{"id":33143,"date":"2025-03-21T19:27:36","date_gmt":"2025-03-21T18:27:36","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=33143"},"modified":"2026-04-11T18:48:48","modified_gmt":"2026-04-11T17:48:48","slug":"disulfiram","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/disulfiram\/","title":{"rendered":"Disulfiram (Antabuse) against cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-aa4749078e0f213c71e7958a670436f1 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-85c9ab605a9af581478ba1bfba8fd611\"><span class=\"ez-toc-section\" id=\"Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatments-overview\/\">Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-52532d4beacf4a32227a79286a8276fc\"><span class=\"ez-toc-section\" id=\"Complementary_and_Alternative_Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/alternative-cancer-treatments-overview\/\">Complementary and Alternative Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-33cf148baf4c28e5b1dcd61f18b97dd1 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7ad2f47b85c34f1c08021b0926de1223\"><a href=\"https:\/\/jegharkraeft.dk\/en\/akupunktur\/\">Physical treatments<\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7b30cba0c9c70debf9b8364d2e856fbe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Repurposed Drugs &#8211; General<\/mark><\/a>\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-780fac237d6d09f0087842050420bfba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/aspirin\/\">Painkillers and anti-inflammatory drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-fad7d0169f73487a5cb08247fb6344df\"><a href=\"https:\/\/jegharkraeft.dk\/en\/dipyridamole\/\">Heart and circulatory medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-110ab3157ece675d1aeb7921af0e506a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\">Antibiotics and antiparasitic agents<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a99575c8ffb4e827783ab6d56f16ed45\"><a href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/\">Diabetes medication<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6c31e64b006d888e2e94cb9770a3c32c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/low-dose-naltrexone\/\">Agents affecting hormones and signaling substances<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-16fbce0801dbf067a450ae03fbe6e372\"><a href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Other medications<\/mark><\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-cd2f64d661161f8f295c3e3d10cedd59\"><a href=\"#disulfiram\">Disulfiram (scroll down)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/desloratadine\/\">Desloratadine, Mildin<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/methylene-blue\/\">Methylene blue<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-66a0e4204f5201bcc8494f5822b38efe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/the-coc-protocol\/\">COC Protocol<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9504e56e950d068c15963cbdbf1fdaaf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b\/\">No medication \u2013 Plan B<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50bb8d7b4bb216418ba3c0d4a402648c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-chemotherapy\/\">Repurposed drugs and chemotherapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-af88e7f595afd58f141d2c174a141555\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/\">Repurposed drugs and radiation therapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7098df34ebce445cd1790d85e10991eb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/flcccs-ranking\/\">FLCCC\u2019s ranking of repurposed drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c827eb85783b3d07583409effc04d57\"><a href=\"https:\/\/jegharkraeft.dk\/en\/brain-metastases-and-bloodbrain-barrier\/\">Brain metastases and the blood-brain barrier<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-cf6cfac91ed1b7d193bc5d25a711b818\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bombs-fire-extinguishers-and-timing\/\">Bombs, fire extinguishers, and timing<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"532\" height=\"1000\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bDisulfiram.jpg\" alt=\"Disulfiram i hvid plastb\u00f8tte - n\u00e6rbillede af etiket. 250 mg tabletter.\" class=\"wp-image-33142\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bDisulfiram.jpg 532w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bDisulfiram-160x300.jpg 160w\" sizes=\"auto, (max-width: 532px) 100vw, 532px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;http:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bDisulfiram.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 class=\"wp-block-heading\" id=\"disulfiram\"><span class=\"ez-toc-section\" id=\"Disulfiram_Antabuse_against_cancer\"><\/span>Disulfiram (Antabuse) against cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h4 class=\"wp-block-heading\">What is disulfiram or antabuse<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram, better known under the brand name Antabuse, is a drug that for decades has been used as a treatment for alcohol abuse. However, recent research has revealed a promising potential for this drug within cancer treatment. This rediscovery of disulfiram as a potential cancer-fighting agent is an example of how existing drugs can gain new areas of application through a process called repurposing drugs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"How_disulfiram_works_against_cancer\"><\/span>How disulfiram works against cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The precise mechanism by which disulfiram fights cancer is still under intensive research, but it is believed to act in several different ways:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Inhibition of protein degradation<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Cancer cells are dependent on a specific system to break down proteins necessary for their survival. Disulfiram can inhibit this system and thereby prevent cancer cells from growing and dividing.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Immunomodulating<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram has a moderate influence on the immune system. However, this is more pronounced in the repurposed drugs located in this specific group. See group: 1. <a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\">Immunomodulating agents<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Cell cycle and angiogenesis inhibitors<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram affects, to a certain extent, the cell cycle and angiogenesis (formation of new blood vessels).<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Increasing sensitivity to chemotherapy<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram can make cancer cells more sensitive to chemotherapy, which can make the treatment more effective.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Induction of cell death<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram can directly induce cell death in cancer cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_of_disulfiram_against_cancer\"><\/span>Advantages of disulfiram against cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">Safety profile<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Since disulfiram is already approved for the treatment of alcohol abuse, its safety profile is relatively well-known.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Cost-effectiveness<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">As disulfiram is a generic drug, it is relatively inexpensive compared to many new cancer drugs.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Faster development<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Since disulfiram is already approved, it can be developed faster for the treatment of cancer compared to entirely new drugs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects\"><\/span>Side effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Consuming alcohol while undergoing treatment with disulfiram triggers a range of unpleasant symptoms. This is because disulfiram inhibits the breakdown of alcohol in the body.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Common side effects:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fatigue:<\/strong> You may feel more tired than usual.<\/li>\n\n\n\n<li><strong>Headache:<\/strong> Some experience more frequent headaches.<\/li>\n\n\n\n<li><strong>Acne:<\/strong> The skin may become more prone to acne.<\/li>\n\n\n\n<li><strong>Metallic taste in the mouth:<\/strong> Many describe an unpleasant metallic or garlic-like taste.<\/li>\n\n\n\n<li><strong>Sleep disturbances:<\/strong> You may find it difficult to fall asleep or experience restless sleep.<\/li>\n\n\n\n<li><strong>Depression:<\/strong> Some people may experience feelings of sadness or hopelessness.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects_from_alcohol_consumption\"><\/span>Side effects from alcohol consumption<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<h4 class=\"wp-block-heading\">Alcohol-disulfiram reaction<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">If you drink alcohol while in treatment with disulfiram, you may experience a series of serious symptoms, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Flushing of the face and neck<\/li>\n\n\n\n<li>Palpitations<\/li>\n\n\n\n<li>Shortness of breath<\/li>\n\n\n\n<li>Nausea and vomiting<\/li>\n\n\n\n<li>Dizziness<\/li>\n\n\n\n<li>Confusion<\/li>\n\n\n\n<li>Low blood pressure<\/li>\n\n\n\n<li>Seizures<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">In severe cases, it can lead to coma or death. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Liver problems:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In rare cases, disulfiram can cause liver damage. Symptoms of liver damage can include jaundice, dark urine, pale stools, abdominal pain, and fatigue. <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Neurological problems:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In some cases, disulfiram can cause neurological problems such as peripheral neuropathies (nerve damage in arms and legs) that can lead to numbness or tingling.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Other potential side effects<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Allergic reactions:<\/strong> Skin rash, itching, swelling of the face, lips, tongue, or throat.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Psychiatric problems:<\/strong> Anxiety, hallucinations.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Note<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to note that not everyone experiences all these side effects. If you experience any symptoms that cause alarm, you should always contact your doctor or pharmacy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Cancer_types_with_the_best_response_to_disulfiram\"><\/span>Cancer types with the best response to disulfiram<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Some of the cancer types that have proven to be particularly sensitive to disulfiram include:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/hoved-halskraeft\/\"><strong>Head- and <\/strong>neck cancer<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Several studies have shown that disulfiram can improve the effect of radiation therapy in head and neck cancer.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/prostatakraeft\/\">Prostate cancer<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram has shown potential to inhibit the growth of prostate cancer cells and can potentially be combined with other treatments for this disease.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/spiseroerskraeft\/\">Esophageal cancer<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is preliminary evidence that disulfiram can be effective against esophageal cancer, especially when combined with other treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/lungekraeft\/\">Lung cancer<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Some studies suggest that disulfiram can be effective against certain types of lungekr\u00e6ft, especially when combined with chemotherapy.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Note<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to note that these are merely some examples and that individual results may vary. The effectiveness of disulfiram may depend on various factors, such as <a href=\"https:\/\/jegharkraeft.dk\/en\/kraeftformer\/\">the stage of the cancer<\/a>, the patient&#8217;s general health condition, and other factors specific to the individual patient.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Combination_with_other_treatments\"><\/span>Combination with other treatments<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">One of the greatest strengths of disulfiram is its potential to increase the effectiveness of other cancer treatments. Researchers are investigating various combination possibilities, including:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/kemoterapi\/\">Chemotherapy<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram can increase the sensitivity of cancer cells to chemotherapy, meaning a greater effect can be achieved with lower doses of chemotherapy.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/straalebehandling\/\">Radiation therapy<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram can make cancer cells more sensitive to radiation therapy, which can increase the effectiveness of this treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/maalrettet-behandling\/\">Targeted therapy<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram can potentially be combined with targeted therapy designed to attack specific molecular changes in the cancer cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/en\/immunterapi\/\">Immunotherapy<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There is preliminary evidence that disulfiram can strengthen the immune system&#8217;s ability to fight cancer cells, which can make immunotherapy more effective.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">The advantages of combination with other treatments<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Increased effectiveness:<\/strong> The combination of disulfiram with other treatments can lead to a greater reduction in tumor size and longer survival.<\/li>\n\n\n\n<li><strong>Reduced risk of resistance:<\/strong> By combining different treatments, one can decrease the risk of cancer cells developing resistance to a single treatment.<\/li>\n\n\n\n<li><strong>Fewer side effects:<\/strong> In some cases, combination therapy can lead to fewer or less severe side effects compared to treatment with a single agent.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Research\"><\/span>Research<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Several clinical trials have investigated disulfiram&#8217;s effect on various cancer types. The results have been promising, and signs have been seen that disulfiram can:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prolong survival: In some studies, patients treated with disulfiram in combination with other cancer treatment have experienced longer survival.<\/li>\n\n\n\n<li>Reduce tumor size: Disulfiram has been shown to be able to reduce the size of tumors in some patients.<\/li>\n\n\n\n<li>Improve response to other treatment: Disulfiram can increase the effectiveness of other cancer treatments, such as chemotherapy and radiation therapy.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Disulfiram represents an exciting example of how existing drugs can gain new areas of application within cancer treatment. Disulfiram has great potential as a supplement to conventional cancer treatment. By combining disulfiram with other treatments, a more effective and safe treatment of cancer can be achieved. However, it is important to emphasize that there is still a need for more research to uncover the optimal combination possibilities and to identify the patients who will benefit most from this treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">Repurposed Drugs<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b-2\/\">No medicine &#8211; Plan B<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-ef7d07e4a2f3fd4865240f3b1020f6b6 wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-16d169ebe57b1d67eedbc7e418b9c3ca wp-block-paragraph\">[1] <a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noopener\">Interactions (search for preparations)<\/a> (Interaktionsdatabasen, Danish Medicines Agency, n.d.) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A database from the Danish Medicines Agency where you can check for potential interactions between various drugs and supplements.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0610a2916ee7626f4919ded8d4be06f1 wp-block-paragraph\">[2] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39111630\/\" target=\"_blank\" rel=\"noreferrer noopener\">Disulfiram\/copper complex improves the effectiveness of the WEE1 inhibitor Adavosertib in p53 deficient non-small cell lung cancer via ferroptosis<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39197912\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a>(PubMed)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This non-randomized preclinical study describes how a disulfiram\/copper complex improves the effectiveness of a WEE1 inhibitor in lung cancer.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39197912\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e32cd37a76e3a6d886c62649200a16e8 wp-block-paragraph\">[3] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38981152\/\" target=\"_blank\" rel=\"noreferrer noopener\">A strategy of &#8220;adding fuel to the flames&#8221; enables a self-accelerating cycle of ferroptosis-cuproptosis for potent antitumor therapy<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39197912\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a>(PubMed)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This non-randomized preclinical study explores a strategy to accelerate cancer cell death through ferroptosis and cuproptosis.<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39197912\/\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b3cead6bae8ef4d8906f0eed202aadca wp-block-paragraph\">[4] <a href=\"https:\/\/ugeskriftet.dk\/videnskab\/antabus-kan-vaere-farlig\" target=\"_blank\" rel=\"noopener\">Antabus kan v\u00e6re farlig<\/a> (Ugeskrift for L\u00e6ger, n.d.) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article describing potential dangers associated with Antabuse. (Danish language)<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4dccc38a95367fbbea704ddd374b1d1a wp-block-paragraph\">[5] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39385273\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tumor specific in situ synthesis of therapeutic agent for precision cancer therapy<\/a> (PubMed)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This is a non-randomized preclinical study regarding the synthesis of therapeutic agents specifically within tumors.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d34271176349e9c3759e09bd352d7d94 wp-block-paragraph\">[6] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39055020\/\" target=\"_blank\" rel=\"noreferrer noopener\">Programmable &#8220;triple attack&#8221; cancer therapy through in situ activation of disulfiram toxification combined with phototherapeutics<\/a> (PubMed)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A non-randomized preclinical study investigating a &#8220;triple attack&#8221; strategy for cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-a83d53ab8bfc676f1211d0203866f7ac wp-block-paragraph\">[7] <a href=\"https:\/\/www.mdpi.com\/2072-6694\/12\/1\/138\" target=\"_blank\" rel=\"noreferrer noopener\">Disulfiram\/Copper Induces Antitumor Activity against Both Nasopharyngeal Cancer Cells and Cancer-Associated Fibroblasts<\/a> (Cancers, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This is a non-randomized preclinical study describing how the combination of disulfiram and copper (DSF\/Cu) acts lethally on both cancer cells and the surrounding &#8220;helper cells&#8221; (fibroblasts) via oxidative stress and ferroptosis.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ee608f8764fbc5d7c1ea95ce03e3a4d1 wp-block-paragraph\">[8] <a href=\"https:\/\/journals.plos.org\/plosone\/article?id=10.1371\/journal.pone.0251957\" target=\"_blank\" rel=\"noreferrer noopener\">Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model<\/a> (PLOS ONE, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This non-randomized preclinical study supports the claim that disulfiram targets cancer stem cells. It shows how DSF\/Cu specifically targets stem cell markers like ALDH and extends survival in a brain tumor model.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8f96ad78f7b6c6515ef50dfefd8affa9 wp-block-paragraph\">[9] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40491359\/\" target=\"_blank\" rel=\"noopener\">DDTC-Cu(I) Nano-MOF Induces Ferroptosis by Targeting SLC7A11\/GPX4 Signal in Colorectal Cancer<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: This non-randomized preclinical study shows that the nanomedicine Cu-BTC@DDTC, where disulfiram (DSF) is converted into its metabolite, diethyldithiocarbamate (DDTC), embedded in a metal-organic framework, has strong antitumor activity by inhibiting cell growth, migration, and invasion. It works by inducing ferroptosis through the SLC7A11\/GPX4 pathway, making it a promising alternative in cancer treatment through the repurposing of existing drugs.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> October 25, 2024, Last revised June 10, 2025<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Treatments\" >Treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Complementary_and_Alternative_Treatments\" >Complementary and Alternative Treatments<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Disulfiram_Antabuse_against_cancer\" >Disulfiram (Antabuse) against cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#How_disulfiram_works_against_cancer\" >How disulfiram works against cancer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Advantages_of_disulfiram_against_cancer\" >Advantages of disulfiram against cancer<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Side_effects\" >Side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Side_effects_from_alcohol_consumption\" >Side effects from alcohol consumption<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Cancer_types_with_the_best_response_to_disulfiram\" >Cancer types with the best response to disulfiram<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Combination_with_other_treatments\" >Combination with other treatments<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Research\" >Research<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatments Complementary and Alternative Treatments Disulfiram (Antabuse) against cancer What is disulfiram or antabuse Disulfiram, better known under the brand name Antabuse, is a drug that for decades has been used as a treatment for alcohol abuse. However, recent research has revealed a promising potential for this drug within cancer treatment. This rediscovery of disulfiram [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":33142,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[393,375,374,395],"tags":[],"class_list":["post-33143","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-repurposed-drugs","category-alternative-treatments","category-treatments","category-miscellaneous-and-experimental-agents"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33143","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=33143"}],"version-history":[{"count":1,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33143\/revisions"}],"predecessor-version":[{"id":33815,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33143\/revisions\/33815"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/33142"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=33143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=33143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=33143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}