plenty of water, it swells in the stomach and forms a viscous gel. This gel significantly increases the volume of the stomach contents, thereby delaying gastric emptying. The result is a sustained feeling of satiety and fullness, which can contribute to reducing overall calorie intake. This mechanism is particularly beneficial for maintaining a healthy weight, an important factor during a cancer journey.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Prebiotic effect and production of short-chain fatty acids<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Glucomannan functions as an ideal prebiotic. Since it cannot be broken down by human enzymes, it reaches the large intestine intact [3]. Here, it becomes a nutrient source for beneficial gut bacteria such as <em>Bifidobacterium<\/em> and <em>Lactobacillus<\/em>. Through a fermentation process, these bacteria convert the fiber into a range of bioactive substances, including short-chain fatty acids (SCFAs). The three primary SCFAs are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Butyrate (butyric acid):<\/strong> Considered the most important SCFA for gut health.<\/li>\n\n\n\n<li><strong>Acetate (acetic acid):<\/strong> Absorbed and used as energy in various tissues.<\/li>\n\n\n\n<li><strong>Propionate (propionic acid):<\/strong> Plays a role in the liver&#8217;s sugar and fat metabolism.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/jegharkraeft.dk\/en\/bifido\/\">Lactic acid bacteria<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">The central role of butyrate<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The remarkable thing about butyrate is its almost intelligent &#8220;dual role&#8221; in the gut. For the healthy cells that make up the intestinal wall, it acts as pure super-fuel, keeping them healthy and strong.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">However, when butyrate encounters a cancer cell, the opposite happens. Instead of providing nourishment, it acts as a key that restarts the cancer cell&#8217;s forgotten &#8220;self-destruction program&#8221; [4].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Imagine that all cells in the body have a built-in safety manual. One of the most important instructions in this manual is: &#8220;Destroy yourself if you develop into a cancer cell.&#8221; Cancer cells survive precisely because they have found a way to ignore or &#8220;turn off&#8221; this vital instruction.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Butyrate&#8217;s ability is to penetrate the cancer cell and &#8220;turn on&#8221; this safety instruction again. Thus, the cancer cell is forced to obey the body&#8217;s original command and perish. In this way, butyrate assists the body&#8217;s own internal defense against cancer [1, 7].<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Potential_in_cancer\"><\/span>Potential in cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2.jpeg\" alt=\"Glucomannan symboliseret ved planche af mands overkrop, med symbolser ved siden der skal vise virkning i kroppen.\" class=\"wp-image-14250\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan2-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Glucomannan&#8217;s potential as a supplementary treatment in cancer is not related to a direct &#8220;cure,&#8221; but rather its ability to strengthen the body&#8217;s own defense, improve the gut environment, and counteract some of the negative processes associated with cancer and its treatment [1, 3].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Support for the gut ecosystem<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">A healthy gut environment is fundamental to a well-functioning immune system. Cancer treatments such as chemotherapy and radiation therapy can disrupt the delicate balance of the gut flora and weaken the intestinal barrier. By promoting the growth of beneficial bacteria and the production of butyrate, glucomannan helps restore this balance [1, 6].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This can strengthen the gut&#8217;s barrier function and reduce the amount of pro-inflammatory substances circulating in the body. A lower degree of systemic inflammation creates a less favorable environment for cancer cells to grow and spread [2].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Inhibition of cancer cells in the colon<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">As mentioned, butyrate is a key factor. Increased butyrate production via glucomannan fermentation has shown significant potential in preclinical studies (laboratory and animal studies). <em>In vitro<\/em> (in test tubes\/petri dishes), butyrate has demonstrated the ability to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Induce apoptosis:<\/strong> Activate signals that cause colon cancer cells to commit suicide [5, 7].<\/li>\n\n\n\n<li><strong>Inhibit proliferation:<\/strong> Stop uncontrolled cell division [1].<\/li>\n\n\n\n<li><strong>Promote differentiation:<\/strong> Cause cancer cells to mature and behave more like normal cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Although these results are primarily from the laboratory, they suggest that a high-fiber diet maximizing butyrate production can be an important strategy in the prevention and supportive treatment of colorectal cancer [1, 3].<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Improved immune response<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Gut flora and produced SCFAs play a crucial role in &#8220;educating&#8221; and modulating the immune system. A healthy microbiome can improve the function of immune cells such as T-cells and natural killer (NK) cells, which are vital for recognizing and eliminating cancer cells [4]. Research suggests that a robust gut flora can even improve the efficacy of certain types of immunotherapy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_of_glucomannan\"><\/span>Advantages of glucomannan<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19.png\" alt=\"Glucomannan symboliseret ved oversk\u00e5ret celle i gr\u00f8nne toner med nogle lilla enheder deri. hvid baggrund. forklarende tekst omkring.\" class=\"wp-image-14256\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan19-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Beyond its direct potential related to cancer processes, glucomannan offers several general benefits that can significantly improve the quality of life for individuals during cancer treatment.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Regulation of digestion<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Constipation is a common and distressing side effect of certain types of chemotherapy as well as pain medication like opioids. Glucomannan&#8217;s ability to bind water and increase stool volume and softness makes it an effective and natural remedy for constipation [6].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Regular and well-functioning digestion is essential for general well-being and the body&#8217;s ability to excrete waste products.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/jegharkraeft.dk\/en\/forstoppelse-diarre-kemo\/\">Constipation or diarrhea<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Stabilization of blood sugar<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Certain cancer treatments, especially steroids like prednisone, can lead to elevated blood sugar. Glucomannan&#8217;s gel-forming property delays the absorption of carbohydrates from the gut, leading to a more gradual and stable increase in blood sugar after meals [6].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This can help prevent significant blood sugar fluctuations and support better metabolic balance.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Support for cardiovascular health<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Glucomannan has a well-documented ability to lower total cholesterol and especially &#8220;bad&#8221; LDL cholesterol [6]. It works by binding to bile acids in the gut and excreting them. The liver must then produce new bile acids using cholesterol from the bloodstream, thereby lowering levels. Maintaining good cardiovascular health is important for overall resilience.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Disadvantages_and_limitations\"><\/span>Disadvantages and limitations<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7.jpeg\" alt=\"Glucomannan symboliseret ved en rosa planche med en central cellelignende figur og en masse symboler omkring denne.\" class=\"wp-image-14245\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan7-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">While glucomannan is generally safe, there are important precautions and potential disadvantages to be aware of.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Risk of obstruction<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The greatest risk with glucomannan is related to its strong water-absorbing capacity. If consumed in powder or capsule form without sufficient liquid, it can swell and create a blockage in the esophagus or further down the intestinal tract. This is a serious condition requiring immediate attention. It is therefore paramount always to consume glucomannan with large amounts of water.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Gastrointestinal discomfort<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Particularly at the beginning, glucomannan can cause mild digestive issues such as bloating, gas, or diarrhea. This is because the gut flora must adapt to the increased amount of fermentable fiber. These symptoms are usually temporary and can be minimized by starting with a low dose and gradually increasing it.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Interaction with medication and nutrients<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">The gel formed by glucomannan can delay or reduce the body&#8217;s absorption of oral medication and other supplements [2]. This is especially important to note during a cancer journey, where accurate and timely absorption of medication is critical. As a general rule, glucomannan should be taken at least one hour before or four hours after taking any form of medication, including, for example, diabetes medications like sulfonylureas, as the combination may otherwise lead to low blood sugar.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Clinical_studies\"><\/span>Clinical studies<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13.jpeg\" alt=\"Glucomannan symboliseret ved farvede kugler der symboliserer molekylestrukturen. Lilla baggrund.\" class=\"wp-image-14239\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan13-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Clinical research on glucomannan has primarily focused on its effects on weight, cholesterol, blood sugar, and constipation, where results are generally positive and well-substantiated [6]. Meta-analyses of randomized, controlled trials confirm that glucomannan can effectively lower LDL cholesterol, improve blood sugar control, and promote weight loss.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Direct clinical studies of glucomannan&#8217;s effect on cancer in humans are limited. Current knowledge about its potential in cancer stems mainly from <em>in vitro<\/em> studies (on cells in the lab) and <em>in vivo<\/em> studies (in living organisms, typically animals), investigating the effects of the SCFAs produced during fermentation [1, 5, 7].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">While these preclinical studies are promising, especially for colon cancer, more human studies are needed to confirm these effects and establish optimal doses in a clinical context. However, there are studies confirming its positive effect on treatment-related constipation in cancer patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Safety\"><\/span>Safety<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a.png\" alt=\"Glucomannan symboliseret ved 2 klare glas med vand. Det ene er der ved at komme en skefuld pulver ned i. Det andet er v\u00e6sken blevet til en gel\u00e9-masse. Lysbl\u00e5 baggrund.\" class=\"wp-image-14268\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan17a-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">When used correctly, glucomannan is considered a safe supplement for most adults. It is recognized as &#8220;Generally Recognized As Safe&#8221; (GRAS) by the U.S. Food and Drug Administration (FDA) when consumed as part of food.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The primary safety precautions are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fluid intake:<\/strong> Always take glucomannan with plenty of water (at least 1-2 large glasses) to avoid choking hazards or intestinal blockage.<\/li>\n\n\n\n<li><strong>Medication timing:<\/strong> Respect the time window of at least 1 hour before or 4 hours after taking medication.<\/li>\n\n\n\n<li><strong>Gradual start:<\/strong> Start with a low dose to let the digestive system adapt and avoid mild side effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">People with swallowing difficulties or known narrowing of the esophagus or intestine should consult their practitioner before using glucomannan.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Dispensing_and_application\"><\/span>Dispensing and application<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a.png\" alt=\"Glucomannan symboliseret ved hvidt pilleglas der ligger ned med et par kapsler uden for det \u00e5bne glas. Ved siden af et glas med pulver. Lilla baggrund.\" class=\"wp-image-14267\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/glucomannan35a-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">To achieve the best results and ensure correct use, it is important to follow instructions carefully.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Form:<\/strong> Glucomannan is typically available as a powder or in capsules. The powder can be mixed directly into water or other liquid, while capsules are easier to dose and consume. The powder often works faster as it dissolves immediately.<\/li>\n\n\n\n<li><strong>Dosage:<\/strong> A typical dosage is 1 gram (approx. 1\/2 teaspoon powder or 1-2 capsules) taken three times daily. It is wise to start with a lower dose, e.g., 0.5-1 gram once daily, and gradually increase the amount.<\/li>\n\n\n\n<li><strong>Timing:<\/strong> To achieve effects on satiety and blood sugar, glucomannan should be taken 15 to 60 minutes before a meal.<\/li>\n\n\n\n<li><strong>Consumption:<\/strong> <strong>Regardless of the form, it must always be consumed with at least one large glass of water (250 ml), preferably two.<\/strong> This is crucial for activating the fiber and preventing obstruction.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"960\" height=\"960\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8.jpeg\" alt=\"Glucomannan symboliseret ved samling af celler i kugleform i midten og andre celler omkring denne. beige baggrund.\" class=\"wp-image-14244\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8.jpeg 960w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8-300x300.jpeg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8-100x100.jpeg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8-600x600.jpeg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8-150x150.jpeg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/06\/Glucomannan8-768x768.jpeg 768w\" sizes=\"auto, (max-width: 960px) 100vw, 960px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Glucomannan is a multifunctional prebiotic supplement with a solid scientific basis for its positive effects on digestion, blood sugar control, and cholesterol levels [6].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Its potential as supplementary support in a cancer journey is significant, primarily through its ability to optimize gut health [3]. By nourishing a beneficial gut flora and increasing the production of the anti-inflammatory and cell-protective short-chain fatty acid butyrate, glucomannan can contribute to strengthening the body&#8217;s resilience, reducing systemic inflammation, and creating a more robust foundation for healing [1, 2].<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is not a treatment in itself, but a valuable tool for improving quality of life and supporting the body&#8217;s own defense mechanisms, especially when used correctly and with the necessary precautions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\" id=\"glucomannan\">Back to <a target=\"_blank\" rel=\"noreferrer noopener\" href=\"https:\/\/jegharkraeft.dk\/en\/kosttilskud-grupperet\/\">Dietary supplements<\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-9190cfe395c28e4d2ec89873338ddaa5 wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/supplements-alphabetically\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-9233a5ab6008b69111b031b5fefc5250 wp-block-paragraph\">[1] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40528838\/\" target=\"_blank\" rel=\"noreferrer noopener\">Synergistic ROS\/enzyme dual-responsive oral drug delivery system: A novel multi-mechanistic platform for spatiotemporal control and overcoming drug resistance in colorectal cancer therapy<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research developed a system with konjac glucomannan (KGM)-based microspheres that release medication specifically in the gut using ROS and enzyme responsiveness. The system inhibits tumor growth, reduces inflammation, and restores gut flora, strengthening the immune system and improving treatment against colorectal cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1d75ccc223430e3a3eb57cdabba93e04 wp-block-paragraph\">[2] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40516724\/\" target=\"_blank\" rel=\"noreferrer noopener\">Natural macromolecules polysaccharide-based drug delivery systems targeting tumor necrosis factor alpha receptor for the treatment of cancer: A review<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This article reviews the potential of natural macromolecules like konjac glucomannan, chitosan, and other polysaccharides in targeted cancer treatments. These biocompatible substances are used in advanced drug delivery systems to improve stability, control release, and target treatment toward the tumor necrosis factor-alpha receptor, which can reduce toxicity and overcome resistance.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-81fedab0731b916bb676381cc96a4af5 wp-block-paragraph\">[3] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40117876\/\" target=\"_blank\" rel=\"noreferrer noopener\">Extraction, structure, activity and application of konjac glucomannan<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Konjac is a perennial plant whose konjac glucomannan (KGM) has multiple biological properties, including anti-cancer, immunomodulating, and prebiotic effects. KGM is used in food and pharmaceutical products where its biocompatibility and gel properties are central. Research focuses on the extraction and application of KGM to improve treatment for cancer and other diseases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-82b63f6f81bacb91786cdccd9c57d16c wp-block-paragraph\">[4] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39778993\/\" target=\"_blank\" rel=\"noreferrer noopener\">Elucidation of the fine structure and anti-breast tumor activity of a glucomannan from the pseudobulbs of Pleione bulbocodioides<\/a> (PubMed, 2925) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: The polysaccharide PBP, a linear glucomannan isolated from the pseudobulb of <em>Pleione bulbocodioides<\/em>, has shown anti-tumor activity against breast cancer. It consists of mannose and glucose and can stimulate the immune system by increasing CD4+ and CD8+ T cells. This suggests PBP could contribute to cancer treatment, especially against breast cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0de5bdc2e9e268793d032242e29078ff wp-block-paragraph\">[5] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39701258\/\" target=\"_blank\" rel=\"noreferrer noopener\">Modification of a O-acetyl-glucomannan from Dendrobium officinale by selenylation modification and its anti-gastric cancer enhancing activity<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This study isolated the polysaccharide YDOP-1, an O-acetyl-glucomannan from <em>Dendrobium officinale<\/em>, with moderate anti-gastric cancer effects. After selenium modification, YDOP-Se, where selenium is introduced, became significantly more effective at inhibiting cancer cell growth by promoting apoptosis. YDOP-Se has potential for use in cancer treatment, especially against gastric cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-925611db3d9dd3639af24f6a407a9317 wp-block-paragraph\">[6] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40061034\/\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Amorphophallus konjac<\/em>: traditional uses, bioactive potential, and emerging health applications<\/a> (PubMed, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Konjac glucomannan (KGM) from <em>Amorphophallus konjac<\/em> offers health benefits such as weight control, blood sugar stabilization, and improved gut health. It also has anti-inflammatory properties and may help against cancer and autoimmune diseases. Research has improved extraction, though challenges with allergies and purity remain. KGM has great potential in food and medicine.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ac897c854caf33ffda87734e853037c8 wp-block-paragraph\">[7] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39528189\/\" target=\"_blank\" rel=\"noreferrer noopener\">A highly branched glucomannan from the fruiting body of Schizophyllum commune: Structural characteristics and antitumor properties analysis<\/a> (PubMed, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: SCP-1, a branched glucomannan from <em>Schizophyllum commune<\/em>, can inhibit the growth of lung cancer cells by inducing apoptosis. It has a complex structure and shows potential as a cancer agent.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> Jun 26, 2025. Last revised: Apr 28, 2026<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Dietary_Supplements_Grouped_by_Effect\" >Dietary Supplements Grouped by Effect<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Dietary_Supplements_Alphabetical\" >Dietary Supplements Alphabetical<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Glucomannan_and_cancer\" >Glucomannan and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#What_is_glucomannan\" >What is glucomannan<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Mechanisms_of_action\" >Mechanisms of action<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Potential_in_cancer\" >Potential in cancer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Advantages_of_glucomannan\" >Advantages of glucomannan<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Disadvantages_and_limitations\" >Disadvantages and limitations<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Clinical_studies\" >Clinical studies<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Safety\" >Safety<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Dispensing_and_application\" >Dispensing and application<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/jegharkraeft.dk\/en\/glucomannan\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Dietary Supplements Grouped by Effect Dietary Supplements Alphabetical A,. B,. C,. D,. E+F,. G,. H,. I+J+K,. L,. M,. N,. O,. P,. Q,. R,. S,. T,. U+V+Z Glucomannan and cancer Summary of glucomannan Effect: Potential in cancer: Main limitation: Recap: What is glucomannan Glucomannan is a water-soluble dietary fiber extracted from the root of the konjac [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":35070,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[375,374,389],"tags":[],"class_list":["post-35080","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alternative-treatments","category-treatments","category-supplements"],"modified_by":"Hanne","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=35080"}],"version-history":[{"count":6,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35080\/revisions"}],"predecessor-version":[{"id":35938,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/35080\/revisions\/35938"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/35070"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=35080"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=35080"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=35080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}