{"id":33116,"date":"2025-03-21T19:25:38","date_gmt":"2025-03-21T18:25:38","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=33116"},"modified":"2026-04-11T18:56:40","modified_gmt":"2026-04-11T17:56:40","slug":"metformin","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/metformin\/","title":{"rendered":"Metformin against cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-98185218a0f40d15d407c89352d14336 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-85c9ab605a9af581478ba1bfba8fd611\"><span class=\"ez-toc-section\" id=\"Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatments-overview\/\">Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-52532d4beacf4a32227a79286a8276fc\"><span class=\"ez-toc-section\" id=\"Complementary_and_Alternative_Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/alternative-cancer-treatments-overview\/\">Complementary and Alternative Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-c16fda6322f9a664a0bc73841a91577c has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-640cf5d71b01b8691f13b6a9a794fcaa\"><a href=\"https:\/\/jegharkraeft.dk\/en\/akupunktur\/\">Physical treatments<\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7802402f9383ffcb53324d876723148d\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Repurposed Drugs &#8211; General<\/mark><\/a>\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-780fac237d6d09f0087842050420bfba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/aspirin\/\">Painkillers and anti-inflammatory drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-fad7d0169f73487a5cb08247fb6344df\"><a href=\"https:\/\/jegharkraeft.dk\/en\/dipyridamole\/\">Heart and circulatory medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-110ab3157ece675d1aeb7921af0e506a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\">Antibiotics and antiparasitic agents<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-173a1d84f796d7acd77bc78289acbdfb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Diabetes medication<\/mark><\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-44e844ac9e21404e0f36ab5f5bff2c71\"><a href=\"#metformin\">Metformin (scroll down)<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6c31e64b006d888e2e94cb9770a3c32c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/low-dose-naltrexone\/\">Agents affecting hormones and signaling substances<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-dd7ca0bc23a9ec3ca6e860ef8de7693a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/\">Other medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-66a0e4204f5201bcc8494f5822b38efe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/the-coc-protocol\/\">COC Protocol<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9504e56e950d068c15963cbdbf1fdaaf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b\/\">No medication \u2013 Plan B<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50bb8d7b4bb216418ba3c0d4a402648c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-chemotherapy\/\">Repurposed drugs and chemotherapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-af88e7f595afd58f141d2c174a141555\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/\">Repurposed drugs and radiation therapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7098df34ebce445cd1790d85e10991eb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/flcccs-ranking\/\">FLCCC\u2019s ranking of repurposed drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c827eb85783b3d07583409effc04d57\"><a href=\"https:\/\/jegharkraeft.dk\/en\/brain-metastases-and-bloodbrain-barrier\/\">Brain metastases and the blood-brain barrier<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-cf6cfac91ed1b7d193bc5d25a711b818\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bombs-fire-extinguishers-and-timing\/\">Bombs, fire extinguishers, and timing<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"500\" height=\"400\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bmetformin.png\" alt=\"Metformin tabletter i hvid og turkis pap\u00e6ske med blisterpakning.\" class=\"wp-image-33115\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bmetformin.png 500w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bmetformin-300x240.png 300w\" sizes=\"auto, (max-width: 500px) 100vw, 500px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bmetformin.png&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-8bddf08b\">\n<h1 class=\"wp-block-heading\" id=\"metformin\"><span class=\"ez-toc-section\" id=\"Metformin_and_cancer\"><\/span>Metformin and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h4 class=\"wp-block-heading\">What is metformin<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Metformin is a drug primarily used for the treatment of type 2 diabetes. It helps lower blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver. Metformin is often the first choice for diabetes treatment and can also have beneficial effects on weight loss and cardiovascular health.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metformin as a <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">repurposed drug<\/a> for cancer is a promising but controversial area. While approved for type 2 diabetes, it has shown potential in the prevention and treatment of certain cancers. However, using metformin for this purpose is considered off-label, as it is not approved by the Medicines Agency for this specific indication. Metformin is included in the <a href=\"https:\/\/fookid.dk\/behandlinger\/coc-protokollen-hvorfor-den-virker\/\" target=\"_blank\" rel=\"noopener\">COC Protocol<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Effect_on_cancer\"><\/span>Effect on cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Metformin may act against cancer by:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reducing insulin levels:<\/strong> High insulin is associated with increased cancer risk; metformin can lower it.<\/li>\n\n\n\n<li><strong>Lowering IGF-1:<\/strong> This hormone promotes the growth of cancer cells; metformin can slow it down.<\/li>\n\n\n\n<li><strong>Dampening inflammation:<\/strong> Inflammation plays a role in cancer development; metformin has anti-inflammatory properties.<\/li>\n\n\n\n<li><strong>Promoting cell death:<\/strong> Metformin can induce death in cancer cells.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_%E2%80%93_anticancer_effect\"><\/span>Advantages \u2013 anticancer effect<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">1. AMPK and Energy Homeostasis:<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The head of the energy factory<\/strong> <strong>AMPK<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>(5&#8242;-AMP-activated protein kinase) is often referred to as the &#8220;head of the cell&#8217;s energy factory.&#8221; When cells experience low energy stores, AMPK is activated, initiating a series of processes to restore energy balance. <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See more about <a href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#metforminampktekst\">AMPK in relation to cancer<\/a> (scroll to)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The high energy consumption of cancer cells<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cancer cells have an extremely high energy consumption to grow and divide rapidly.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">2. The role of Metformin:<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">By activating AMPK, metformin can &#8220;confuse&#8221; cancer cells by signaling that energy levels are low. This can lead to:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Inhibited cell growth:<\/strong> Cancer cells may enter a kind of &#8220;dormancy&#8221; and stop dividing.<\/li>\n\n\n\n<li><strong>Induction of apoptosis:<\/strong> In some cases, metformin can even trigger programmed cell death in cancer cells.<\/li>\n\n\n\n<li><strong>Inhibition of angiogenesis:<\/strong> Metformin can also inhibit the formation of new blood vessels (angiogenesis), which are necessary for tumors to grow.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">3. Other Potential Mechanisms:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Reduction of IGF-1:<\/strong> Metformin can lower levels of insulin-like growth factor 1 (IGF-1), a hormone that stimulates cell growth and survival.<\/li>\n\n\n\n<li><strong>Modulation of the cell cycle:<\/strong> Metformin can affect various proteins involved in regulating the cell cycle, thereby preventing cancer cells from dividing.<\/li>\n\n\n\n<li><strong>Anti-inflammatory effect:<\/strong> Much like statins, metformin can have an anti-inflammatory effect, which may help reduce the growth of cancer cells.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects\"><\/span>Side effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Common side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Metallic taste in the mouth<\/li>\n\n\n\n<li>Diarrhea<\/li>\n\n\n\n<li>Nausea<\/li>\n\n\n\n<li>Vomiting<\/li>\n\n\n\n<li>Stomach pain<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rare side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Lactic acidosis<\/li>\n\n\n\n<li>Low blood sugar<\/li>\n\n\n\n<li>B12 deficiency<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">It should be noted that this is not an exhaustive list of all possible side effects. You can find more information in the package leaflet of your medication. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Metformin is not suitable for everyone. People with kidney or liver disease, type 1 diabetes, acidosis, or serious infection should not take it.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Research\"><\/span>Research<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Studies suggest that metformin can:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Alleviate symptoms such as:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fatigue, weight loss.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Reduce the risk of:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Breast cancer, colorectal cancer, pancreatic cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Improve survival in:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cancer patients.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Increase the effectiveness of:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Chemotherapy and radiation therapy.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Note\"><\/span>Note<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The decision to use metformin for cancer is made in consultation with a physician who has a deep understanding of your medical history, risk profile, and treatment goals. Off-label use of medication is not part of <a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatment-guidelines\/\">the standard clinical guidelines for cancer<\/a> (Danish version), and it is important to be well-informed about the benefits and risks before making a decision.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Metformin, originally developed for diabetes treatment, has shown promising potential as an anticancer agent. By affecting cellular energy consumption and regulating various cellular processes, metformin can inhibit the growth of cancer cells and potentially improve patient survival. Furthermore, be aware that certain drugs can interact, leading to unintended effects when combined.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If in doubt, it can be checked here:<\/p>\n\n\n\n<p class=\"has-custom-bl-links-color has-text-color has-link-color wp-elements-44e9f8537547201e0b860469b007bb4f wp-block-paragraph\"><a href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\" rel=\"noreferrer noopener\">Drugs.com<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">Repurposed Drugs<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b-2\/\">No medicine &#8211; Plan B<\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-ef7d07e4a2f3fd4865240f3b1020f6b6 wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7b69e5324021d3ca9c1ab2aa6ac2b0d7 wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noreferrer noopener\">Interaktioner <\/a>(search for preparations) (Danish Medicines Agency) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ee8a5284eff4e3af7f9aa805cc04cde7 wp-block-paragraph\"><a href=\"https:\/\/medicinsktidsskrift.dk\/behandlinger\/kraeft\/254-metformin-reducerer-kraeftrisiko.html\" target=\"_blank\" rel=\"noopener\">Medical Journal <\/a>(Metformin reduces cancer risk) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b07813815135efb49f2f608524eacd5e wp-block-paragraph\"><a href=\"https:\/\/dagensmedicin.dk\/diabetesmiddel-kan-nedsatte-risiko-for-brystkraft\/\" target=\"_blank\" rel=\"noreferrer noopener\">Dagens Medicin<\/a> (Diabetes drug lowers risk of breast cancer) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1050729d679d82ab1b0f87e259f49b39 wp-block-paragraph\"><a href=\"https:\/\/nordjyske.dk\/nyheder\/nordjylland\/nordjysk-forskning-slaar-fast-diabetespille-beskytter-mod-kraeft\/5075032\" target=\"_blank\" rel=\"noreferrer noopener\">Nordjyske<\/a> (Diabetes pill slows cancer) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-25fc8be262f3a1a0b4a7885154e7f84a wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28258677\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metformin &#8211; its potential anti-cancer and anti-aging effects<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3be332bb59e5555e7f8fd8fb4fd4fda0 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/27681864\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metformin as an adjuvant treatment for cancer: a systematic review and meta-analysis<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0b5a517120ee7b5f33504096ad08bff9 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31831021\/\" target=\"_blank\" rel=\"noreferrer noopener\">Metformin in colorectal cancer: molecular mechanism, preclinical and clinical aspects <\/a>(PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-a5da7caa4fc784bbbc0d7d61fea66122 wp-block-paragraph\"><a href=\"https:\/\/www.technologynetworks.com\/drug-discovery\/articles\/metformin-may-play-a-surprising-role-in-radiation-protection-390949?fbclid=IwY2xjawFSn9RleHRuA2FlbQIxMQABHb-fBquijOlonMB8UKiaMrIfUdGlxUJZcTdD4mOmAhm3-T9Hjzk8TZ8-bA_aem_uh5sdsZzwMQqYNpSWfPJ-Q\" target=\"_blank\" rel=\"noreferrer noopener\">Metformin May Play a Surprising Role in Radiation Protection<\/a> (Technology Networks)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b185824e37d7c51d96a22b9975b44425 wp-block-paragraph\"><a href=\"https:\/\/academic.oup.com\/abbs\/article\/50\/2\/133\/4371596?login=false\" target=\"_blank\" rel=\"noopener\">Metformin as an anti-cancer agent: actions and mechanisms targeting cancer stem cells<\/a> (Oxford Academic 2017)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance<\/strong>: Metformin, a widely used diabetes medication, has been shown to act against cancer by disrupting cellular metabolism and blocking key growth pathways such as mTOR. Research focuses on its ability to target resistant cancer stem cells that drive spread and recurrence. This is a non-randomized review.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-96844603d598be263332c67b52bd9b40 wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10286395\/\" target=\"_blank\" rel=\"noopener\">Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing<\/a> (PubMed, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance<\/strong>: Metformin, a safe and inexpensive diabetes drug, has been shown to decrease cancer risk and mortality. Its anti-cancer effect works in two ways: indirectly by improving overall metabolism and directly by attacking the energy metabolism of cancer cells. This is a non-randomized review.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-6d732e3f71d94d36d4720e80b10f7bd6 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40466285\/\" target=\"_blank\" rel=\"noopener\">An exploration of molecular signaling in drug reprocessing for Oral Squamous Cell Carcinoma<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance<\/strong>: Metformin is a known repurposed drug with documented anticancer effects, particularly in the treatment of oral squamous cell carcinoma (OSCC). It works through various molecular signaling pathways, making it a valuable supplement in cancer therapy. This is a non-randomized study.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-99d71072139a739434b696db002be3b6 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40471105\/\" target=\"_blank\" rel=\"noopener\">Metformin Enhances PD-L1 Inhibitor Efficacy in Ovarian Cancer by Modulating the Immune Microenvironment and RBMS3 Expression<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance<\/strong>: Metformin can strengthen the immune system in ovarian cancer by increasing CD8+ T-cells and reducing PD-L1. When used with PD-L1 inhibitors, treatment is improved, though RBMS3 is important for this effect. This is a non-randomized preclinical study.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d46e1b46b43176a8c447b18bec2f3dc0 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40252335\/\" target=\"_blank\" rel=\"noopener\">Neratinib and metformin: A novel therapeutic approach against HER2-Positive Breast Cancer<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance<\/strong>: The combination of neratinib and metformin reduces cancer cell growth, disrupts the cell cycle, and inhibits invasion and angiogenesis in HER2-positive breast cancer. They affect several important signaling pathways. This is a non-randomized preclinical study.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-47f448234c3a2079406419477b668061 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40216262\/\" target=\"_blank\" rel=\"noopener\">The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance<\/strong>: Metabolic syndrome increases the risk of cancer, especially in the gastrointestinal tract. Medications like metformin and statins can prevent cancer and improve prognosis, opening possibilities for new combination therapies. This is a non-randomized review.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8ee414b3391307bb00c251e2742177ad wp-block-paragraph\"><a href=\"https:\/\/www.mdpi.com\/1648-9144\/61\/6\/1021\" target=\"_blank\" rel=\"noopener\">Metformin: A Dual-Role Player in Cancer Treatment and Prevention: A Comprehensive Systematic Review and Meta-Analysis <\/a>(MDPI, Cancers, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: This meta-analysis of 112 studies shows that metformin is associated with a significantly lower cancer risk and reduced mortality in cancer patients. The results support its potential as a supplement to standard care. This is a non-randomized systematic review.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-cdcd7427884af6009333aa59b766d4fc wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC12087300\/\" target=\"_blank\" rel=\"noopener\">Targeting Cancer Stem Cells and Hedgehog Pathway by Metformin and Cisplatin Combination in Ovarian Cancer<\/a> (PMC, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: A laboratory study showing exactly how metformin and a type of platinum-based chemotherapy (cisplatin) work together to induce programmed cell death (apoptosis) in ovarian cancer cells. This is a non-randomized preclinical study.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8070f61201e796052e7a9bb8fdb61f72 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40105683\/\" target=\"_blank\" rel=\"noopener\">Tolerability, safety and feasibility of metformin combined with chemoradiotherapy in patients with locally advanced cervical cancer: A phase II, randomized study<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: Shows that it is safe and feasible to combine metformin with chemo\/radiation in a similar patient group (gynecological cancer). This is a randomized Phase II study.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4789ea0ca89bdb93e9079f17372a83d6 wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7497683\/\" target=\"_blank\" rel=\"noopener\">Phase I study of metformin in combination with carboplatin\/paclitaxel chemotherapy in patients with advanced epithelial ovarian cancer <\/a>(PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: A safety study establishing the correct dose and confirming that it is safe to combine metformin with Carboplatin-based chemotherapy. This is a non-randomized Phase I study.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-db2956b5a017437cbfb7938465067041 wp-block-paragraph\"><a href=\"https:\/\/www.researchgate.net\/publication\/388848700_Metformin_for_patients_with_advanced_stage_ovarian_cancer_A_randomized_phase_II_placebo-controlled_trial\" target=\"_blank\" rel=\"noopener\">Metformin for patients with advanced stage ovarian cancer: A randomized phase II placebo-controlled trial <\/a>(Research Gate, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: A high-quality study confirming metformin&#8217;s effect in patients with advanced ovarian cancer. This is a randomized, placebo-controlled Phase II trial.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d09e612d7b1831a1899b3c6e4e16ddbc wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S193652332500169X\" target=\"_blank\" rel=\"noopener\">The clinical potentials of combining paclitaxel-based chemotherapy regimen with metformin in cancer treatment: A systematic review and Meta-analysis<\/a> (Science Direct, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: A review article gathering knowledge on metformin&#8217;s positive effect along with a type of chemotherapy (Taxol\/Paclitaxel) that the patient has previously received. This is a non-randomized systematic review.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-fbf0af01a1cd1a219470714faa7573ae wp-block-paragraph\"><a href=\"https:\/\/www.frontiersin.org\/journals\/oncology\/articles\/10.3389\/fonc.2023.1176885\/full\" target=\"_blank\" rel=\"noopener\">Efficacy and safety of metformin in combination with chemotherapy in cancer patients without diabetes: systematic review and meta-analysis<\/a> (Frontiers, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content<\/strong>: A review article confirming that metformin is effective and safe for cancer patients who do not already have diabetes. This is a non-randomized systematic review and meta-analysis.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> July 2, 2024, Last revised September 16, 2025<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;http:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bCelecoxib.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h2 class=\"wp-block-heading\" id=\"celecoxib-noerdede\"><span class=\"ez-toc-section\" id=\"AMPK_%E2%80%93_A_bit_nerdy\"><\/span>AMPK &#8211;<br>A bit nerdy<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h4 class=\"wp-block-heading\">What is AMPK<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">AMPK, or 5&#8242;-AMP-activated protein kinase, is a central enzyme in the cell&#8217;s energy metabolism. It functions as a kind of &#8220;energy sensor&#8221; that constantly monitors the cell&#8217;s energy status. When the cell experiences energy deficiency, the concentration of AMP (adenosine monophosphate) increases, which is a signal that more energy is needed.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"AMPK_upon_activation\"><\/span><strong>AMPK upon activation<\/strong> <span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">When AMPK is activated by the rising level of AMP, it initiates a series of processes to increase the production of ATP (adenosine triphosphate), the cell&#8217;s energy currency. Some of the most important effects of AMPK activation include:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Inhibition of the mTOR signaling pathway<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>mTOR is an important regulator of cell growth and proliferation. AMPK inhibits mTOR, which can slow down cell growth and division.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Stimulation of glucose uptake<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AMPK increases the cell&#8217;s uptake of glucose from the blood, so more &#8220;fuel&#8221; is available to produce ATP.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Increased fatty acid oxidation<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AMPK stimulates the breakdown of fatty acids, which can be used as an energy source.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Inhibition of fatty acid and cholesterol synthesis<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>When the cell needs energy, it is not the time to build new fat stores. AMPK therefore inhibits the processes leading to the synthesis of fatty acids and cholesterol.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Activation of autophagy<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AMPK can induce autophagy, a process where the cell breaks down and recycles unnecessary or damaged components. This can be a way for the cell to obtain energy under stress.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"AMPK_and_cancer\"><\/span>AMPK and cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Growth and proliferation<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As mentioned earlier, cancer cells have very high energy consumption. By activating AMPK and thereby &#8220;fooling&#8221; the cancer cells into believing there is an energy deficiency, one can potentially inhibit their growth and proliferation (proliferation means that cells divide and increase in number). This is one of the mechanisms by which metformin is believed to have an anticancer effect.<a href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\" rel=\"noreferrer noopener\"><\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion-2\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">AMPK plays a crucial role in the cell&#8217;s energy metabolism. By functioning as a sensor for the cell&#8217;s energy status, AMPK can coordinate a variety of processes to maintain energy balance. AMPK&#8217;s role in cancer research is an active area of research, and there are high expectations that a deeper understanding of AMPK&#8217;s function can lead to new cancer treatments.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><strong>Repurposed Drugs<\/strong><\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-ef7d07e4a2f3fd4865240f3b1020f6b6 wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4be4931760db72145daf81dd77210cf3 wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC209533\/\" target=\"_blank\"><strong>Role of AMP-activated protein kinase in mechanism of metformin action<\/strong><\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1e534ecea45b58bb2d45c91510a29bf9 wp-block-paragraph\"><a href=\"https:\/\/nexs.ku.dk\/arrangementer\/arkiv\/2012\/phd_jonas_mk\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Ph.d. forsvar: Role of metformin in regulation of AMPK activation, glucose uptake<\/strong><\/a> (Department of Nutrition, Exercise and Sports)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> July 2, 2024, Last revised November 1, 2024<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Treatments\" >Treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Complementary_and_Alternative_Treatments\" >Complementary and Alternative Treatments<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Metformin_and_cancer\" >Metformin and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Effect_on_cancer\" >Effect on cancer<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Advantages_%E2%80%93_anticancer_effect\" >Advantages \u2013 anticancer effect<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Side_effects\" >Side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Research\" >Research<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Note\" >Note<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#AMPK_%E2%80%93_A_bit_nerdy\" >AMPK &#8211; A bit nerdy<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#AMPK_upon_activation\" >AMPK upon activation<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#AMPK_and_cancer\" >AMPK and cancer<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/#Conclusion-2\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatments Complementary and Alternative Treatments Metformin and cancer What is metformin Metformin is a drug primarily used for the treatment of type 2 diabetes. It helps lower blood sugar levels by improving insulin sensitivity and reducing glucose production in the liver. Metformin is often the first choice for diabetes treatment and can also have beneficial [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":33115,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[393,375,374,394],"tags":[],"class_list":["post-33116","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-repurposed-drugs","category-alternative-treatments","category-treatments","category-cell-cycle-and-angiogenesis-inhibitors"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33116","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=33116"}],"version-history":[{"count":1,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33116\/revisions"}],"predecessor-version":[{"id":33832,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33116\/revisions\/33832"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/33115"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=33116"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=33116"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=33116"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}