{"id":33272,"date":"2025-03-27T22:28:05","date_gmt":"2025-03-27T21:28:05","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=33272"},"modified":"2026-04-11T18:48:23","modified_gmt":"2026-04-11T17:48:23","slug":"repurposed-drugs-and-radiotherapy","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/","title":{"rendered":"Repurposed drugs and radiotherapy \u2013 are there interactions"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-59dcf8347175cdaeea61361c9f1241a5 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-85c9ab605a9af581478ba1bfba8fd611\"><span class=\"ez-toc-section\" id=\"Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatments-overview\/\">Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-52532d4beacf4a32227a79286a8276fc\"><span class=\"ez-toc-section\" id=\"Complementary_and_Alternative_Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/alternative-cancer-treatments-overview\/\">Complementary and Alternative Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-668637ae64769eb795ce4acdaace417d has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/jegharkraeft.dk\/akupunktur\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Physical treatments<\/mark><\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-438405c4e63b6142de56511aa7c712e6\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">Repurposed Drugs<\/a><\/mark><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9504e56e950d068c15963cbdbf1fdaaf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b\/\">No medication \u2013 Plan B<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50bb8d7b4bb216418ba3c0d4a402648c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-chemotherapy\/\">Repurposed drugs and chemotherapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-fff4be854f38e5cbc29becc064796ae2\"><a href=\"#repurposed-drugs-and-radiotherapy\">Repurposed drugs and radiotherapy (scroll down)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7098df34ebce445cd1790d85e10991eb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/flcccs-ranking\/\">FLCCC\u2019s ranking of repurposed drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c827eb85783b3d07583409effc04d57\"><a href=\"https:\/\/jegharkraeft.dk\/en\/brain-metastases-and-bloodbrain-barrier\/\">Brain metastases and the blood-brain barrier<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-cf6cfac91ed1b7d193bc5d25a711b818\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bombs-fire-extinguishers-and-timing\/\">Bombs, fire extinguishers, and timing<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1080\" height=\"812\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler.jpg\" alt=\"Repurposed drugs og str\u00e5lebehandling symboliseret ved klipper der ligger omgivet af hav, der sl\u00e5r skummende ind over disse. Havet er azurbl\u00e5t og klart.\" class=\"wp-image-33189\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler.jpg 1080w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler-600x451.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler-300x226.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler-1024x770.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler-768x577.jpg 768w\" sizes=\"auto, (max-width: 1080px) 100vw, 1080px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 class=\"wp-block-heading\" id=\"repurposed-drugs-and-radiotherapy\"><span class=\"ez-toc-section\" id=\"Repurposed_drugs_and_radiotherapy\"><\/span>Repurposed drugs and radiotherapy<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Content:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-fe954b0582545c53a6fb757fbfade889\"><strong><a href=\"#repurposed-drugs-straaler\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#1_Repurposed_drugs_and_radiotherapy_%E2%80%93_how_safe_is_it\">Repurposed drugs and radiotherapy \u2013 how safe is it<\/a> (scroll down)<\/strong><\/li>\n\n\n\n<li><a href=\"#forskel-kemo-straaler-drugs\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#2_Difference_in_suitability_for_radiation_compared_to_chemo\">Difference in suitability for radiation compared to chemo<\/a> (scroll down)<\/li>\n\n\n\n<li><a href=\"#rangering-af-sikkerhed-straaler\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Repurposed_drugs_and_radiotherapy_3_Suitability_ranking\">Suitability ranking<\/a> (scroll down)<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Repurposed_drugs_and_radiotherapy_%E2%80%93_how_safe_is_it\"><\/span>1. Repurposed drugs and radiotherapy &#8211; how safe is it<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In recent years, there has been an increased interest in the use of repurposed drugs. These were originally developed for other purposes, but some have proved interesting in combination with radiotherapy. The goal is to improve treatment outcomes by increasing the sensitivity of cancer cells to radiation (radiosensitization) while simultaneously protecting normal tissue from radiation-induced damage. Below, the potential benefits and risks of combining selected repurposed drugs with radiotherapy are reviewed. However, your physician&#8217;s assessment will always override any information from this site.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Note\"><\/span>Note<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">This overview is largely a result of extensive searches using Gemini AI and DeepSeek. I find it extremely difficult to evaluate the validity of the data, though I generally have positive experiences with the results they present. If you are aware of properties or interactions not mentioned on this page, I hope you will contact me. It is virtually impossible for a single person to keep this information completely updated\u2014despite the best of intentions. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See <a href=\"https:\/\/jegharkraeft.dk\/en\/about-cantact-thanks-mail\/#kontaktinfo\">contact info.<\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"1_Aspirin\"><\/span>1. Aspirin<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Aspirin has anti-inflammatory properties that can potentially reduce radiation-induced inflammation.<\/li>\n\n\n\n<li>Some studies suggest that aspirin may have a radiosensitizing effect, meaning it can make cancer cells more susceptible to radiation.<\/li>\n\n\n\n<li>Aspirin also has blood-thinning properties.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Increased risk of bleeding, which can be problematic, especially with radiotherapy in areas with high bleeding risk.<\/li>\n\n\n\n<li>Can cause gastrointestinal side effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Bleeding risk:<\/strong> Aspirin can increase the risk of bleeding, especially with concurrent use of other blood-thinning medications.<\/li>\n\n\n\n<li><strong>Gastrointestinal side effects:<\/strong> Increased risk of stomach ulcers and other gastrointestinal issues.<\/li>\n\n\n\n<li><strong>Radiosensitization:<\/strong> Can potentially increase the effect of radiotherapy, but further research is needed.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-link-color wp-elements-a31b06b320c7fc43166c1de74aa656de wp-block-paragraph\">[1] <a href=\"https:\/\/www.mdpi.com\/2072-6694\/17\/13\/2157\" target=\"_blank\" rel=\"noopener\">Targeting DAMPs by Aspirin Inhibits Head and Neck Cancer Stem Cells and Stimulates Radio-Sensitization to Proton Therapy<\/a> (MDPI, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A scientific study demonstrating that aspirin functions as a radiosensitizer during proton therapy by eliminating cancer stem cells (CSCs).<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-84ae3eee880be77796e91577c6db7910 wp-block-paragraph\">[2] <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0006291X24013640\" target=\"_blank\" rel=\"noreferrer noopener\">Aspirin enhances radio\/chemo-therapy sensitivity in&nbsp;<em>C. elegans<\/em>&nbsp;by inducing germ cell apoptosis and suppresses RAS overactivated tumorigenesis via mtROS-mediated DNA damage and MAPK pathway<\/a> (Science Direct, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research demonstrating that aspirin increases sensitivity to treatment and suppresses tumor growth through oxidative stress and DNA damage pathways.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7d333fbbe9c096afafd12b57cff5bee5 wp-block-paragraph\">[3] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12897594\/\" target=\"_blank\" rel=\"noreferrer noopener\">The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review<\/a> (PMC, 2026) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A brand new systematic review of aspirin&#8217;s role in suppressing the spread of cancer through both platelet-dependent and tumor-internal mechanisms.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Celecoxib\"><\/span>2. Celecoxib<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Celecoxib is a COX-2 inhibitor with anti-inflammatory and analgesic properties.<\/li>\n\n\n\n<li>Can potentially reduce radiation-induced inflammation and pain.<\/li>\n\n\n\n<li>Some studies suggest that COX-2 inhibitors may have radiosensitizing effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Increased risk of cardiovascular side effects.<\/li>\n\n\n\n<li>Can cause gastrointestinal side effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cardiovascular risks:<\/strong> Increased risk of heart attack and stroke.<\/li>\n\n\n\n<li><strong>Gastrointestinal side effects:<\/strong> Increased risk of ulcers and other gastrointestinal problems.<\/li>\n\n\n\n<li><strong>Radiosensitization:<\/strong> Possible enhanced effect of radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dfbd748c3f92a6f5dba957fa055eee23 wp-block-paragraph\">[4] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12689966\/\" target=\"_blank\" rel=\"noreferrer noopener\">Celecoxib in oncology: targeting the COX-2\/PGE2 axis to reprogram the tumor immune microenvironment and enhance multimodal therapy<\/a> (PMC, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article describing celecoxib&#8217;s ability to reprogram the tumor&#8217;s immune environment and its synergistic effects with both chemotherapy and radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7ab34bdc7520c753325500a17300847e wp-block-paragraph\">[5] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39346725\/\" target=\"_blank\" rel=\"noreferrer noopener\">Association of COX-inhibitors with cancer patients&#8217; survival under chemotherapy and radiotherapy regimens: a real-world data retrospective cohort analysis<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A retrospective analysis of real-world data showing how COX inhibitors affect survival in patients undergoing various treatment regimens.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0722fd4d63b182be76dbad417fc17579 wp-block-paragraph\">[6] <a href=\"https:\/\/www.cabidigitallibrary.org\/doi\/full\/10.5555\/20210257990\" target=\"_blank\" rel=\"noopener\">The efficacy of celecoxib during chemoradiation in locally advanced head and neck carcinoma; a phase 2 randomized placebo control clinical trial. <\/a>(International Journal of Cancer Management, CABI, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A randomized phase 2 study showing that celecoxib improves survival and delays side effects in the mucous membranes during radiotherapy for head and neck cancer.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Desloratadine\"><\/span>3. Desloratadine<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Desloratadine is an antihistamine that can reduce allergic reactions and inflammation, which may benefit patients experiencing skin irritation from radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause drowsiness and fatigue.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Drowsiness and fatigue:<\/strong> May exacerbate fatigue caused by radiotherapy.<\/li>\n\n\n\n<li><strong>Immune system impact:<\/strong> Possible influence on the immune system&#8217;s response to radiation.<\/li>\n\n\n\n<li><strong>Liver metabolism:<\/strong> Both desloratadine and certain radiation treatments are metabolized in the liver.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ca3adf3412df2c302affeee55ff36b2a wp-block-paragraph\">[7] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35117743\/\" target=\"_blank\" rel=\"noreferrer noopener\">Atezolizumab-induced psoriasis in a patient with metastatic lung cancer-a case report<\/a> (PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A case report discussing skin reactions and the use of antihistamines during cancer therapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-88a004c399468d84861be84708a11c56 wp-block-paragraph\">[8] <a href=\"https:\/\/assets.cureus.com\/uploads\/review_article\/pdf\/326618\/20250324-811587-bmr0aq.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">The Impact of Antihistamines on Immunotherapy: A Systematic Review<\/a> (Cureus, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review analyzing how antihistamines interact with cancer treatments and the immune microenvironment<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b72415d5069de15551429e6d207cb940 wp-block-paragraph\">[9] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7238774\/\" target=\"_blank\" rel=\"noreferrer noopener\">Desloratadine, a Novel Antigrowth Reagent for Bladder Cancer<\/a> (PMC, 2020) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study demonstrating for the first time that desloratadine can directly inhibit the growth and spread of bladder cancer cells, making it relevant as a supplementary treatment.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"4_Dipyridamole\"><\/span>4. Dipyridamole<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Dipyridamole has anti-inflammatory and antithrombotic properties.<\/li>\n\n\n\n<li>Can potentially protect normal tissue from radiation-induced damage.<\/li>\n\n\n\n<li>Some studies suggest it may increase blood flow to tumor tissue, potentially improving radiotherapy effectiveness.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause headaches and dizziness.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Increased blood flow:<\/strong> May enhance the delivery of oxygen and treatment to tumor tissue.<\/li>\n\n\n\n<li><strong>Tissue protection:<\/strong> Possible protective effect on normal cells against radiation.<\/li>\n\n\n\n<li><strong>Side effects:<\/strong> Headaches, dizziness, and other systemic side effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-45e5928014e6b53a0b10c76b48834d17 wp-block-paragraph\">[10] <a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2023.1240889\/full\" target=\"_blank\" rel=\"noreferrer noopener\">Nuclear medicine imaging methods of early radiation-induced cardiotoxicity: a ten-year systematic review<\/a> (Frontiers in Oncology, 2023) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review analyzing nuclear imaging techniques to monitor heart damage after radiotherapy. It describes how pharmacologic stress using dipyridamole allows for the early detection of impaired myocardial blood flow and microvascular dysfunction<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ffdef1c0ff37a357a23c5d6898789511 wp-block-paragraph\">[11] <a href=\"https:\/\/dc.rsmu.press\/archive\/2026\/1\/3\/content?lang=en\" target=\"_blank\" rel=\"noreferrer noopener\">Drug Chemistry<\/a> (Drug Chemistry, 2026) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article discussing pharmacological strategies for radiation protection. It notes that pre-radiation administration of dipyridamole improves survival rates and supports hematopoiesis by protecting bone marrow cells from radiation-induced injury.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c8ee9ed4de9d5be7a6acf5e53edb011c wp-block-paragraph\">[12] <a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acsami.3c13855\" target=\"_blank\" rel=\"noreferrer noopener\">Enzyme-Induced Shape-Shifting Peptide Nanocarrier Coloaded with Paclitaxel and Dipyridamole Inhibits Platelet Function and Tumor Metastasis<\/a> (ACS Applied Materials &amp; Interfaces, 2023) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study demonstrating that dipyridamole can inhibit tumor-associated platelets to maintain vascular integrity. This mechanism increases the perfusion of therapeutic agents into solid tumors, helping to overcome the hypoxic conditions that often cause radiotherapy failure.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"5_Disulfiram\"><\/span>5. Disulfiram<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Disulfiram has shown promising results in preclinical studies as a radiosensitizing agent.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause severe side effects, especially with concurrent alcohol consumption.<\/li>\n\n\n\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Radiosensitization:<\/strong> May significantly increase the effectiveness of radiation therapy.<\/li>\n\n\n\n<li><strong>Severe side effects:<\/strong> High risk of toxicity if alcohol is consumed during treatment.<\/li>\n\n\n\n<li><strong>Research status:<\/strong> Clinical safety and effective dosing are still being established.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ea2c91247188a28a5a8254f318d9fb2b wp-block-paragraph\">[13] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12940803\/\" target=\"_blank\" rel=\"noreferrer noopener\">Effects of Disulfiram and Copper in Combination with Temozolomide on Survival in Rat Glioma Model<\/a> (PMC, 2026)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A new study showing how the combination of disulfiram and copper can increase survival and reduce tumor size in brain tumors.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-5d84a5fa30ae668d6fb6aecfc72c555b wp-block-paragraph\">[14] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39307526\/\" target=\"_blank\" rel=\"noreferrer noopener\">Disulfiram Upgrades the Radiosensitivity of Osteosarcoma by Enhancing Apoptosis and P53-Induced Cell Cycle Arrest <\/a>(PubMed, 2019)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research demonstrating that disulfiram makes bone cancer cells more vulnerable to radiation by triggering cell cycle arrest.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1308322c175060c024e08a2f8a64bc22 wp-block-paragraph\">[15] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38768767\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Phase 1\/2 Study of Disulfiram and Copper With Concurrent Radiation Therapy and Temozolomide for Patients With Newly Diagnosed Glioblastoma<\/a> (PubMed, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A phase 1\/2 trial evaluating the safety and efficacy of combining disulfiram with standard radiation and chemo for brain tumors.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"6_Doxycycline\"><\/span>6. Doxycycline<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Doxycycline has anti-inflammatory and antiproliferative properties.<\/li>\n\n\n\n<li>Some studies suggest it may protect normal tissue from radiation-induced damage.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause gastrointestinal side effects and photosensitivity.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Tissue protection:<\/strong> Possible protective effect against radiation damage in healthy cells.<\/li>\n\n\n\n<li><strong>Gastrointestinal side effects:<\/strong> Risk of nausea, vomiting, and diarrhea.<\/li>\n\n\n\n<li><strong>Photosensitivity:<\/strong> Increased sensitivity to sunlight.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc5023c6905ff949d4cc4b4009f2699a wp-block-paragraph\">[16] <a href=\"https:\/\/www.mdpi.com\/2079-6382\/11\/3\/331\" target=\"_blank\" rel=\"noreferrer noopener\">The Interplay among Radiation Therapy, Antibiotics and the Microbiota: Impact on Cancer Treatment Outcomes<\/a> (MDPI, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A review article discussing how antibiotics like doxycycline affect the microbiome and treatment outcomes in radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-292d265eded8307162e1bb7c5822f7d9 wp-block-paragraph\">[17] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39270987\/\" target=\"_blank\" rel=\"noreferrer noopener\">Enhanced radiosensitivity of pancreatic cancer achieved through inhibition of Cyclin-dependent kinase 1<\/a> (PubMed, 2019)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study exploring mechanisms that can be targeted by agents like doxycycline to improve radiation response in pancreatic cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-588e410fb4a1a2187eddc65437b86f0d wp-block-paragraph\">[18] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34973952\/\" target=\"_blank\" rel=\"noreferrer noopener\">A Brief look at antitumor effects of doxycycline in the treatment of colorectal cancer and combination therapies<\/a> (PubMed, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A review of doxycycline&#8217;s antitumor mechanisms in colorectal cancer. It describes how the drug inhibits tumor growth and potentially enhances chemo- and immunotherapy.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"7_Fenbendazole\"><\/span>7. Fenbendazole<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fenbendazole has shown promising results in preclinical studies as an antitumor agent.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n\n\n\n<li>Limited documentation regarding its use in combination with radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antitumor effect:<\/strong> Potential direct action against cancer cell survival.<\/li>\n\n\n\n<li><strong>Research status:<\/strong> Clinical safety and human dosages are not yet established.<\/li>\n\n\n\n<li><strong>Limited evidence:<\/strong> Very few studies exist regarding its interaction with radiation.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1ddef7b36c56641270e2473ac8b70808 wp-block-paragraph\">[19] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40509264\/\" target=\"_blank\" rel=\"noopener\">Fenbendazole Exhibits Antitumor Activity Against Cervical Cancer Through Dual Targeting of Cancer Cells and Cancer Stem Cells: Evidence from In Vitro and In Vivo Models<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study exploring how fenbendazole targets resistant cancer stem cells by disrupting microtubule dynamics and arresting the cell cycle. This mechanism is critical for sensitizing aggressive tumors that are typically resistant to standard radiation and chemotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-310d2b2e8353af76ea684dc7596c27be wp-block-paragraph\">[20] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39477286\/\" target=\"_blank\" rel=\"noreferrer noopener\">Fenbendazole and Diisopropylamine Dichloroacetate Exert Synergistic Anti-cancer Effects by Inducing Apoptosis and Arresting the Cell Cycle in A549 Lung Cancer Cells<\/a> (PubMed, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research showing synergistic effects of fenbendazole in lung cancer cells, though radiation was not the primary focus.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-9d4508c7ce41874a5bd90ea907de95fe wp-block-paragraph\">[20] <a href=\"https:\/\/cancerchoices.org\/therapy\/mebendazole-or-fenbendazole\/safety\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mebendazole or Fenbendazole: Safety and precautions<\/a> (CancerChoices, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A clinical review of benzimidazoles in oncology, highlighting their emerging role in combination with radiation. It discusses the current state of evidence and provides context for using these agents in multimodal treatment plans.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"8_Ivermectin\"><\/span>8. Ivermectin<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ivermectin has shown promising results in preclinical studies as an antitumor and radiosensitizing agent.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antitumor effect:<\/strong> May inhibit several signaling pathways critical for cancer growth.<\/li>\n\n\n\n<li><strong>Radiosensitization:<\/strong> Potentially increases the efficacy of radiotherapy.<\/li>\n\n\n\n<li><strong>Research status:<\/strong> More clinical evidence is needed to confirm benefits in humans.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d3475c3b44ef73587f38460b767c4e42 wp-block-paragraph\">[22] <a href=\"https:\/\/www.researchsquare.com\/article\/rs-2921176\/v1\" target=\"_blank\" rel=\"noreferrer noopener\">Ivermectin modulates lung toxicity induced by \u03b3-radiation viaTLR4\/ NF-\u03ba\u03b2 \/MAPK pathways<\/a> (Research Square, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study investigating how ivermectin can reduce radiation-induced lung damage by modulating inflammatory pathways.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-aa50cf8b5011fd74e5b7d50ce57c782c wp-block-paragraph\">[23] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35610277\/\" target=\"_blank\" rel=\"noreferrer noopener\">Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation<\/a> (PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research discussing mechanisms of radiation damage where agents like ivermectin might play a modulatory role.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-f7b45e83ad55cd45a56129caa6a708bb wp-block-paragraph\">[24] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12817848\/\" target=\"_blank\" rel=\"noreferrer noopener\">Synergistic potential of Ivermectin and doxorubicin in oral squamous cell carcinoma: an in vitro investigation<\/a> (PMC, 2026) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study showing that ivermectin works synergistically with conventional treatment by increasing oxidative stress and inducing cell death in oral cancer.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"9_LDN_low-dose_naltrexone\"><\/span>9. LDN (low-dose naltrexone)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>LDN can modulate the immune system and reduce inflammation, which may be beneficial for patients experiencing radiotherapy side effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause sleep disturbances and other minor side effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Immunomodulation:<\/strong> Potentially beneficial effect on the body&#8217;s immune response.<\/li>\n\n\n\n<li><strong>Inflammation reduction:<\/strong> May reduce the systemic and local inflammation caused by radiation.<\/li>\n\n\n\n<li><strong>Side effects:<\/strong> Sleep disturbances and vivid dreams are common.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4009f1e28cd0754c5a7da4a274ab7879 wp-block-paragraph\">[25] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32787083\/\" target=\"_blank\" rel=\"noreferrer noopener\">Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma<\/a> (PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study describing new drug discovery efforts for brain tumors where immune-modulating agents are often considered part of the broader strategy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-95d40d4ba25dfc4614cb1057d93ac4f0 wp-block-paragraph\">[26] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10968813\/\" target=\"_blank\" rel=\"noreferrer noopener\">Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy<\/a> (PMC, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review summarizing the evidence for LDN as a supplement that can reduce tumor size and improve quality of life during treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1d556ffa7c46deaebce13dc0489c6345 wp-block-paragraph\">[27] <a href=\"https:\/\/www.mdpi.com\/2072-6694\/16\/6\/1240\" target=\"_blank\" rel=\"noreferrer noopener\">Low-Dose Naltrexone as an Adjuvant in Combined Anticancer Therapy<\/a> (MDPI, 2018)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A review of the potential for LDN to serve as a supporting agent in various cancer treatment protocols.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"10_Melatonin\"><\/span>10. Melatonin<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Melatonin has antioxidant and anti-inflammatory properties.<\/li>\n\n\n\n<li>Can potentially protect normal tissue from radiation-induced damage.<\/li>\n\n\n\n<li>Some studies suggest it may have a radiosensitizing effect on tumor cells.<\/li>\n\n\n\n<li>Helps with sleep disturbances often associated with cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause drowsiness and changes in sleep patterns.<\/li>\n\n\n\n<li>There are some conflicting results regarding melatonin and specific cancer treatments.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Tissue protection:<\/strong> May serve as a radioprotector for healthy cells.<\/li>\n\n\n\n<li><strong>Radiosensitization:<\/strong> Potentially enhances the destruction of cancer cells.<\/li>\n\n\n\n<li><strong>Sleep patterns:<\/strong> May cause drowsiness or shift the circadian rhythm.<\/li>\n\n\n\n<li><strong>Hormonal influence:<\/strong> Must be considered in hormone-sensitive cancers due to its biological activity.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c874c1aaaca6cef3ee9a112cacd568c7 wp-block-paragraph\">[28] <a href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/09553002.2018.1446227\" target=\"_blank\" rel=\"noreferrer noopener\">Therapeutic potential of melatonin for breast cancer radiation therapy patients<\/a> (Taylor &amp; Francis, 2017)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study discussing how melatonin can improve outcomes and reduce side effects in breast cancer patients undergoing radiation.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0f9bd3233c03f3ad1c4c81317a464221 wp-block-paragraph\">[29] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33110479\/\" target=\"_blank\" rel=\"noreferrer noopener\">Melatonin increases overall survival of prostate cancer patients with poor prognosis after combined hormone radiation treatment<\/a> (PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research showing improved survival in prostate cancer patients when melatonin was added to a combined treatment regimen.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b445d8ccb18e0870f1fe3a1d5f571465 wp-block-paragraph\">[30] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34837684\/\" target=\"_blank\" rel=\"noreferrer noopener\">Radioprotective Effects of Combined Melatonin and Famotidine Treatment on Radiation Induced Apoptosis in Peripheral Blood Leukocytes of Breast Cancer Patients and Normal Individuals <\/a>(PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research documenting that melatonin can help protect blood cells from the damaging effects of radiation.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"11_Metformin\"><\/span>11. Metformin<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Metformin has shown promising results in preclinical studies as an antitumor and radiosensitizing agent.<\/li>\n\n\n\n<li>Can potentially reduce radiation-induced inflammation.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause gastrointestinal side effects.<\/li>\n\n\n\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antitumor effect:<\/strong> Targets metabolic pathways in cancer cells.<\/li>\n\n\n\n<li><strong>Radiosensitization:<\/strong> May increase the susceptibility of tumors to radiation.<\/li>\n\n\n\n<li><strong>Gastrointestinal side effects:<\/strong> Common risk of nausea and diarrhea.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dff1330bd2d82419ab436e67f992eb71 wp-block-paragraph\">[31] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11871473\/\" target=\"_blank\" rel=\"noreferrer noopener\">Evaluation of the effect of metformin as a radiosensitiser in solid tumours: A systematic review<\/a> (PMC, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review evaluating metformin&#8217;s ability to make solid tumors more sensitive to radiotherapy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-a34f41b1c7b89fe81ee4af66c4c02743 wp-block-paragraph\">[31A] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40028423\/\" target=\"_blank\" rel=\"noreferrer noopener\">Evaluation of the effect of metformin as a radiosensitiser in solid tumours: A systematic review<\/a> (PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review analyzing the evidence for metformin as a radiosensitizer across various types of solid tumors.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-19e05618104a7cf40a73781ccddc5dad wp-block-paragraph\">[32] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12472684\/\" target=\"_blank\" rel=\"noreferrer noopener\">Survival and Radiotherapy-Related Adverse Events in Patients Receiving Radiotherapy and Concurrent Metformin<\/a> (PMC, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A meta-analysis investigating metformin&#8217;s impact on survival and side effects (including heart protection) in patients undergoing radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-381a12099386ad9497dc33217dd0e632 wp-block-paragraph\">[33] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40108865\/\" target=\"_blank\" rel=\"noreferrer noopener\">Preventive Effect of Metformin in Radiation-Induced Xerostomia<\/a> (PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research investigating whether metformin can prevent dry mouth caused by radiation to the head and neck.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"12_NSAIDs_Non-steroidal_anti-inflammatory_drugs\"><\/span>12. NSAIDs (Non-steroidal anti-inflammatory drugs)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>NSAIDs have anti-inflammatory and analgesic properties.<\/li>\n\n\n\n<li>Can potentially reduce radiation-induced inflammation and pain.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Increased risk of gastrointestinal and cardiovascular side effects.<\/li>\n\n\n\n<li>Can increase the risk of bleeding.<\/li>\n\n\n\n<li>May decrease kidney function.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Gastrointestinal side effects:<\/strong> High risk of ulcers and bleeding.<\/li>\n\n\n\n<li><strong>Cardiovascular risks:<\/strong> Increased risk of heart attack and stroke with certain NSAIDs.<\/li>\n\n\n\n<li><strong>Bleeding risk:<\/strong> Systemic impact on platelet function.<\/li>\n\n\n\n<li><strong>Renal function:<\/strong> Possible impairment of kidney health.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c9bc69794a5a4baa888c79a9c91a52fd wp-block-paragraph\">[34] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36545311\/\" target=\"_blank\" rel=\"noopener\">Targeting cancer-related inflammation with non-steroidal anti-inflammatory drugs: Perspectives in pharmacogenomics<\/a> (PubMed, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article reviewing the latest advances in using NSAIDs to improve the efficacy of existing cancer treatments by controlling inflammation.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dfce7fde28f7891e1551c3ac8239ecd8 wp-block-paragraph\">[35] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39304400\/\" target=\"_blank\" rel=\"noreferrer noopener\">Combination of radiotherapy and immunotherapy in duality with the protumoral action of radiation<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article discussing how anti-inflammatory drugs can be used to modulate the immune environment and improve the results of combined radiotherapy and immunotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0fd6ee8377369e1217c505529b5e0964 wp-block-paragraph\">[36] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38229111\/\" target=\"_blank\" rel=\"noreferrer noopener\">The radiation- and chemo-sensitizing capacity of diclofenac can be predicted by a decreased lactate metabolism and stress response<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research exploring the metabolic mechanisms by which diclofenac sensitizes tumors to treatment.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"13_Plaquenil_Hydroxychloroquin\"><\/span>13. Plaquenil (Hydroxychloroquin)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Plaquenil has anti-inflammatory and immunomodulating properties.<\/li>\n\n\n\n<li>Some studies suggest it may have a radiosensitizing effect by inhibiting autophagy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause visual disturbances and other side effects.<\/li>\n\n\n\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Radiosensitization:<\/strong> May block the survival mechanism cancer cells use to resist radiation.<\/li>\n\n\n\n<li><strong>Visual disturbances:<\/strong> Risk of retinal damage with long-term use.<\/li>\n\n\n\n<li><strong>Immune modulation:<\/strong> Possible influence on the inflammatory environment around the tumor.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7005048d04a4e9a0c90f69a585fa6f00 wp-block-paragraph\">[37] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12541592\/\" target=\"_blank\" rel=\"noreferrer noopener\">Hydroxychloroquine&#8217;s diverse targets: a new frontier in precision medicine<\/a> (PMC, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A systematic review of hydroxychloroquine&#8217;s mechanisms, including its role in blocking cancer cell survival strategies (autophagy).<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-73ad0bdc96e15e7795640ff75781c696 wp-block-paragraph\">[38] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39000565\/\" target=\"_blank\" rel=\"noreferrer noopener\">Blockage of Autophagy for Cancer Therapy: A Comprehensive Review<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A comprehensive review of how blocking the cell&#8217;s &#8220;self-cleaning&#8221; process (autophagy) can make cancer cells more susceptible to treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-cf610f048f6d3e20943b706fd6820290 wp-block-paragraph\">[39] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37463410\/\" target=\"_blank\" rel=\"noreferrer noopener\">Autophagy Inhibition Increased Sensitivity of Pancreatic Cancer Cells to Carbon Ion Radiotherapy<\/a> (PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research showing that blocking autophagy increases the effectiveness of specialized radiation therapy.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"14_Propranolol\"><\/span>14. Propranolol<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Propranolol has shown promising results in preclinical studies as an antitumor agent.<\/li>\n\n\n\n<li>Can potentially reduce radiation-induced inflammation.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause bradycardia (slow heart rate) and other cardiovascular side effects.<\/li>\n\n\n\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antitumor effect:<\/strong> May interfere with stress-induced tumor growth pathways.<\/li>\n\n\n\n<li><strong>Inflammation reduction:<\/strong> Potential to dampen the body&#8217;s inflammatory response to treatment.<\/li>\n\n\n\n<li><strong>Cardiovascular side effects:<\/strong> Risk of low heart rate and blood pressure.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-687b14c35fef375893a3c4f98ce0e9c0 wp-block-paragraph\">[40] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36831618\/\" target=\"_blank\" rel=\"noreferrer noopener\">Beta Blockers with Statins May Decrease All-Cause Mortality in Patients with Cardiovascular Diseases and Locally Advanced Unresectable Non-Small-Cell Lung Cancer after Chemoradiotherapy<\/a> (Cancers, 2023) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A retrospective cohort study (non-randomized) analyzing 196 patients. The results show that the use of beta-blockers is associated with a significant reduction in all-cause mortality and improved overall survival in patients receiving radical radiotherapy for lung cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-132e744d2cafa290579a28a424101dcc wp-block-paragraph\">[41] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37800663\/\" target=\"_blank\" rel=\"noreferrer noopener\">Intensity-modulated radiotherapy and chemotherapy for canine right atrial tumors: A retrospective study of seven dogs <\/a>(PubMed, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study illustrating how specialized radiotherapy and supportive medications are used to manage aggressive tumors.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-6c6665f6a1337b5dc08dcd20aff005f4 wp-block-paragraph\">[42] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35799748\/\" target=\"_blank\" rel=\"noreferrer noopener\">Clinical value of propranolol combined with oxaliplatin and tigio in concurrent chemoradiotherapy for locally advanced gastric cancer<\/a> (PubMed, 2019)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study evaluating the clinical benefits of adding propranolol to standard treatment for gastric cancer.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"15_Statins\"><\/span>15. Statins<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Statins have shown promising results in preclinical studies as antitumor and radiosensitizing agents.<\/li>\n\n\n\n<li>Can potentially reduce radiation-induced inflammation.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Can cause muscle pain and other side effects.<\/li>\n\n\n\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antitumor effect:<\/strong> Interferes with cholesterol pathways necessary for cancer cell growth.<\/li>\n\n\n\n<li><strong>Radiosensitization:<\/strong> May improve the response rate of tumors to radiation.<\/li>\n\n\n\n<li><strong>Muscle pain:<\/strong> Risk of myalgia or, in rare cases, more severe muscle damage.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1a09ac50a851e9d5ca5e5dd63bdb885a wp-block-paragraph\">[43] <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12570484\/\" target=\"_blank\" rel=\"noreferrer noopener\">Impact of statin use on survival and adverse events in patients with cancer receiving radiotherapy: a systematic review and meta-analysis<\/a> (PMC, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A comprehensive meta-analysis of 21 studies showing improved survival in several cancer types when statins are used alongside radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dcde8adebdf3af8b530190ed7483da57 wp-block-paragraph\">[44] <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1278321822001354\" target=\"_blank\" rel=\"noreferrer noopener\">Interactions of radiation therapy with common and innovative systemic treatments: Antidiabetic treatments, antihypertensives, lipid-lowering medications, immunosuppressive medications and other radiosensitizing methods<\/a> (Science Direct, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article reviewing how common medications like statins interact with radiation and can potentially enhance its effect.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-80cfb07aa021393bda58c5cf45b3de71 wp-block-paragraph\">[45] <a href=\"https:\/\/doi.org\/10.3390\/jcm15020568\" target=\"_blank\" rel=\"noreferrer noopener\">Combining Statins with Radiotherapy for Prostate Cancer: From Photon Experience to Proton Potential<\/a> (Journal of Clinical Medicine, 2026) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A narrative review investigating the role of statins as radiosensitizers in cancer treatment. The article documents that statin use is associated with improved biochemical recurrence-free survival and reduced toxicity in patients undergoing radiotherapy for prostate cancer and other solid tumors.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"16_Vermox_Mebendazole\"><\/span>16. Vermox\/ Mebendazole<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Benefits<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mebendazole has shown promising results in preclinical studies as an antitumor agent.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Requires further research to establish safety and efficacy in clinical practice.<\/li>\n\n\n\n<li>Limited documentation regarding its use in combination with radiotherapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Specific interactions and risks<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Antitumor effect:<\/strong> May inhibit microtubule formation in cancer cells.<\/li>\n\n\n\n<li><strong>Research status:<\/strong> More trials are needed to define its role in a clinical setting.<\/li>\n\n\n\n<li><strong>Limited evidence:<\/strong> Sparse data specifically regarding its interaction with radiation therapy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Scientific support:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-aa83d7e6555024ac531d54998c8d5b2e wp-block-paragraph\">[46] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36555137\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mebendazole Increases Anticancer Activity of Radiotherapy in Radiotherapy-Resistant Triple-Negative Breast Cancer Cells<\/a> (PubMed, 2022) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A study showing that mebendazole significantly increases the effect of radiotherapy, even in otherwise radiation-resistant breast cancer cells, by promoting immune system attacks.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-cc8dccc3ac6792345e41cb107fad1db9 wp-block-paragraph\">[47] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34500557\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anticancer Effect of Benzimidazole Derivatives, Especially Mebendazole, on Triple-Negative Breast Cancer (TNBC) and Radiotherapy-Resistant TNBC In Vivo and In Vitro<\/a> (PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research showing that mebendazole can overcome resistance to radiation in triple-negative breast cancer by inducing DNA damage.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0d0844a1189cd4374564fefd85213778 wp-block-paragraph\">[48] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30414098\/\" target=\"_blank\" rel=\"noreferrer noopener\">Mebendazole and radiation in combination increase survival through anticancer mechanisms in an intracranial rodent model of malignant meningioma<\/a> (PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: Research in an animal model showing increased survival when mebendazole is combined with radiotherapy for brain tumors.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The use of repurposed drugs in combination with radiotherapy represents a promising area of cancer research. However, it must be noted that further research is necessary to firmly establish safety and efficacy. If you are considering using repurposed drugs in connection with radiotherapy, you should always consult your qualified healthcare provider to discuss potential benefits and risks.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/holistiske-laeger-1\/\">Holistic doctors in DK<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>To be continued\u2026<\/strong><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> 28.03.25. Last updated April 8, 2026<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-720711dc\">\n<h2 class=\"wp-block-heading\" id=\"forskel-kemo-straaler-drugs\"><span class=\"ez-toc-section\" id=\"Repurposed_drugs_and_radiotherapy_2_Difference_between_chemo_and_radiation\"><\/span>Repurposed drugs and radiotherapy<br>2. Difference between chemo and radiation<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Content:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-sort-tekst-color has-text-color\"><strong><a href=\"#repurposed-drugs-straaler\"><\/a><\/strong><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#1_Repurposed_drugs_and_radiotherapy_%E2%80%93_how_safe_is_it\">Repurposed drugs and radiotherapy \u2013 how safe is it<\/a> (scroll down)<\/li>\n\n\n\n<li class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c48936e8605194630f6f253447dcb47a\"><a href=\"#forskel-kemo-straaler-drugs\"><\/a><strong><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#2_Difference_in_suitability_for_radiation_compared_to_chemo\">Difference in suitability for radiation compared to chemo<\/a> (scroll down)<\/strong><\/li>\n\n\n\n<li><a href=\"#rangering-af-sikkerhed-straaler\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Repurposed_drugs_and_radiotherapy_3_Suitability_ranking\">Suitability ranking<\/a> (scroll down)<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"2_Difference_in_suitability_for_radiation_compared_to_chemo\"><\/span>2. Difference in suitability for radiation compared to chemo<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">It is an important nuance to understand that the assessment of repurposed drugs in combination with radiotherapy versus chemotherapy is not necessarily about one combination being &#8220;more positive&#8221; than the other in a general sense. Rather, it is about the potential interactions and mechanisms being different, and that in certain cases, there may be a stronger scientific rationale for investigating the use of repurposed drugs alongside radiotherapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Here are some key points to help understand the difference:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mechanisms\"><\/span>Mechanisms<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Radiotherapy<\/strong> \n<ul class=\"wp-block-list\">\n<li>works by directly damaging the DNA of cancer cells. Repurposed drugs that can increase this damage (radiosensitization) or protect healthy tissue can potentially improve outcomes.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Chemotherapy<\/strong> \n<ul class=\"wp-block-list\">\n<li>works by affecting cell division and growth. Interactions with repurposed drugs can be more complex and potentially increase the risk of unforeseen side effects.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Research\"><\/span>Research<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<ul class=\"wp-block-list\">\n<li>There is a growing body of preclinical and clinical research investigating the use of certain repurposed drugs (e.g., metformin, statins) as radiosensitizers.<\/li>\n\n\n\n<li>Research on repurposed drugs in combination with chemotherapy is more varied, with a greater focus on avoiding negative interactions.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects\"><\/span>Side effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Radiotherapy often has well-defined local side effects that can potentially be modulated by certain repurposed drugs.<\/li>\n\n\n\n<li>Chemotherapy often has systemic side effects, and interactions with repurposed drugs can potentially exacerbate these.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Note-2\"><\/span>Note<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Each cancer patient is unique, and treatment decisions should always be made in consultation with an oncologist. Research into repurposed drugs is still evolving, and more clinical trials are needed to establish their safety and efficacy.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion-2\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The assessment of repurposed drugs in relation to radiotherapy and chemotherapy is complex and depends on various mechanisms and interactions. Radiotherapy has a direct effect on cancer cell DNA, and certain repurposed drugs can enhance this effect or protect healthy tissue. Chemotherapy affects cell division and can have more complex interactions with repurposed drugs, potentially leading to unforeseen side effects.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is an increasing body of research supporting the use of repurposed drugs as radiosensitizers, while studies on their use with chemotherapy are more varied and focus on avoiding negative interactions. Side effects of radiotherapy are often local, while chemotherapy can cause systemic side effects that may be exacerbated by repurposed drugs.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Research in this area is still evolving, and more clinical trials are needed to determine the safety and efficacy of these combinations.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/holistiske-laeger-1\/\">Holistic doctors in DK<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>To be continued\u2026<\/strong><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> 28.03.25<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/03\/Repurposed-drugs-og-straaler.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-c796c35b\">\n<h2 class=\"wp-block-heading\" id=\"rangering-af-sikkerhed-straaler\"><span class=\"ez-toc-section\" id=\"Repurposed_drugs_and_radiotherapy_3_Suitability_ranking\"><\/span>Repurposed drugs and radiotherapy<br>3. Suitability ranking<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Content:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><strong><a href=\"#repurposed-drugs-straaler\"><\/a><\/strong><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#1_Repurposed_drugs_and_radiotherapy_%E2%80%93_how_safe_is_it\">Repurposed drugs and radiotherapy \u2013 how safe is it<\/a> (scroll down)<\/li>\n\n\n\n<li><a href=\"#forskel-kemo-straaler-drugs\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#2_Difference_in_suitability_for_radiation_compared_to_chemo\">Difference in suitability for radiation compared to chemo<\/a> (scroll down)<\/li>\n\n\n\n<li class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-fe3688221699a87ebc5c71f59aaf1820\"><a href=\"#rangering-af-sikkerhed-straaler\"><\/a><strong><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Repurposed_drugs_and_radiotherapy_3_Suitability_ranking\">Suitability ranking<\/a> (scroll down)<\/strong><\/li>\n<\/ol>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"3_Ranking_of_repurposed_drugs_safety_during_radiation\"><\/span>3. Ranking of repurposed drugs safety during radiation<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Rangering af de n\u00e6vnte repurposed drugs i de \u00f8nskede kategorier, baseret p\u00e5 den tilg\u00e6ngelige videnskabelige evidens og potentielle risici:<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Beneficial_in_combination_with_radiotherapy\"><\/span>Beneficial in combination with radiotherapy<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Metformin:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Shows promising results as a radiosensitizer and antitumor agent. Can potentially reduce radiation-induced inflammation.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Melatonin:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Possesses antioxidant and anti-inflammatory properties. Can potentially protect normal tissue and have a radiosensitizing effect.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Statins:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Show promising results as an antitumor agent and radiosensitizer. Can potentially reduce radiation-induced inflammation.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Normally_safe_in_combination_with_radiotherapy\"><\/span>Normally safe in combination with radiotherapy<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Desloratadine:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Can reduce allergic reactions and inflammation. Generally few serious interactions.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Doxycycline:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Possesses anti-inflammatory properties. Can potentially protect normal tissue.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>LDN (Low-Dose Naltrexone):<\/strong> \n<ul class=\"wp-block-list\">\n<li>Can modulate the immune system and reduce inflammation.<\/li>\n\n\n\n<li><strong>Propranolol:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Can potentially reduce radiation-induced inflammation.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Can_be_problematic\"><\/span>Can be problematic<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Aspirin:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Increased risk of bleeding. Can cause gastrointestinal side effects.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Celecoxib:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Increased risk of cardiovascular side effects. <\/li>\n\n\n\n<li>Can cause gastrointestinal side effects.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Dipyridamole:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Can cause headaches and dizziness.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>NSAIDs (Non-steroidal anti-inflammatory drugs):<\/strong> \n<ul class=\"wp-block-list\">\n<li>Increased risk of gastrointestinal and cardiovascular side effects. <\/li>\n\n\n\n<li>Can increase bleeding risk.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Plaquenil (Hydroxychloroquine):<\/strong> \n<ul class=\"wp-block-list\">\n<li>Can cause visual disturbances.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Not_recommended\"><\/span>Not recommended<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Disulfiram:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Can cause serious side effects, especially with simultaneous alcohol consumption. <\/li>\n\n\n\n<li>Requires further research.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Fenbendazole:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Requires further research. L<\/li>\n\n\n\n<li>imited documentation.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Ivermectin:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Requires further research.<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Mebendazole:<\/strong> \n<ul class=\"wp-block-list\">\n<li>Requires further research. <\/li>\n\n\n\n<li>Limited documentation.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Important_note\"><\/span>Important note<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">One should always consult their healthcare provider before taking repurposed drugs in connection with radiotherapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/holistiske-laeger-1\/\">Holistic doctors in DK<\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> 28.03.25<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Treatments\" >Treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Complementary_and_Alternative_Treatments\" >Complementary and Alternative Treatments<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Repurposed_drugs_and_radiotherapy\" >Repurposed drugs and radiotherapy<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#1_Repurposed_drugs_and_radiotherapy_%E2%80%93_how_safe_is_it\" >1. Repurposed drugs and radiotherapy &#8211; how safe is it<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Note\" >Note<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#1_Aspirin\" >1. Aspirin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#2_Celecoxib\" >2. Celecoxib<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#3_Desloratadine\" >3. Desloratadine<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#4_Dipyridamole\" >4. Dipyridamole<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#5_Disulfiram\" >5. Disulfiram<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#6_Doxycycline\" >6. Doxycycline<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#7_Fenbendazole\" >7. Fenbendazole<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#8_Ivermectin\" >8. Ivermectin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#9_LDN_low-dose_naltrexone\" >9. LDN (low-dose naltrexone)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#10_Melatonin\" >10. Melatonin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#11_Metformin\" >11. Metformin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#12_NSAIDs_Non-steroidal_anti-inflammatory_drugs\" >12. NSAIDs (Non-steroidal anti-inflammatory drugs)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#13_Plaquenil_Hydroxychloroquin\" >13. Plaquenil (Hydroxychloroquin)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#14_Propranolol\" >14. Propranolol<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#15_Statins\" >15. Statins<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#16_Vermox_Mebendazole\" >16. Vermox\/ Mebendazole<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Conclusion\" >Conclusion<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Repurposed_drugs_and_radiotherapy_2_Difference_between_chemo_and_radiation\" >Repurposed drugs and radiotherapy 2. Difference between chemo and radiation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#2_Difference_in_suitability_for_radiation_compared_to_chemo\" >2. Difference in suitability for radiation compared to chemo<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Mechanisms\" >Mechanisms<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Research\" >Research<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Side_effects\" >Side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Note-2\" >Note<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Conclusion-2\" >Conclusion<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Repurposed_drugs_and_radiotherapy_3_Suitability_ranking\" >Repurposed drugs and radiotherapy 3. Suitability ranking<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#3_Ranking_of_repurposed_drugs_safety_during_radiation\" >3. Ranking of repurposed drugs safety during radiation<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Beneficial_in_combination_with_radiotherapy\" >Beneficial in combination with radiotherapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Normally_safe_in_combination_with_radiotherapy\" >Normally safe in combination with radiotherapy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Can_be_problematic\" >Can be problematic<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Not_recommended\" >Not recommended<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/#Important_note\" >Important note<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatments Complementary and Alternative Treatments Repurposed drugs and radiotherapy Content: 1. Repurposed drugs and radiotherapy &#8211; how safe is it In recent years, there has been an increased interest in the use of repurposed drugs. These were originally developed for other purposes, but some have proved interesting in combination with radiotherapy. The goal is to [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":33189,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[375,393],"tags":[],"class_list":["post-33272","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-alternative-treatments","category-repurposed-drugs"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=33272"}],"version-history":[{"count":1,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33272\/revisions"}],"predecessor-version":[{"id":33814,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33272\/revisions\/33814"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/33189"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=33272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=33272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=33272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}