{"id":33036,"date":"2025-03-21T19:27:36","date_gmt":"2025-03-21T18:27:36","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=33036"},"modified":"2026-06-06T10:14:18","modified_gmt":"2026-06-06T09:14:18","slug":"mebendazole","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/mebendazole\/","title":{"rendered":"Vermox. Mebendazole and cancer. Benzimidazoles. Repurposed drugs. Antiparasitic agents."},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-a159696e32d614ac638db3c1b1625a94 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-85c9ab605a9af581478ba1bfba8fd611\"><span class=\"ez-toc-section\" id=\"Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatments-overview\/\">Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-52532d4beacf4a32227a79286a8276fc\"><span class=\"ez-toc-section\" id=\"Complementary_and_Alternative_Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/alternative-cancer-treatments-overview\/\">Complementary and Alternative Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-07676263e12697e3baeaa986f49b9094 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-ff924a978a8de8fd490d8d0b5dae60c7\"><a href=\"https:\/\/jegharkraeft.dk\/akupunktur\/\">Physical treatments<\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-87305be176115f06efff8b3c48266fba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Repurposed Drugs &#8211; General<\/mark><\/a>\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-780fac237d6d09f0087842050420bfba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/aspirin\/\">Painkillers and anti-inflammatory drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-fad7d0169f73487a5cb08247fb6344df\"><a href=\"https:\/\/jegharkraeft.dk\/en\/dipyridamole\/\">Heart and circulatory medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a8b32647577a1e1e5a1b25b8580ffcfe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Antibiotics and antiparasitic agents<\/mark><\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-e87df1a7a6119779a4006c75b78b460e\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\">Doxycycline<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-5311555f3d0b0aeaed276a15e6d41095\"><a href=\"https:\/\/jegharkraeft.dk\/en\/fenbendazole\/\">Fenbendazole<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/\">Ivermectin<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-f7193c34832c2c436af2fc7d432738f8\"><a href=\"#mebendazole\">Mebendazole (scroll down)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/niclosamide\/\">Niclosamide<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/plaquenil\/\">Plaquenil<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-e14efef0d84b049fbd10356aa59a17d5\"><a href=\"#mebendazole\">Vermox (scroll down)<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a99575c8ffb4e827783ab6d56f16ed45\"><a href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/\">Diabetes medication<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6c31e64b006d888e2e94cb9770a3c32c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/low-dose-naltrexone\/\">Agents affecting hormones and signaling substances<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-dd7ca0bc23a9ec3ca6e860ef8de7693a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/\">Other medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-66a0e4204f5201bcc8494f5822b38efe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/the-coc-protocol\/\">COC Protocol<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9504e56e950d068c15963cbdbf1fdaaf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b\/\">No medication \u2013 Plan B<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50bb8d7b4bb216418ba3c0d4a402648c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-chemotherapy\/\">Repurposed drugs and chemotherapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-af88e7f595afd58f141d2c174a141555\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/\">Repurposed drugs and radiation therapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7098df34ebce445cd1790d85e10991eb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/flcccs-ranking\/\">FLCCC\u2019s ranking of repurposed drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c827eb85783b3d07583409effc04d57\"><a href=\"https:\/\/jegharkraeft.dk\/en\/brain-metastases-and-bloodbrain-barrier\/\">Brain metastases and the blood-brain barrier<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-cf6cfac91ed1b7d193bc5d25a711b818\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bombs-fire-extinguishers-and-timing\/\">Bombs, fire extinguishers, and timing<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1500\" height=\"992\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1.jpg\" alt=\"Vermox symboliseret ved hvid papemballage med p\u00e5skriften Vermox, 30 ml.\" class=\"wp-image-33034\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1.jpg 1500w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1-600x397.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1-300x198.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1-1024x677.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1-768x508.jpg 768w\" sizes=\"auto, (max-width: 1500px) 100vw, 1500px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bvermox1.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 id=\"mebendazole\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mebendazole_%E2%80%93_Vermox_and_cancer\"><\/span>Mebendazole &#8211; Vermox and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Content:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"#mebendazol-tekst\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Mebendazole_%E2%80%93_Vermox_and_cancer\">Mebendazole \u2013 Vermox and cancer<\/a> (scroll ned)<\/li>\n\n\n\n<li><a href=\"#parasitaere-sammenholdt\"><\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Antiparasitic_drugs_%E2%80%93_compariso\">Antiparasitic drugs \u2013 compariso<\/a> (scroll to)<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_are_Vermox_and_Mebendazole\"><\/span>What are Vermox and Mebendazole<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Vermox is a brand name for the drug mebendazole, which is an antiparasitic agent. It is used to treat infections caused by various types of worms, including tapeworms and roundworms. Mebendazole works by preventing the worms&#8217; ability to absorb glucose, leading to their death. It is effective for treating intestinal parasitic infections and is generally well-tolerated with few side effects.<br>Vermox (Mebendazole) used as a <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">repurposed drug<\/a> in cancer treatment shows promising results in research.<br>The effect may be due to certain similarities between the survival mechanisms of cancer cells and parasites, but it is important to note that cancer is a complex disease with many different facets.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/mebendazole-forskning\/\">Mebendazole inhibits the spread of cancer<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Important_about_absorption\"><\/span>Important about absorption<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"has-custom-menu-links-background-color has-background wp-block-paragraph\"><strong>Fenbendazole and mebendazole are highly lipophilic (fat-loving) substances. Since they are poorly absorbed on an empty stomach, studies show that their absorption into the bloodstream is significantly increased if taken with a high-fat meal. This is crucial for achieving an effect in the body\u2019s cells. See the overview of fat-rich foods below.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To get the substance absorbed into the bloodstream, where it needs to fight cancer cells, it&nbsp;<strong>must be<\/strong>&nbsp;taken with a high-fat meal (a minimum of 40g of fat is optimal, but less can be sufficient).<br>Without fat, most of it just passes through the system. See the bottom of the article.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"The_difference\"><\/span>The difference<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">It is essential to know the difference between treating worms and treating cancer, as the strategies are diametrically opposed:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Against worms:<\/strong> Here, you want the medicine to stay in the intestine to kill the worms locally. Therefore, the pill is often\/best taken without food.<\/li>\n\n\n\n<li><strong>Against cancer:<\/strong> Here, the medicine must leave the intestine and be absorbed into the bloodstream so it can be transported to the tumor.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Mebendazole is absorbed extremely poorly by the body on its own. It is a fat-soluble substance. Clinical data show that if taken without fat, almost all of it is excreted again without reaching the bloodstream. To &#8220;force&#8221; the substance into the blood, it MUST be taken with a high-fat meal (minimum 10-15 grams of fat, e.g., eggs, nuts, avocado, or olive oil). Without dietary fat, the bioavailability is near zero in relation to cancer treatment.<\/p>\n\n\n\n<h2 id=\"mebendazol-tekst\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Parasites_vs_cancer_%E2%80%93_similarities\"><\/span>Parasites vs. cancer &#8211; similarities<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Circumvention of the immune system<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both cancer cells and parasites can develop mechanisms to avoid attacks from the immune system. Cancer cells can, for example, hide from immune cells by changing their surface markers or secreting substances that suppress the immune response. Parasites can also use similar strategies to avoid being killed by the host organism&#8217;s immune system.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Attack on the host environment<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both cancer cells and parasites can damage and exploit their host organism. Cancer cells can invade and destroy healthy tissue, while parasites can cause disease and weakening of the host.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Metastases<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Certain types of cancer cells can spread to other parts of the body and establish new tumors, a process known as metastasis. Parasites can also spread to different locations in the host organism and cause infections in various organs.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Advantages_as_off-label\"><\/span>Advantages as off-label<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Preclinical studies<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Numerous preclinical studies have shown Mebendazole&#8217;s potential to target various types of cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Patient reports<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Although the number is limited, there are patient reports showing anticancer effects against cancer in humans.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Inhibits microtubules<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vermox disrupts the formation of microtubules, which are important for the growth and division of both worms and cancer cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Causes cell death<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>This disruption leads to the death of the worms\/cancer cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Angiogenesis inhibition<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Some studies suggest that Vermox can inhibit the formation of new blood vessels (angiogenesis), which are necessary for tumors to grow and spread.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Immunomodulatory effect<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>There are several indications that Vermox can affect the immune system and potentially strengthen the body&#8217;s own ability to fight cancer cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Selective toxicity<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Vermox is relatively selective toward rapidly dividing cells, such as cancer cells and worms. This may make it less toxic to normal cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Synergy with existing treatments<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Research suggests that Mebendazole can act synergistically with existing cancer treatments, potentially improving outcomes. Not least when used in combination with other repurposed drugs.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Relatively safe and inexpensive<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Mebendazole has a well-established safety profile for approved use and is a relatively inexpensive medication. Especially compared to many chemotherapeutic agents, Vermox has an extremely low toxicity profile.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects\"><\/span>Side effects<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">As with all medicine, Vermox can cause side effects, although not everyone experiences them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Common side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Stomach pain:<\/strong> This is one of the most common side effects and can feel like cramps or discomfort in the stomach.<\/li>\n\n\n\n<li><strong>Diarrhea:<\/strong> Loose stools or increased bowel movements are also common.<\/li>\n\n\n\n<li><strong>Flatulence:<\/strong> Increased gas in the intestines can lead to increased flatulence.<\/li>\n\n\n\n<li><strong>Nausea and vomiting:<\/strong> Some people may experience nausea or vomiting after taking Vermox.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Less common side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Abdominal discomfort:<\/strong> This can feel like a general unease in the stomach.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Furthermore, the following may occur:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Headache<\/li>\n\n\n\n<li>Dizziness.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Allergic reactions:<\/strong> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In rare cases, Vermox can trigger allergic reactions, which may include rash, itching, swelling of the face, lips, or tongue, and difficulty breathing.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Rare side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Liver problems:<\/strong> In very rare cases, Vermox can affect the liver.<\/li>\n\n\n\n<li><strong>Seizures:<\/strong> Especially in small children, there have been reports of seizures after using Vermox.<\/li>\n\n\n\n<li><strong>Blood disorders:<\/strong> Changes in the composition of the blood may occur, such as a decreased number of certain types of white blood cells.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Contact a doctor<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">If you experience serious side effects or side effects not described in this information, contact your doctor or pharmacy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antiparasitic_agents\"><\/span>Antiparasitic agents<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Why antiparasitic agents can have an effect on cancer cells:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Analogous (related) biological processes<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cell division<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both cancer cells and parasites divide rapidly, and agents that disrupt cell division can have an effect on both.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Metabolism<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both cancer cells and some parasites have high metabolic activity to grow and divide rapidly. Agents such as Fenbendazole, Vermox, and Plaquenil can affect specific metabolic pathways that are important for both cancer cells and parasites.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Protein synthesis<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Both cancer cells and parasites produce a variety of proteins necessary for their survival and spread. Some of these proteins may have analogous structures or functions; therefore, agents that inhibit protein synthesis in parasites can also affect cancer cells.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Indirect effects<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Awakening dormant immune cells<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cancer cells are skilled at &#8220;shutting down&#8221; our immune system. Parasites can help &#8220;awaken&#8221; these dormant immune cells so they can again recognize and attack the cancer cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Microenvironment<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Parasites can affect the microenvironment where cancer cells are located. By removing parasites, one can change this microenvironment and make it less favorable for cancer cell growth.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Activation of the immune system<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Some parasites have an ability to stimulate and activate our immune system in a way that makes it more effective at fighting diseases, including cancer cells. Paradoxically, antiparasitic agents can thus strengthen this immune response and thereby indirectly have a cancer-suppressing effect.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Is parasitic infection then a good thing<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Why do we take antiparasitic drugs but research parasites for the treatment of cancer? It is not a contradiction. Researchers try to utilize the positive aspects of parasites without exposing humans to the negative consequences of an infection. This can be done by:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Isolating the active substances<\/strong> Researchers attempt to isolate specific substances in parasites that have a positive effect on the immune system and develop drugs based on these substances.<\/li>\n\n\n\n<li><strong>Genetically modified parasites<\/strong> Work is being done to develop genetically modified parasites that only possess the desired properties and do not cause disease.<\/li>\n\n\n\n<li><strong>Combination treatment<\/strong> Parasites can potentially be used in combination with existing cancer treatments to increase effectiveness.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>While we wait<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The result of this research lies somewhere in the future. Personally, I do not dare wait for that, so I have chosen a repurposed drug in the form of Vermox (in combination with other repurposed drugs).<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Note<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">It is important to have a nuanced understanding of parasites. While some parasites can have positive effects on our health, most parasites are harmful and can cause serious diseases. Research in this area is still in its infancy, and it is important to be critical of the information one finds.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Although there are promising results from laboratory experiments, large clinical trials confirming that Vermox (mebendazole) is a safe and effective treatment for cancer are still lacking (as with all other off-label repurposed drugs). Until that happens (if ever), Vermox is unlikely to become part of conventional treatment. However, this does not change the beneficial effect it has for those who use it as an adjuvant cancer treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To fully exploit Vermox&#8217;s potential, it is necessary to understand how the substance works on cancer cells and how it is best combined with other treatments. It can be particularly beneficial to look at cancer&#8217;s pathways and attempt to close all of these as best as possible with relevant measures. Here, Vermox works by closing off one pathway.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, be aware that certain drugs can interact, potentially causing unintended effects when combined. If you wish to use Vermox for your cancer, discuss the benefits and risks with your practitioner.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fat-rich_foods_with_a_high_content_of_healthy_fat\"><\/span>Fat-rich foods with a high content of healthy fat<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Here is an overview of how you can easily reach either 20 grams or 40 grams of fat through common food items. The specified amounts are approximate, as the exact content may vary slightly depending on the product.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nuts and almonds<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nuts have a very high content of unsaturated fat and are one of the easiest ways to increase fat intake without having to eat large quantities.<br><strong>To get 20 g of fat:<\/strong> Eat a small handful (approx. 35 grams) of almonds or walnuts.<br><strong>To get 40 g of fat:<\/strong> Eat two small handfuls (approx. 70 grams) of almonds or walnuts.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Plant oils<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cooking oil such as olive oil or rapeseed oil is pure fat, which makes it highly effective for enriching meals.<br><strong>To get 20 g of fat:<\/strong> Use 1.5 tablespoons (approx. 22 milliliters) of oil in cooking or as a dressing.<br><strong>To get 40 g of fat:<\/strong> Use 3 tablespoons (approx. 44 milliliters) of oil distributed over the day&#8217;s meals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Avocado<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Avocado contains large amounts of healthy, monounsaturated fat.<br><strong>To get 20 g of fat:<\/strong> Eat 1 large avocado (or 1.5 smaller avocados).<br><strong>To get 40 g of fat:<\/strong> Eat 2 large avocados.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Peanut butter and other nut milks or butters<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Peanut butter is dense in both calories and fat, and it works well on bread or in smoothies.<br><strong>To get 20 g of fat:<\/strong> Eat 1.5 tablespoons (approx. 40 grams) of peanut butter.<br><strong>To get 40 g of fat:<\/strong> Eat 3 tablespoons (approx. 80 grams) of peanut butter.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Dairy products and cheese<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dairy products and hard cheeses are concentrated sources of fat, which makes them particularly effective for increasing fat intake.<br><strong>To get 20 g of fat:<\/strong> Eat 1.5 deciliters of Greek yogurt (10% fat), 125 grams of cr\u00e8me fra\u00eeche (18% fat), 60 grams of hard cheese (e.g., Danbo 45+ or matured cheddar), or consume 0.6 deciliters of whipping cream (38% fat).<br><strong>To get 40 g of fat:<\/strong> Eat 3 deciliters of Greek yogurt (10% fat), 250 grams of cr\u00e8me fra\u00eeche (18% fat), 120 grams of hard cheese (e.g., Danbo 45+ or matured cheddar), or consume 1.2 deciliters of whipping cream (38% fat).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fatty fish<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fish such as salmon, mackerel, and herring contribute important omega-3 fatty acids in addition to fat.<br><strong>To get 20 g of fat:<\/strong> Eat about 130 grams of oven-baked salmon or a small can of mackerel in tomato sauce.<br><strong>To get 40 g of fat:<\/strong> Eat a large salmon fillet of about 250 grams.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are in doubt, it can be checked here:<\/p>\n\n\n\n<p class=\"has-custom-bl-links-color has-text-color has-link-color wp-elements-e5573d2edb548cbf9a683e50be6153ba wp-block-paragraph\"><a rel=\"noreferrer noopener\" href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\"><strong>Drugs.com<\/strong><\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/mebendazole-forskning\/\">Mebendazole inhibits the spread of cancer<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"#mitochondrielle-teorien\">Cancer treatment based on the Mitochondrial Stem Cell Connection<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/parasittens-vej-til-kraeft\/\">The parasite&#8217;s path to cancer<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">Repurposed Drugs<\/a> <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b-2\/\">No medicine &#8211; Plan B<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>To be continued&#8230;<\/strong><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8f64470dbd6f70331b017b0d6414476f wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noreferrer noopener\">Interaktioner <\/a>(search for preparations) (Interaktionsdatabasen, Danish Medicines Agency) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e8ffd92d3c372aa71d43157989c29018 wp-block-paragraph\"><a href=\"https:\/\/www.onedaymd.com\/2025\/04\/fenbendazole-ivermectin-mebendazole-breast-cancer.html?m=1&amp;fbclid=IwY2xjawLLzjlleHRuA2FlbQIxMQBicmlkETB6Z3JmcTBiVjE3aWZsOVk1AR6YqtGVRRh4AKT27Xbrs1D-ZnsZhEUm0JA-kHYlQMSGDKJLlqcqwdjGKleXxA_aem_4liz50FMI2Lok_3mycN_Kw\" target=\"_blank\" rel=\"noopener\">Fenbendazole, Ivermectin and Mebendazole for Breast Cancer Success Stories \u2013 37 Case Reports<\/a> (The Medical Adviser, June 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Several peer-reviewed articles and case studies suggest that Fenbendazole, Ivermectin, and Mebendazole may play an important role in the treatment of stage 4 breast cancer. Research shows that these substances have different anti-cancer mechanisms that can be effective against cancer cells. Specific studies include a protocol for Ivermectin, as well as investigations of Fenbendazole and Mebendazole in relation to breast cancer and metastases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e659719d35b2f2e9f1aa42dd14fa7617 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25075217\/\" target=\"_blank\" rel=\"noopener\">Repurposing Drugs in Oncology (ReDO)\u2014mebendazole as an anti-cancer agent<\/a> (PubMed, 2014)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Mebendazole, a well-known anthelmintic drug, has anti-cancer properties that have been investigated in preclinical studies and two human case reports. It is suggested that mebendazole can synergize with other drugs, including chemotherapeutics. Further research into its potential as an anti-cancer therapeutic is needed, and possible combinations with other drugs are discussed.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-76375ccf41e4eef9f8f9a264f0dabb57 wp-block-paragraph\"><a href=\"https:\/\/www.nature.com\/articles\/s41598-021-88433-y\" target=\"_blank\" rel=\"noreferrer noopener\">Scientific Reports<\/a> (mebendazole in patients with advanced gastrointestinal cancer)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3ad3475293072092c4b893fbe5e54c71 wp-block-paragraph\"><a href=\"https:\/\/www.tidslerne.dk\/index.php\/2020\/11\/12\/repurposed-drugs\/\" target=\"_blank\" rel=\"noreferrer noopener\">Tidslerne<\/a> (Reporposed drugs) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4693a0b19644a61b77ecaabb507795c9 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34218593\/\" target=\"_blank\" rel=\"noreferrer noopener\">Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4e4e93e46a082449998557ee6846a339 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33131904\/\" target=\"_blank\" rel=\"noreferrer noopener\">Potential and mechanism of mebendazole for treatment and maintenance of ovarian cancer<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c46d2f2d4ca1782c6f19f6913b9379dc wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32781060\/\" target=\"_blank\" rel=\"noreferrer noopener\">Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c763ee772a1efc9efbecb02a69753541 wp-block-paragraph\"><a href=\"https:\/\/www.rjptonline.org\/HTMLPaper.aspx?Journal=Research%20Journal%20of%20Pharmacy%20and%20Technology;PID=2025-18-4-23\" target=\"_blank\" rel=\"noreferrer noopener\">Repurposing of Mebendazole as an Anticancer Agent: A Review<\/a> (Research Journal of Pharmacy and Technology, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This is a recent review article summarizing mebendazole&#8217;s mechanisms of action, including how it stops cell division, prevents blood vessel formation (angiogenesis), and induces programmed cell death (apoptosis) in a wide range of cancers.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-66622d84b670bb072cf5d0af97d08254 wp-block-paragraph\"><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3158014\/\" target=\"_blank\" rel=\"noreferrer noopener\">Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme<\/a> (Neuro-Oncology via PMC, 2011)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> A specific and highly cited preclinical study showing how both fenbendazole and mebendazole have an effect against glioblastoma (brain cancer) in animal models, primarily by disrupting the cells&#8217; microtubule structure.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-6fe9b2d022a56bf9781cf37e400d3200 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39851541\/\" target=\"_blank\" rel=\"noopener\">Mebendazole Exerts Anticancer Activity in Ovarian Cancer Cell Lines via Novel Girdin-Mediated AKT\/IKK\u03b1\/\u03b2\/NF-\u03baB Signaling Axis<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Mebendazole (MBZ) inhibits growth, migration, and cancer stem cells in ovarian cancer cells by disrupting the cytoskeleton and blocking Akt\/NF-\u03baB pathways. It induces cell cycle arrest and apoptosis, making it a promising treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-68cbf8a69d99fed7376bb128eeac89da wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39566281\/\" target=\"_blank\" rel=\"noopener\">Transcriptome analysis displays new molecular insights into the mechanisms of action of Mebendazole in gastric cancer cells<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> The study shows that Mebendazole (MBZ) affects gene expression in gastric cancer cells, particularly by altering histone and inflammation genes. It may have epigenetic and immunological effects, which could improve patient prognosis. Further studies are needed to better understand the mechanisms.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>To be continued&#8230;<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> July 1, 2024, Last revised June 10, 2025<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler.png&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-da9592f4\">\n<h2 class=\"wp-block-heading\" id=\"parasitaere-compariso\"><span class=\"ez-toc-section\" id=\"Antiparasitic_drugs_%E2%80%93_compariso\"><\/span>Antiparasitic drugs &#8211; compariso<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Short summary of differences and similarities<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Although several antiparasitic agents are being investigated for their effect against cancer, they work in widely different ways:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mebendazole:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Destroys the cancer cell&#8217;s internal &#8220;skeleton&#8221; (microtubules) to stop cell division. Among the drugs mentioned here, it is the one most extensively studied in clinical trials.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fenbendazole:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Also destroys the cell&#8217;s &#8220;skeleton&#8221; but is additionally believed to create metabolic stress. It has a strong anecdotal history.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Niclosamide:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Interrupts the cell&#8217;s energy supply while simultaneously blocking its growth signals.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ivermectin:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Creates internal stress in the cell and prevents it from pumping out chemotherapy, which can counteract resistance.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hydroxychloroquine:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Blocks the cell&#8217;s &#8220;recycling system&#8221; (autophagy), causing it to succumb to its own waste.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The point is that these different mechanisms allow for strategic combinations where cancer can be attacked from multiple angles simultaneously to achieve a stronger effect.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antiparasitic_agents_compared\"><\/span>Antiparasitic agents compared<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7.png\" alt=\"Niclosamid symboliseret ved rosa forh\u00f8jning af noget celleagtigt. rosa kugleforede elementer omkring denne. bl\u00e5 baggrund \u00f8verst.\" class=\"wp-image-14768\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most promising areas within complementary and experimental cancer treatment is repurposed drugs. A particularly interesting group consists of antiparasitic agents. Many of these substances have proven to possess potent anticancer properties, but it is crucial to understand that they do not all work the same way. Their attacks on cancer cells are widely different.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Below is a comparison of the most discussed substances and their unique mechanisms of action to provide a clear overview of their individual strengths and potential.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mebendazole_Vermox\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/vermox\/\">Mebendazole<\/a> (Vermox)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved celle i rosa, der er sk\u00e5ret op. hvid baggrund.\" class=\"wp-image-14780\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Main mechanism: Destruction of microtubules (the cell&#8217;s scaffolding)<\/li>\n\n\n\n<li>Mebendazole&#8217;s primary and most well-documented effect is a disruption of the cancer cells&#8217; internal skeleton. The substance, which belongs to the benzimidazole family, works by binding to the protein tubulin and preventing it from assembling into microtubules. This effectively stops cell division (mitosis) and leads to cell death. Mebendazole is also the benzimidazole that has been the subject of the most formal clinical investigations, especially in connection with aggressive brain tumors (glioblastoma), where it has been tested as a supplement to standard chemotherapy.<\/li>\n\n\n\n<li><strong>Characteristics:<\/strong> A direct, physical attack on the cell&#8217;s structure. It is the benzimidazole most extensively studied in human clinical trials.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fenbendazole\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/fenbendazol\/\">Fenbendazole<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved Kompliceret celle i bl\u00e5 med lyser\u00f8de enheder indeni. Bl\u00e5 baggrund.\" class=\"wp-image-14781\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism:<\/strong> Destruction of microtubules (the cell&#8217;s scaffolding).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fenbendazole shares the same core mechanism as mebendazole, namely destroying the cancer cells&#8217; microtubules and thereby stopping cell division. Its popularity, however, is driven more by preclinical studies (laboratory and animal trials) as well as strong patient reports and compelling anecdotal evidence.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary mechanisms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In addition to the microtubule effect, research indicates that fenbendazole has a unique ability to stress the metabolism of cancer cells by blocking their sugar uptake. Certain studies also indicate that it can reactivate the tumor-suppressor gene p53.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Characterized by having a strong anecdotal history and a research focus on its ability to create metabolic stress.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Niclosamide\"><\/span><a href=\"\/niclosamid\">Niclosamide<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved lilla celle med nogle orange enheder p\u00e5 overfladen. hvid baggrund.\" class=\"wp-image-14779\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Niclosamide takes a completely different approach, which is primarily metabolic and signal-oriented.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Metabolic collapse (energy blockade)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Niclosamide acts as an &#8220;uncoupler&#8221; in the cancer cell&#8217;s power plants, the mitochondria. It simply short-circuits the process that produces energy (ATP), leading to an immediate and fatal loss of energy in the cell. Simultaneously, massive oxidative stress is created (via ROS production), further damaging the cell.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary, but crucial mechanism: Signaling sabotage<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Beyond the energy blockade, niclosamide&#8217;s great strength is its ability to simultaneously inhibit a wide range of central signaling pathways that cancer cells depend on (Wnt, STAT3, mTOR, NF-\u03baB). This hits not only growth but also the otherwise resilient cancer stem cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A dual attack that both removes the cell&#8217;s fuel and interrupts its internal communication.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ivermectin\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/ivermectin\/\">Ivermectin<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved hudlignende struktur med forh\u00f8jning. der foreg\u00e5r proceller med dna-lignende enheder. lysebl\u00e5 baggrund \u00f8verst.\" class=\"wp-image-14778\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin is again different from those mentioned above, working broadly on several systems related to cell stress and transport.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Induction of oxidative stress and ion imbalance<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Like niclosamide, ivermectin can create high levels of oxidative stress (ROS) that are toxic to the cancer cell. It is also believed to affect ion channels in the cell membrane, disrupting the fragile electrical balance the cell maintains.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary, but crucial mechanism: Inhibition of transport pumps<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>One of the main causes of chemoresistance is that cancer cells develop pumps (such as P-glycoprotein) that actively push chemotherapy back out of the cell. Ivermectin has been shown to block these pumps. This means it can make resistant cancer cells sensitive to chemotherapy again, as the poison now remains inside the cell.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Creates internal stress and prevents the cancer cell from &#8220;pumping&#8221; out toxins.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hydroxychloroquine_Plaquenil\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/plaquenil\/\">Hydroxychloroquine<\/a> <a href=\"https:\/\/jegharkraeft.dk\/plaquenil\/\">(Plaquenil)<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved Rosa celle der er cirkelformet. Andre enheder deri i forskellige rosa nuancer. hvid baggrund.\" class=\"wp-image-14777\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This drug, which is an antimalarial agent, has a very specific and unique mechanism.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Blocking autophagy (the cell&#8217;s recycling station)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Autophagy is a survival mechanism where the cell breaks down and recycles its own damaged parts to obtain energy and building blocks under pressure (e.g., during chemotherapy). Hydroxychloroquine blocks this process. The result is that the cancer cell cannot &#8220;clean up&#8221; after itself, leading to an accumulation of toxic waste inside. This makes the cell significantly more vulnerable and can push it toward cell death, especially when it is already stressed by other treatments.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prevents the cancer cell from &#8220;eating itself&#8221; to survive pressure.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Artemisinin_and_derivatives\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/artemisia\/\">Artemisinin<\/a> (and derivatives)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved en oversk\u00e5ret celle i rosa med en masse funktioner og molekyler og noget der ligner en sav igennem. Hvid baggrund.\" class=\"wp-image-14792\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Iron-activated cell death via free radicals<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Artemisinin, originally a Nobel Prize-winning drug for malaria, has a highly effective and specific mechanism of action. Cancer cells need large amounts of iron to divide rapidly, and they therefore have a much higher concentration of iron than normal, healthy cells. The artemisinin molecule contains a special chemical structure (an endoperoxide bridge) that reacts violently when it comes into contact with iron. This reaction creates an explosion of unstable and highly damaging molecules called free radicals (specifically Reactive Oxygen Species, ROS). This internal &#8220;bomb&#8221; of oxidative stress destroys the cancer cell&#8217;s membranes, proteins, and DNA from within, forcing it into cell death. The process has similarities to a specific type of cell death called ferroptosis (iron-dependent cell death).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Access in Denmark:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The pure, most potent substance artesunate (a derivative) is a prescription drug in Denmark, while the plant <em>Artemisia annua<\/em> is typically sold as a dietary supplement.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Functions as a &#8220;Trojan horse&#8221; that exploits the cancer cell&#8217;s own iron dependency to create a targeted internal explosion.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Resistance_and_safety_during_long-term_use\"><\/span>Resistance and safety during long-term use<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When using repurposed parasitic drugs in an oncological context, critical factors regarding resistance and safety apply to all the mentioned compounds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risk of clinical resistance<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cancer cells are biologically extremely adaptable. While individual clinical observations may suggest a lack of resistance, extensive research documents that cancer cells can develop resistance over time. The most central mechanism is the overexpression of so-called ABC transporters (including P-glycoprotein). These function as molecular pumps that actively remove the drug from the cell&#8217;s interior before it can take effect [1, 4]. Continuous exposure without breaks can create a selection pressure, where only the most resistant cancer cells survive and multiply [2].<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The importance of monitoring<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Because cancer treatment often requires higher doses or longer durations than a standard parasite treatment, continuous monitoring is essential. This is particularly true for benzimidazoles (such as mebendazole), where long-term use is associated with the risk of drug-induced liver toxicity [3]. Monitoring with blood tests, including liver function tests (ALT\/AST), is therefore a necessary safety precaution to ensure that treatment can continue without damaging the organs.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Overview\"><\/span>Overview<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved celle med bl\u00e5 midte. derom m\u00f8rk rosa cirkelform. og udenp\u00e5 denne rosa cirkel med runde elementer i bl\u00e5 tomer. og dette omgives a forskellige symboler p\u00e5 virkninger. hvid baggrund.\" class=\"wp-image-14776\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>Drug<\/strong><\/td><td><strong>Primary Mechanism of Action<\/strong><\/td><td><strong>Unique Characteristics<\/strong><\/td><\/tr><\/thead><tbody><tr><td>Mebendazole<\/td><td>Destruction of microtubules<\/td><td>Attacks the cell&#8217;s &#8220;skeleton.&#8221; Most studied in clinical trials.<\/td><\/tr><tr><td>Fenbendazole<\/td><td>Destruction of microtubules<\/td><td>Attacks the cell&#8217;s &#8220;skeleton.&#8221; Strong anecdotal history.<\/td><\/tr><tr><td>Niclosamide<\/td><td>Metabolic collapse (energy blockade)<\/td><td>Removes cell fuel and sabotages signaling pathways. Poor absorption.<\/td><\/tr><tr><td>Ivermectin<\/td><td>Induction of oxidative stress \/ Inhibition of pumps<\/td><td>Creates internal stress and counteracts chemoresistance.<\/td><\/tr><tr><td>Hydroxychloroquine<\/td><td>Inhibition of autophagy<\/td><td>Prevents the cell&#8217;s &#8220;recycling system&#8221; from working.<\/td><\/tr><tr><td>Artemisinin (and derivatives)<\/td><td>Iron-activated formation of free radicals (ROS)<\/td><td>Exploits high iron content in cancer cells to create oxidative stress.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion-2\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved Planche med celle der bliver angrebet a forskellige enheder. bl\u00e5 baggrund.\" class=\"wp-image-14782\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The clear conclusion is that there is no single &#8220;antiparasitic&#8221; effect against cancer. Each substance represents a unique angle of attack that exploits different vulnerabilities in the cancer cell&#8217;s complex machinery. This diversity opens the door for intelligent combination treatments, where a tumor can be hit from several sides simultaneously. In the long run, a deeper understanding of these mechanisms can lead to more tailored treatment, where the choice of a repurposed drug is based on the specific biochemical profile of the individual tumor. The potential lies not in a single &#8220;miracle cure,&#8221; but in the strategic use of an entire arsenal of different, rediscovered &#8220;keys,&#8221; each of which can unlock a new door in the cancer cell&#8217;s defense.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As these are medications, it is naturally essential to discuss their use with your healthcare provider.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/metabolisk-strategi\/\">Metabolic strategy \u2013 block signaling pathways by cancer type \u2013 chart overviews <\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are in doubt about interaction, it can be checked here: <\/p>\n\n\n\n<p class=\"has-custom-bl-links-color has-text-color has-link-color wp-elements-44e9f8537547201e0b860469b007bb4f wp-block-paragraph\"><a href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\" rel=\"noreferrer noopener\">Drugs.com<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/repurposed-drugs\">Repurposed Drugs<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/ingen-medicin-plan-b\/\">No medicine &#8211; Plan B<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Se ogs\u00e5 <a href=\"https:\/\/jegharkraeft.dk\/parasittens-vej-til-kraeft\/\">The parasite&#8217;s path to cancer<\/a><a href=\"https:\/\/jegharkraeft.dk\/repurposed-drugs\"><\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ivermectin:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7e9f696fce92d4cf7bec886436fdf950 wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315152\" target=\"_blank\" rel=\"noreferrer noopener\">Ivermectin, a potential anticancer drug derived from an antiparasitic agent<\/a> (Science Direct, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This article provides a broad overview of the many proposed anti-cancer mechanisms for ivermectin. It mentions, among other things, the effect on Hippo, Akt\/mTOR, and WNT signaling pathways, which supports the drug&#8217;s versatility.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2b03c9ac0cb4e98b5638f3e5cfaf7565 wp-block-paragraph\"><a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.201404084\" target=\"_blank\" rel=\"noreferrer noopener\">The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer<\/a> (EMBO Molecular Medicine, 2014)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> A very specific study confirming that ivermectin is an effective blocker of the WNT signaling pathway, which is a fundamental and often overactive signaling pathway in many cancers, including colorectal and breast cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0f1586025b6aa979620f414347b29e0f wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40174264\/\" target=\"_blank\" rel=\"noopener\">Targeting EGFR\/PI3K\/AKT\/mTOR and Bax\/Bcl-2\/caspase3 pathways with ivermectin mediates its anticancer effects against urethane-induced non-small cell lung cancer in BALB\/c mice<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> An animal study shows that the drug ivermectin has a strong anti-cancer effect on non-small cell lung cancer (NSCLC). The study concludes that ivermectin works by blocking the central growth signaling pathway (EGFR\/PI3K\/AKT\/mTOR), leading to increased cell death and inhibited tumor growth.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b0958b54bba05afef792e253bf20c0a2 wp-block-paragraph\"><a href=\"https:\/\/williamscancerinstitute.com\/ivermectin-and-cancer-exploring-the-potential-link\/\" target=\"_blank\" rel=\"noopener\">Ivermectin and Cancer: Exploring the Potential Link <\/a>(Williams Cancer Institute, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Ivermectin has potential as a cancer treatment by inhibiting tumor growth, inducing apoptosis, strengthening the immune system, and preventing angiogenesis. These mechanisms may supplement existing therapies, but further clinical research is necessary. Overall, Ivermectin opens new possibilities for the development of innovative cancer treatments.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-f6d7c89947019a91fc6294d2c728a83d wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315152?fbclid=IwY2xjawEWAGNleHRuA2FlbQIxMQABHdZYgWOdPXTAstplSsyjo-mMcyZdAVFA3Rp98ZOYM7HntHyhuuR8focP-Q_aem_0Zm90ecrP8sdxnVd2YUw4Q\" target=\"_blank\" rel=\"noopener\">Ivermectin, a potential anticancer drug derived from an antiparasitic drug<\/a> (Science Direct, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Ivermectin, an antiparasitic macrolide, has shown promising potential as a cancer treatment by inhibiting tumor cell proliferation and promoting apoptosis through multiple signaling pathways. This opens possibilities for clinical use of ivermectin as an anti-neoplastic agent. Further research is needed to realize this potential in cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fenbendazole:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e8ffd92d3c372aa71d43157989c29018 wp-block-paragraph\"><a href=\"https:\/\/www.onedaymd.com\/2025\/04\/fenbendazole-ivermectin-mebendazole-breast-cancer.html?m=1&amp;fbclid=IwY2xjawLLzjlleHRuA2FlbQIxMQBicmlkETB6Z3JmcTBiVjE3aWZsOVk1AR6YqtGVRRh4AKT27Xbrs1D-ZnsZhEUm0JA-kHYlQMSGDKJLlqcqwdjGKleXxA_aem_4liz50FMI2Lok_3mycN_Kw\" target=\"_blank\" rel=\"noopener\">Fenbendazole, Ivermectin and Mebendazole for Breast Cancer Success Stories \u2013 37 Case Reports<\/a> (The Medical Adviser, June 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Several peer-reviewed articles and case studies suggest that Fenbendazole, Ivermectin, and Mebendazole may play an important role in the treatment of stage 4 breast cancer. Research shows that these substances have different anti-cancer mechanisms that can be effective against cancer cells. Specific studies include a protocol for Ivermectin, as well as investigations of Fenbendazole and Mebendazole in relation to breast cancer and metastases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-13e5fb2c69e85ffcba2d5becf9402b57 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40509264\/\" target=\"_blank\" rel=\"noopener\">Fenbendazole Exhibits Antitumor Activity Against Cervical Cancer Through Dual Targeting of Cancer Cells and Cancer Stem Cells: Evidence from In Vitro and In Vivo Models<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Fenbendazole can kill both common cancer cells and the difficult cancer stem cells in cervical cancer by disrupting the cells&#8217; growth cycle. It stopped tumor growth in animal models without weight loss, in contrast to chemotherapy, and resulted in full survival in those treated. These results make fenbendazole a promising treatment choice against cervical cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7ee523fe740ebd3bc0868dae9015338d wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39736624\/\" target=\"_blank\" rel=\"noopener\">Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Fenbendazole can inhibit the growth and promote the death of ovarian cancer cells by disrupting the cell cycle and causing mitotic catastrophe. It was also shown to reduce tumor growth in mice, suggesting it could become a promising treatment for ovarian cancer. These results open possibilities for new therapies against this serious disease.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mebendazole:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0e1e33aab10563d5c30e70d2e19e78b4 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34218593\/\" target=\"_blank\" rel=\"noopener\">Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update <\/a>(PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Albendazole and mebendazole are broad-spectrum deworming medications that block microtubules and have shown promising anti-cancer effects in vitro and in vivo. They can be used against parasitic infections and potentially as cancer treatment, but long-term use can cause side effects like liver damage. Mebendazole is currently more popular in cancer trials due to albendazole&#8217;s toxicity.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-affcbe042ec922ebc83722818f345c15 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39614899\/\" target=\"_blank\" rel=\"noopener\">Synergistic inhibition of proliferation and induction of apoptosis in oral tongue squamous cell carcinoma by mebendazole and paclitaxel via PI3K\/AKT pathway mitigation<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Mebendazole and paclitaxel have a synergistic effect on inhibiting proliferation and microtubular structures in oral tongue squamous cell carcinoma (OTSCC) by inhibiting the PI3K\/AKT signaling pathway. The combination increases apoptosis markers and may be a promising treatment for OTSCC. Further research is needed to confirm their clinical potential.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dd7d2c1cc24e31773969660ad3fc7bb1 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39527027\/\" target=\"_blank\" rel=\"noopener\"><em>In vitro<\/em>&nbsp;evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Mebendazole nanostructures (MBZ-NLCs) are stable and contain a larger portion of the active substance than standard forms. They are ten times more effective against cancer cells and can prevent the movement of cancer cells in laboratory experiments. The results suggest that mebendazole nanostructures could become a good treatment for lung cancer, but more tests in the body are needed.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Plaquenil:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d554516ea4c3ee7a986f5a34bdafc977 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40185322\/\" target=\"_blank\" rel=\"noopener\">The imidazoline I<sub>2<\/sub>&nbsp;receptor agonist 2-BFI enhances cytotoxic activity of hydroxychloroquine by modulating oxidative stress, energy-related metabolism and autophagic influx in human colorectal adenocarcinoma cell lines<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> A new study shows that the substance 2-BFI (an imidazoline I2-receptor agonist) significantly enhances the cell-killing effect of the autophagy inhibitor hydroxychloroquine (HCQ) against colorectal cancer cells. The combination works by creating increased oxidative stress and disrupting cancer cell metabolism and survival mechanisms.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3fde295fa4b3eb3271b0e84bae3f79b4 wp-block-paragraph\"><a href=\"https:\/\/www.upmc.com\/media\/news\/030922-malaria-drug-chemotherapy\" target=\"_blank\" rel=\"noreferrer noopener\">Malaria Drug Could Combat Chemotherapy-Resistant Head and Neck Cancers<\/a> (UPMC, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance: <\/strong>This is an easy-to-understand summary of a study that shows a concrete example of how hydroxychloroquine is used to overcome chemo-resistance. It explains how the substance can &#8220;re-sensitize&#8221; cancer cells so that chemotherapy works again.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-47152620ee02d49434ca011b60f5f8fc wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5718030\/\" target=\"_blank\" rel=\"noopener\">Repurposing Drugs in Oncology (ReDO)\u2014chloroquine and hydroxychloroquine as anti-cancer agents <\/a>(PubMed, 2017)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Chloroquine (CQ) and hydroxychloroquine (HCQ) have potential as anti-cancer treatment, especially in combination with standard therapies. They affect both cancer cells and the tumor microenvironment through autophagy inhibition and modulation of signaling pathways such as p53 and CXCR4-CXCL12. Further clinical studies are necessary to optimize dosing and treatment regimens.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Niclosamide:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-67a4902e9e2dd083baa0cf254855860e wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40446543\/\" target=\"_blank\" rel=\"noopener\">Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1\/TTK signaling pathway and structural insights in the NCI-60<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This study identified 35 genes, including CDK1 and TTK, as important targets in ovarian cancer, which often develops resistance to treatment. NSC765690 (MCC22) was found to be a promising niclosamide analog with strong activity against both targets, which may help overcome chemotherapy resistance. The results show a data-driven approach to developing new therapies for ovarian cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-342d3eca819bc491552472a375c47e44 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40521512\/\" target=\"_blank\" rel=\"noopener\">Niclosamide Treatment Suppressed Metastatic, Apoptotic, and Proliferative Characteristics of MDA-MB-231 Cancer Stem Cells<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This study showed that niclosamide effectively induces apoptosis and stops the cell cycle in aggressive triple-negative breast cancer-CSCs in a 3D model. The treatment reduced metastasis- and resistance-related genes as well as EMT markers, which may improve treatment effectiveness against cancer. The results suggest that niclosamide can increase CSC sensitivity and prevent tumor recurrence.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4def919f735299993d08bb6a73814c2c wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40153934\/\" target=\"_blank\" rel=\"noopener\">Pharmacological advances and therapeutic applications of niclosamide in cancer and other diseases<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Niclosamide is an FDA-approved drug with potential in cancer treatment, especially against resistant ovarian cancer, by modulating cell proliferation and apoptosis. New formulations and nanotechnology improve bioavailability, strengthening its therapeutic possibilities. It shows promising versatility in the treatment of cancer, viral infection, and inflammatory diseases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7ae98a01281a9f617c318c7a12f8a6a5 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40466616\/\" target=\"_blank\" rel=\"noopener\">Study on the mechanism of niclosamide ethanolamine salt-hydroxypropyl-\u03b2-cyclodextrin in the treatment of colon cancer based on metabolomics and 16S rRNA technology<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> NHC, an improved form of niclosamide, shows increased solubility and potential as a treatment for colon cancer. The analysis confirms that NHC is more effective than NES, and metabolomics as well as 16S rRNA investigate its mechanism. This may open new possibilities for niclosamide-based cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-28451a47f3f0c384dbad5b7c5805b9ae wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38820079\/\" target=\"_blank\" rel=\"noopener\">Antitumor activity of niclosamide-mediated oxidative stress against acute lymphoblastic leukemia<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Niclosamide was shown to be able to inhibit growth and induce apoptosis in acute lymphoblastic leukemia (ALL) by increasing reactive oxygen species and activating TP53. It has potential as a new treatment to improve response and extend survival in ALL patients. These results indicate that niclosamide could become a promising therapeutic agent against ALL.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>In General:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4d441217b21e505edf15434d60035b2b wp-block-paragraph\"><a href=\"https:\/\/isom.ca\/wp-content\/uploads\/2024\/09\/Targeting-the-Mitochondrial-Stem-Cell-Connection-in-Cancer-Treatment-JOM-39.3.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Targeting the Mitochondrial-Stem Cell Connection in Cancer<\/a> <a href=\"https:\/\/isom.ca\/wp-content\/uploads\/2024\/09\/Targeting-the-Mitochondrial-Stem-Cell-Connection-in-Cancer-Treatment-JOM-39.3.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Treatment: A Hybrid Orthomolecular Protocol<\/a> (Journal of Orthomolecular Medicine)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-cc085c5155dfa1316a96e7e54c08dd01 wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noopener\">Interactions (search for preparations) <\/a>(Interaktionsdatabasen, Danish Medicines Agency)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Resistens og monitorering<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc50e57b1dcd262340691d7522606ebb wp-block-paragraph\">[1]&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S136876462500113X\" target=\"_blank\" rel=\"noreferrer noopener\">The emerging roles of ATP-binding cassette transporters in cancer multidrug resistance<\/a>&nbsp;(ScienceDirect, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A fully updated review of how ABC transporters function as pumps that create resistance in cancer cells. The article describes the challenges of overcoming this mechanism to ensure effective drug delivery.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1b60c85aac181848ef6d7bd45bcb2f98 wp-block-paragraph\">[2]&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4096024\/\" target=\"_blank\" rel=\"noreferrer noopener\">Repurposing Drugs in Oncology (ReDO)\u2014A project to find new uses for old drugs<\/a>&nbsp;(ecancer, 2014)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A comprehensive article series reviewing the need for monitoring and the theoretical risks of resistance when moving drugs from short-term use to long-term cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-9abe0ae75071ee5e759625425fcaccf9 wp-block-paragraph\">[3]&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34218593\/\" target=\"_blank\" rel=\"noreferrer noopener\">Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update<\/a>&nbsp;(PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article based on a review of benzimidazoles (mebendazole and albendazole). It describes their anti-cancer effects but explicitly states that long-term use can cause side effects such as liver damage.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-669070973af0f414a0297a370aada789 wp-block-paragraph\">[4]&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29643473\/\" target=\"_blank\" rel=\"noreferrer noopener\">Revisiting the role of ABC transporters in multidrug-resistant cancer<\/a>&nbsp;(PubMed, 2018)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A scientific article documenting how the overexpression of ABC transporters (especially P-glycoprotein) in cancer cells is a major cause of multidrug resistance. The study demonstrates that these pumps effectively remove drugs from cells, thereby blocking their efficacy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> July 1, 2024, Last revised July 28, 2026<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Treatments\" >Treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Complementary_and_Alternative_Treatments\" >Complementary and Alternative Treatments<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Mebendazole_%E2%80%93_Vermox_and_cancer\" >Mebendazole &#8211; Vermox and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#What_are_Vermox_and_Mebendazole\" >What are Vermox and Mebendazole<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Important_about_absorption\" >Important about absorption<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#The_difference\" >The difference<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Parasites_vs_cancer_%E2%80%93_similarities\" >Parasites vs. cancer &#8211; similarities<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Advantages_as_off-label\" >Advantages as off-label<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Side_effects\" >Side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Antiparasitic_agents\" >Antiparasitic agents<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Fat-rich_foods_with_a_high_content_of_healthy_fat\" >Fat-rich foods with a high content of healthy fat<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Antiparasitic_drugs_%E2%80%93_compariso\" >Antiparasitic drugs &#8211; compariso<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Antiparasitic_agents_compared\" >Antiparasitic agents compared<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Mebendazole_Vermox\" >Mebendazole (Vermox)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Fenbendazole\" >Fenbendazole<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Niclosamide\" >Niclosamide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Ivermectin\" >Ivermectin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Hydroxychloroquine_Plaquenil\" >Hydroxychloroquine (Plaquenil)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Artemisinin_and_derivatives\" >Artemisinin (and derivatives)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Resistance_and_safety_during_long-term_use\" >Resistance and safety during long-term use<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Overview\" >Overview<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/#Conclusion-2\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatments Complementary and Alternative Treatments Mebendazole &#8211; Vermox and cancer Content: What are Vermox and Mebendazole Vermox is a brand name for the drug mebendazole, which is an antiparasitic agent. It is used to treat infections caused by various types of worms, including tapeworms and roundworms. Mebendazole works by preventing the worms&#8217; ability to absorb [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":33034,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[393,375,374,395],"tags":[],"class_list":["post-33036","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-repurposed-drugs","category-alternative-treatments","category-treatments","category-miscellaneous-and-experimental-agents"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33036","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=33036"}],"version-history":[{"count":4,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33036\/revisions"}],"predecessor-version":[{"id":39974,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33036\/revisions\/39974"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/33034"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=33036"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=33036"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=33036"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}