{"id":33007,"date":"2025-12-12T16:11:54","date_gmt":"2025-12-12T15:11:54","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=33007"},"modified":"2026-06-06T10:17:52","modified_gmt":"2026-06-06T09:17:52","slug":"ivermectin","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/ivermectin\/","title":{"rendered":"Ivermectin and cancer. Ivermectin cancer. Repurposed drugs. Cancer stem cells (CSC). The WNT signaling pathway. Chemoresistance. Metabolic cancer treatment. P-glycoprotein. Triple-negative breast cancer (TNBC). Non-small cell lung cancer (NSCLC). Colorectal cancer."},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-ef5a4dbc8253991a40963ca62b3bf46f has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-85c9ab605a9af581478ba1bfba8fd611\"><span class=\"ez-toc-section\" id=\"Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatments-overview\/\">Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-52532d4beacf4a32227a79286a8276fc\"><span class=\"ez-toc-section\" id=\"Complementary_and_Alternative_Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/alternative-cancer-treatments-overview\/\">Complementary and Alternative Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-c482b7d19e6255d7176b8a98ad12b176 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-3f4534b34430eaa870f1cf5f5113d9eb\"><a href=\"https:\/\/jegharkraeft.dk\/akupunktur\/\">Physical treatments<\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-34eaa08c272eb95c6ec142be27e82dde\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Repurposed Drugs &#8211; General<\/mark><\/a>\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-780fac237d6d09f0087842050420bfba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/aspirin\/\">Painkillers and anti-inflammatory drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-fad7d0169f73487a5cb08247fb6344df\"><a href=\"https:\/\/jegharkraeft.dk\/en\/dipyridamole\/\">Heart and circulatory medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-b7dcac9665837fadafc37a7b04b61f06\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Antibiotics and antiparasitic agents<\/mark><\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-e87df1a7a6119779a4006c75b78b460e\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\">Doxycycline<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-5311555f3d0b0aeaed276a15e6d41095\"><a href=\"https:\/\/jegharkraeft.dk\/en\/fenbendazole\/\">Fenbendazole<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-cb2037df4285a63d184d69e47b9b46f7\"><a href=\"#ivermectin\">Ivermectin (scroll down)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/\">Mebendazole<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/niclosamide\/\">Niclosamide<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/plaquenil\/\">Plaquenil<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/mebendazole\/\">Vermox<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a99575c8ffb4e827783ab6d56f16ed45\"><a href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/\">Diabetes medication<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6c31e64b006d888e2e94cb9770a3c32c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/low-dose-naltrexone\/\">Agents affecting hormones and signaling substances<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-dd7ca0bc23a9ec3ca6e860ef8de7693a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/\">Other medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-66a0e4204f5201bcc8494f5822b38efe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/the-coc-protocol\/\">COC Protocol<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9504e56e950d068c15963cbdbf1fdaaf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b\/\">No medication \u2013 Plan B<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50bb8d7b4bb216418ba3c0d4a402648c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-chemotherapy\/\">Repurposed drugs and chemotherapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-af88e7f595afd58f141d2c174a141555\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/\">Repurposed drugs and radiation therapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7098df34ebce445cd1790d85e10991eb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/flcccs-ranking\/\">FLCCC\u2019s ranking of repurposed drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c827eb85783b3d07583409effc04d57\"><a href=\"https:\/\/jegharkraeft.dk\/en\/brain-metastases-and-bloodbrain-barrier\/\">Brain metastases and the blood-brain barrier<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-cf6cfac91ed1b7d193bc5d25a711b818\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bombs-fire-extinguishers-and-timing\/\">Bombs, fire extinguishers, and timing<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img decoding=\"async\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin8.jpg\" alt=\"Ivermectin symboliseret ved en blisterpakke med p\u00e5skriften Ivermectin 12 mg. holdt op mellem to fingre. Hylder med piller i baggrunden.\" class=\"wp-image-32997\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\"\/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin8.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-906497af\">\n<h1 id=\"ivermectin\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ivermectin_and_cancer\"><\/span>Ivermectin and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Content:<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Ivermectin_and_cancer\">Ivermectin and cancer<\/a> (scroll down)<\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Antiparasitic_drugs_%E2%80%93_compariso\">Antiparasitic agents compared<\/a> (scroll to)<\/li>\n<\/ol>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Summary of Ivermectin<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Strategic purpose:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>To function as the &#8220;broad hammer&#8221; that hits the cancer&#8217;s root system (stem cells) and stops spreading. Ivermectin is used to capture cell populations that normally escape chemo and radiation and are responsible for relapse.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mechanisms:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Ivermectin is unique because it works on many fronts simultaneously. It shuts down the signals that cause cancer to grow (WNT and PAK-1), prevents the cell from pumping out toxins (P-glycoprotein), and makes the tumor visible to the immune system.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Role in treatment:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Acts as the central focal point that binds the entire treatment together in a metabolic strategy. It significantly enhances the effect of other medications (such as chemo or hormone therapy) and prevents recurrence by keeping stem cells in check.<\/li>\n<\/ul>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h2 id=\"ivermectin\" class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ivermectin_in_a_cancer_strategy\"><\/span>Ivermectin in a cancer strategy<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2.jpg\" alt=\"Ivermectin symboliseret ved nogle bl\u00e5-turkise celler\" class=\"wp-image-26174\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin2-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin (brand names such as Stromectol and Scabior) is originally known as an antiparasitic agent that has saved millions from river blindness. However, in modern integrative oncology, the substance has achieved status as one of the most potent &#8220;multitarget&#8221; drugs we know.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For the cancer patient, Ivermectin is interesting for one primary reason:<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">It breaks resistance<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Standard treatment (chemotherapy and radiation) often fails over time because cancer cells learn to defend themselves. They mutate, they hide, and they pump the poison back out. Ivermectin intervenes and sabotages precisely these defensive works.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Where an agent like Plaquenil has one primary function (to stop the cleanup), Ivermectin functions as a Swiss army knife. It attacks the cancer cell from the surface, deep into the core to the stem cells, and even changes the way the immune system perceives the tumor. It is therefore an indispensable piece for patients fighting aggressive, metastatic cancer where the &#8220;standard package&#8221; is no longer sufficient.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/living-with-chronic-cancer\/\">Living with incurable cancer<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Tip_for_absorption\"><\/span>Tip for absorption<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"has-custom-menu-links-background-color has-background wp-block-paragraph\"><strong>Ivermectin is lipophilic (fat-loving). Studies show that its absorption into the bloodstream increases significantly (up to 2.5 times) if it is taken with a high-fat meal rather than on an empty stomach.<br>See the overview of fat-rich foods at the bottom of the section.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Attack_on_cancer_stem_cells\"><\/span>Attack on cancer stem cells<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13.jpg\" alt=\"Ivermectin symboliseret ved nogle runde brikker, der har streger ind til en midtercelle. Nogle r\u00f8de celler ligger ved siden af denne.\" class=\"wp-image-26172\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin13-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This is Ivermectin&#8217;s most important property and the primary reason it is used preventatively against recurrence. The problem with traditional cancer treatment is that it primarily kills cells that divide rapidly.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">But in any tumor, there is a small group of cells\u2014cancer stem cells (CSC)\u2014that divide slowly or not at all. They function as &#8220;queens in the beehive.&#8221; Chemotherapy bounces off them because they are dormant. When the treatment is over, they wake up and create new tumors (metastases).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cancer stem cells depend on some very specific &#8220;embryonic&#8221; signaling pathways to maintain their ability to survive\u2014signals that the body normally only uses when a fetus is being formed. The most important ones are called WNT\/Beta-catenin, Hedgehog, and Notch.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-signaling-pathways\/\">Block cancer signaling pathways<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Ivermectin&#8217;s effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin has proven to be a powerful inhibitor of, in particular, the WNT signaling pathway. By blocking this signal, the stem cells lose their &#8220;instruction manual.&#8221; They lose the ability to renew themselves (self-renewal) and the ability to create new colonies. One thus attacks the disease&#8217;s very ability to reappear. Without Ivermectin (or similar substances), the root is effectively left in the ground. [6, 11]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Stop_the_invasion\"><\/span>Stop the invasion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12.jpg\" alt=\"Ivermectin symboliseret ved nogle lysende linjer mod en lilla celle.\" class=\"wp-image-26171\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin12-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A less known but vital mechanism is Ivermectin&#8217;s ability to block the enzyme PAK-1 (p21-activated kinase 1).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For a cancer cell to spread from, for example, the breast to the bones, it must be able to change shape and move through the tissue. PAK-1 functions as the cell&#8217;s &#8220;motor&#8221; in this process. It is a key enzyme that controls the cell&#8217;s skeleton and its ability to invade new tissue. Over 70% of all cancers (including breast, lung, and pancreatic cancer) have overactive PAK-1, which drives aggressive growth.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Ivermectin&#8217;s effect<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin inhibits PAK-1 effectively. Without this enzyme, the cancer cell becomes &#8220;paralyzed.&#8221; It loses the ability to move and invade surrounding tissue, which significantly reduces the risk of metastases markantly. [2]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Blocking_resistance\"><\/span>Blocking resistance<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10.jpg\" alt=\"Ivermectin symboliseret ved en flade af lilla r\u00f8rformede celler og nogle orange foran disse. Bl\u00e5 enheder tr\u00e6nger gennem de orange celler.\" class=\"wp-image-26169\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin10-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This point can be the difference between whether your other medicine works or not. One of the main reasons cancer treatment fails is that cancer cells develop Multi-Drug Resistance (MDR).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Specifically, the cancer cell forms many small pumps in the cell membrane called P-glycoprotein (P-gp). These pumps function like a bilge pump on a boat. That is, as soon as chemotherapy or other drugs enter the cell, P-gp physically pumps them out again before they can do damage. This is why a tumor can shrink initially, only to suddenly grow again despite treatment.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ivermectins_effect\"><\/span>Ivermectin&#8217;s effect<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin physically binds to these pumps and blocks them completely.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Consequence:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>When the &#8220;bilge pump&#8221; is stopped, the level of medication inside the cancer cell rises sharply. This means that a dose of chemotherapy or other medicine that was previously ineffective suddenly becomes lethal to the cancer cell. Ivermectin &#8220;locks the door&#8221; so the poison stays inside. [4]<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">There are certain chemo agents where the use of Ivermectin can be decidedly dangerous. See the section Safety and Precautions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Immune_effect\"><\/span>Immune effect<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9.jpg\" alt=\"Ivermectin symboliseret ved en bl\u00e5lig side med celler til venstre og en r\u00f8dlig til h\u00f8jre.\" class=\"wp-image-26168\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin9-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Many aggressive tumors are &#8220;cold.&#8221; This means they have built a microenvironment that makes them invisible to the body&#8217;s killer cells (T-cells). For the patient, this is fatal as the immune system stands passively on the sidelines.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin has the ability to induce a special form of cell death called Immunogenic Cell Death (ICD). When a cancer cell dies from Ivermectin, it doesn&#8217;t just quietly implode. It releases danger signals (the molecules ATP and HMGB1) to the surroundings.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This is equivalent to sending up a distress flare from the cancer tissue. It attracts the immune system&#8217;s cells, which suddenly can &#8220;see&#8221; the tumor and begin to attack it. In this way, Ivermectin helps convert a cold tumor into a &#8220;hot&#8221; tumor, which is crucial for long-term survival. [3]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Synergy_with_other_agents\"><\/span>Synergy with other agents<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7.jpg\" alt=\"Ivermectin symboliseret ved forskellige farver og former der bombarderer en r\u00f8d tumor i midten. Tekster i gylden farve. Bl\u00e5 baggrund.\" class=\"wp-image-26166\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin7-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">In a metabolic strategy, Ivermectin never stands alone. Its ability to block pumps and signaling pathways makes it the perfect &#8220;partner&#8221; for other substances in a combination treatment.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Synergi with <a href=\"https:\/\/jegharkraeft.dk\/en\/plaquenil\/\">Plaquenil<\/a><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">This is a classic &#8220;hammer and anvil&#8221; combination. Ivermectin damages the cancer cell (via ICD and microtubule stress). Normally, the cell would attempt to repair the damage by eating itself (autophagy). But if one simultaneously takes Plaquenil, autophagy is blocked. The cell is attacked (by Ivermectin) and deprived of the possibility of repair (by Plaquenil). This leads to metabolic collapse. [5]<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Synergi with <a href=\"https:\/\/jegharkraeft.dk\/hormonterapi-1-2\/\">hormone therapy<\/a> (<a href=\"https:\/\/jegharkraeft.dk\/tamoxifen-1\/\">Tamoxifen<\/a>\/ <a href=\"https:\/\/jegharkraeft.dk\/letrozol\/\">Letrozol<\/a>)<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">In breast cancer, many develop resistance to anti-estrogen treatment over time. Ivermectin can restore sensitivity by downregulating the signaling pathway STAT3, which is often the cause of resistance. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This makes the hormone treatment effective again and thus extends its lifespan. [1]<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Synergi with <a href=\"https:\/\/jegharkraeft.dk\/en\/fenbendazole\/\">Fenbendazol<\/a><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Both Ivermectin and Fenbendazole\/Mebendazole attack the cancer cell&#8217;s structure, but in different ways. Fenbendazole\/Mebendazole hit the microtubules (the skeleton) very specifically, while Ivermectin hits the signals and the pumps. Together, they create massive stress that is difficult for the cell to adapt to.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Safety_and_precautions\"><\/span>Safety and precautions<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6.jpg\" alt=\"Ivermectin symboliseret ved et s\u00e6t h\u00e6nder der holder en tekst frem.\" class=\"wp-image-26165\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin6-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Although Ivermectin has been given in billions of doses against parasites with few side effects, cancer treatment often requires higher doses over longer periods. This requires respect for the substance.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Blood-brain barrier (MDR1 gene)<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin should work in the body but be kept out of the brain. This normally happens automatically via a barrier. However, some people have a genetic variation in the MDR1 gene that makes the barrier leaky. If Ivermectin enters the brain, it can cause neurological symptoms such as dizziness, balance problems, and in rare cases, seizures. Always start low to test your tolerance.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Interactions<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin can increase the effect of blood-thinning medication (such as Warfarin\/ Marevan). This should be closely monitored. Since Ivermectin affects the liver, one should be cautious with alcohol and other liver-straining substances at the same time.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Warning\"><\/span>Warning<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Critical interaction with chemotherapy:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Because Ivermectin blocks P-glycoprotein (the &#8220;bilge pump&#8221;), it can violently increase the concentration of certain types of chemotherapy\u2014such as Etoposide and Taxanes\u2014in the blood. If the body is prevented from excreting the chemo, it can lead to an unintended overdose that can destroy bone marrow and cause life-threateningly low blood counts. If you are in active chemo treatment, the use of Ivermectin requires extreme caution.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-402e73a8130137fa1babcc77017506e4 wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noopener\">Interactions<\/a> (search for preparations) (Interaktionsdatabasen, Danish Medicines Agency) [10]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Research\"><\/span>Research<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5.jpg\" alt=\"Ivermectin symboliseret ved et mikroskop, en blok med ivermectin skrevet \u00f8verst, nogle petrisk\u00e5le, en behandsket h\u00e5nd der drypper v\u00e6ske i sk\u00e5lene.\" class=\"wp-image-26164\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin5-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<h4 class=\"wp-block-heading\">Breast cancer<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Extensive data, including case reports, indicates effectiveness against metastatic breast cancer. Particularly triple-negative breast cancer (TNBC), which is difficult to treat, shows sensitivity to Ivermectin because this form of cancer is highly dependent on the WNT signaling pathway and PAK-1 to grow. [1]<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Lung cancer<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">A new study from 2025 in animal models shows that Ivermectin can effectively slow the growth of non-small cell lung cancer (NSCLC). The study concludes that Ivermectin works by blocking the central growth signaling pathway EGFR\/PI3K\/AKT, leading to increased cell death. [7]<\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Colorectal cancer<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Over 90% of all cases of colorectal cancer are driven by mutations in the WNT signaling pathway. Since Ivermectin is a specific WNT inhibitor, it is theoretically one of the most promising agents for this specific cancer type. [6]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4.jpg\" alt=\"Ivermectin symboliseret ved et ark der holdes op. En pen der ligger ved siden af.\" class=\"wp-image-26163\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/12\/Ivermectin4-768x768.jpg 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">For the cancer patient seeking ways outside the system&#8217;s standard offerings\u2014or where standard offerings are exhausted\u2014Ivermectin represents a strategically important option. It is not merely a &#8220;pill against parasites.&#8221;<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It is one of the few agents capable of hitting the cancer&#8217;s &#8220;root system&#8221; (stem cells) and simultaneously breaking the resistance that makes chemotherapy ineffective. By blocking the WNT signaling pathway, stopping the cell&#8217;s pumps, and making the tumor visible to the immune system, Ivermectin tips the balance in favor of the patient. In a metabolic cocktail, Ivermectin is often the factor that makes the difference between stagnation and regression of the disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fat-rich_foods_with_a_high_content_of_healthy_fat\"><\/span>Fat-rich foods with a high content of healthy fat<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Here is an overview of how you can easily reach either 20 grams or 40 grams of fat through common food items. The specified amounts are approximate, as the exact content may vary slightly depending on the product.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Nuts and almonds<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Nuts have a very high content of unsaturated fat and are one of the easiest ways to increase fat intake without having to eat large quantities.<br><strong>To get 20 g of fat:<\/strong> Eat a small handful (approx. 35 grams) of almonds or walnuts.<br><strong>To get 40 g of fat:<\/strong> Eat two small handfuls (approx. 70 grams) of almonds or walnuts.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Plant oils<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cooking oil such as olive oil or rapeseed oil is pure fat, which makes it highly effective for enriching meals.<br><strong>To get 20 g of fat:<\/strong> Use 1.5 tablespoons (approx. 22 milliliters) of oil in cooking or as a dressing.<br><strong>To get 40 g of fat:<\/strong> Use 3 tablespoons (approx. 44 milliliters) of oil distributed over the day&#8217;s meals.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Avocado<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Avocado contains large amounts of healthy, monounsaturated fat.<br><strong>To get 20 g of fat:<\/strong> Eat 1 large avocado (or 1.5 smaller avocados).<br><strong>To get 40 g of fat:<\/strong> Eat 2 large avocados.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Peanut butter and other nut milks or butters<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Peanut butter is dense in both calories and fat, and it works well on bread or in smoothies.<br><strong>To get 20 g of fat:<\/strong> Eat 1.5 tablespoons (approx. 40 grams) of peanut butter.<br><strong>To get 40 g of fat:<\/strong> Eat 3 tablespoons (approx. 80 grams) of peanut butter.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Dairy products and cheese<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Dairy products and hard cheeses are concentrated sources of fat, which makes them particularly effective for increasing fat intake.<br><strong>To get 20 g of fat:<\/strong> Eat 1.5 deciliters of Greek yogurt (10% fat), 125 grams of cr\u00e8me fra\u00eeche (18% fat), 60 grams of hard cheese (e.g., Danbo 45+ or matured cheddar), or consume 0.6 deciliters of whipping cream (38% fat).<br><strong>To get 40 g of fat:<\/strong> Eat 3 deciliters of Greek yogurt (10% fat), 250 grams of cr\u00e8me fra\u00eeche (18% fat), 120 grams of hard cheese (e.g., Danbo 45+ or matured cheddar), or consume 1.2 deciliters of whipping cream (38% fat).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fatty fish<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Fish such as salmon, mackerel, and herring contribute important omega-3 fatty acids in addition to fat.<br><strong>To get 20 g of fat:<\/strong> Eat about 130 grams of oven-baked salmon or a small can of mackerel in tomato sauce.<br><strong>To get 40 g of fat:<\/strong> Eat a large salmon fillet of about 250 grams.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are in doubt, it can be checked here:<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"has-custom-bl-links-color has-text-color has-link-color wp-elements-44e9f8537547201e0b860469b007bb4f wp-block-paragraph\"><a href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\" rel=\"noreferrer noopener\">Drugs.com<\/a><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noopener\">Interactions (search for preparations) <\/a>(Interaktionsdatabasen, Danish Medicines Agency) <\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d89e37fd7970def906e0c48f5294fed1 wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/ivermectin-immuntoksisk-forskning\/\">Ivermectin&#8217;s immunotoxic effect<\/a> <\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/metabolic-strategi\/\">Metabolic strategy \u2013 block signaling pathways by cancer type \u2013 chart overviews <\/a><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/parasittens-vej-til-kraeft\/\">The parasite&#8217;s path to cancer<\/a> <\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">Repurposed Drugs<\/a> <\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/metabolisk-protokol-forskning\/\">Cancer treatment based on the Mitochondrial Stem Cell Connection<\/a> <\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b-2\/\">No medicine &#8211; Plan B<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>To be continued&#8230;<\/strong><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-fd251cb6c1906cce885f6dbae7ee00cd wp-block-paragraph\">[1] <a href=\"https:\/\/www.cityofhope.org\/stories-of-hope\/triple-negative-drug-combo\" target=\"_blank\" rel=\"noopener\">Novel Drug Combo Shows Promise Against Triple-Negative Breast Cancer<\/a> (City of Hope, 2021) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> An article from a recognized cancer research center describing research into Ivermectin. It confirms that the substance shows promising results against aggressive Triple-Negative breast cancer by attacking the cancer cells in a new way.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0f078290c6fe34fce61397b63d2ac494 wp-block-paragraph\">[2] <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315152\" target=\"_blank\" rel=\"noopener\">Ivermectin, a potential anticancer drug derived from an antiparasitic agent<\/a> (Science Direct, 2021) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> A broad overview of the many anti-cancer mechanisms for Ivermectin. The article reviews the effect on signaling pathways such as Hippo, Akt\/mTOR, and WNT, as well as the stabilization of microtubules.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-da75fc6911f8fde7189b2a62ae7430b2 wp-block-paragraph\">[3] <a href=\"https:\/\/williamscancerinstitute.com\/ivermectin-and-cancer-exploring-the-potential-link\/\" target=\"_blank\" rel=\"noopener\">Ivermectin And Cancer: Exploring The Potential Link<\/a> (Williams Cancer Institute, 2023) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content: <\/strong>A review from an institute working with intratumoral treatments, describing Ivermectin&#8217;s ability to create &#8220;hot&#8221; tumors via immunogenic cell death (ICD).<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2c758a929527e2bebc7d9c19b5fcd1e2 wp-block-paragraph\">[4] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31215501\/\" target=\"_blank\" rel=\"noopener\">Ivermectin reverses the drug resistance in cancer cells <\/a>(PubMed, 2019) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> A key study for understanding Ivermectin as supportive treatment. It documents the substance&#8217;s ability to block the P-glycoprotein pump, which prevents cancer cells from spitting chemotherapy and other medication back out.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d6884109ff6dba3ee2216cbe944fa47f wp-block-paragraph\">[5] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31755894\/\" target=\"_blank\" rel=\"noopener\">Ivermectin induces autophagy-mediated cell death<\/a> (Bioscience Reports\/PubMed, 2019) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> Research showing how Ivermectin not only slows growth but can actively induce cell death and autophagy. This makes it ideal to combine with an autophagy inhibitor like Plaquenil for maximum stress on the cancer cell.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-79dde88f4723acfbf51a023cddbfc647 wp-block-paragraph\">[6] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25143352\/\" target=\"_blank\" rel=\"noopener\">The river blindness drug Ivermectin inhibits WNT-TCF pathway responses<\/a> (EMBO Molecular Medicine, 2014) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> A fundamental study confirming that Ivermectin blocks the WNT signaling pathway. Since WNT is a main driver in colorectal and breast cancer, among others, this study is central to the substance&#8217;s use against cancer stem cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dc08923c0089c70adee1e717bb9ca0a9 wp-block-paragraph\">[7] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40174264\/\" target=\"_blank\" rel=\"noopener\">Targeting EGFR\/PI3K\/AKT\/mTOR and Bax\/Bcl-2\/caspase3 pathways with ivermectin<\/a> (PubMed\/ScienceDirect, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> An animal study showing strong effect against non-small cell lung cancer (NSCLC). The study concludes that Ivermectin works by blocking the central growth signaling pathway EGFR\/PI3K\/AKT, leading to increased cell death and inhibited tumor growth.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-caac59a18d1c175b2fd653f20f050041 wp-block-paragraph\">[8] <a href=\"Ivermectin: Uses, Dosage, Side Effects, Warnings\">Ivermectin: Uses, Dosage, Side Effects, Warnings<\/a> (Drugs.com, 2025) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> Detailed and updated information on side effects, dosages, and contraindications. An important source for checking the safety profile and interactions before starting.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-eb40d36fe308694ef57d9f008324e03c wp-block-paragraph\">[9] <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34218593\/\" target=\"_blank\" rel=\"noopener\">Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents<\/a> (PubMed, 2021) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> A comprehensive review containing important comparative data on the mechanisms of action for the entire group of antiparasitic agents in oncology. The article explains how these substances (just like Ivermectin) work by blocking the cell&#8217;s skeleton (microtubules) and inhibiting glucose uptake.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d332f8c2b9010da46c66886dfb14f5f4 wp-block-paragraph\">[10] <a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noreferrer noopener\">Interaktioner<\/a> (search for preparations) (Interaktionsdatabasen, Danish Medicines Agency)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> Official Danish database for checking medication combinations.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-5460f9782b70f2a7b3a8d907914b0737 wp-block-paragraph\">[11] <a href=\"https:\/\/isom.ca\/article\/targeting-the-mitochondrial-stem-cell-connection-in-cancer-treatment-a-hybrid-orthomolecular-protocol\/\" target=\"_blank\" rel=\"noopener\">Targeting the Mitochondrial-Stem Cell Connection in Cancer Treatment: A Hybrid Orthomolecular Protocol<\/a> (Journal of Orthomolecular Medicine, 2024) <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Content:<\/strong> The article introduces a &#8220;hybrid protocol&#8221; combining repurposed drugs and supplements. The purpose is specifically to hit cancer stem cells by cutting off their energy supply in the mitochondria, supporting the metabolic approach where Ivermectin is a central piece.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> December 12, 2025 <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>To be continued&#8230;<\/strong><\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler.png&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-da9592f4\">\n<h2 class=\"wp-block-heading\" id=\"parasitaere-compariso\"><span class=\"ez-toc-section\" id=\"Antiparasitic_drugs_%E2%80%93_compariso\"><\/span>Antiparasitic drugs &#8211; compariso<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Short summary of differences and similarities<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Although several antiparasitic agents are being investigated for their effect against cancer, they work in widely different ways:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mebendazole:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Destroys the cancer cell&#8217;s internal &#8220;skeleton&#8221; (microtubules) to stop cell division. Among the drugs mentioned here, it is the one most extensively studied in clinical trials.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fenbendazole:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Also destroys the cell&#8217;s &#8220;skeleton&#8221; but is additionally believed to create metabolic stress. It has a strong anecdotal history.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Niclosamide:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Interrupts the cell&#8217;s energy supply while simultaneously blocking its growth signals.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ivermectin:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Creates internal stress in the cell and prevents it from pumping out chemotherapy, which can counteract resistance.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hydroxychloroquine:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Blocks the cell&#8217;s &#8220;recycling system&#8221; (autophagy), causing it to succumb to its own waste.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">The point is that these different mechanisms allow for strategic combinations where cancer can be attacked from multiple angles simultaneously to achieve a stronger effect.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Antiparasitic_agents_compared\"><\/span>Antiparasitic agents compared<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7.png\" alt=\"Niclosamid symboliseret ved rosa forh\u00f8jning af noget celleagtigt. rosa kugleforede elementer omkring denne. bl\u00e5 baggrund \u00f8verst.\" class=\"wp-image-14768\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid7-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">One of the most promising areas within complementary and experimental cancer treatment is repurposed drugs. A particularly interesting group consists of antiparasitic agents. Many of these substances have proven to possess potent anticancer properties, but it is crucial to understand that they do not all work the same way. Their attacks on cancer cells are widely different.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Below is a comparison of the most discussed substances and their unique mechanisms of action to provide a clear overview of their individual strengths and potential.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Mebendazole_Vermox\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/vermox\/\">Mebendazole<\/a> (Vermox)<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved celle i rosa, der er sk\u00e5ret op. hvid baggrund.\" class=\"wp-image-14780\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Mebendazol-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Main mechanism: Destruction of microtubules (the cell&#8217;s scaffolding)<\/li>\n\n\n\n<li>Mebendazole&#8217;s primary and most well-documented effect is a disruption of the cancer cells&#8217; internal skeleton. The substance, which belongs to the benzimidazole family, works by binding to the protein tubulin and preventing it from assembling into microtubules. This effectively stops cell division (mitosis) and leads to cell death. Mebendazole is also the benzimidazole that has been the subject of the most formal clinical investigations, especially in connection with aggressive brain tumors (glioblastoma), where it has been tested as a supplement to standard chemotherapy.<\/li>\n\n\n\n<li><strong>Characteristics:<\/strong> A direct, physical attack on the cell&#8217;s structure. It is the benzimidazole most extensively studied in human clinical trials.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fenbendazole\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/fenbendazol\/\">Fenbendazole<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved Kompliceret celle i bl\u00e5 med lyser\u00f8de enheder indeni. Bl\u00e5 baggrund.\" class=\"wp-image-14781\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Fenbendazol2-parasitaere-midler-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism:<\/strong> Destruction of microtubules (the cell&#8217;s scaffolding).<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Fenbendazole shares the same core mechanism as mebendazole, namely destroying the cancer cells&#8217; microtubules and thereby stopping cell division. Its popularity, however, is driven more by preclinical studies (laboratory and animal trials) as well as strong patient reports and compelling anecdotal evidence.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary mechanisms:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In addition to the microtubule effect, research indicates that fenbendazole has a unique ability to stress the metabolism of cancer cells by blocking their sugar uptake. Certain studies also indicate that it can reactivate the tumor-suppressor gene p53.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Characterized by having a strong anecdotal history and a research focus on its ability to create metabolic stress.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Niclosamide\"><\/span><a href=\"\/niclosamid\">Niclosamide<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved lilla celle med nogle orange enheder p\u00e5 overfladen. hvid baggrund.\" class=\"wp-image-14779\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Niclosamid-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Niclosamide takes a completely different approach, which is primarily metabolic and signal-oriented.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Metabolic collapse (energy blockade)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Niclosamide acts as an &#8220;uncoupler&#8221; in the cancer cell&#8217;s power plants, the mitochondria. It simply short-circuits the process that produces energy (ATP), leading to an immediate and fatal loss of energy in the cell. Simultaneously, massive oxidative stress is created (via ROS production), further damaging the cell.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary, but crucial mechanism: Signaling sabotage<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Beyond the energy blockade, niclosamide&#8217;s great strength is its ability to simultaneously inhibit a wide range of central signaling pathways that cancer cells depend on (Wnt, STAT3, mTOR, NF-\u03baB). This hits not only growth but also the otherwise resilient cancer stem cells.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>A dual attack that both removes the cell&#8217;s fuel and interrupts its internal communication.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Ivermectin\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/ivermectin\/\">Ivermectin<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved hudlignende struktur med forh\u00f8jning. der foreg\u00e5r proceller med dna-lignende enheder. lysebl\u00e5 baggrund \u00f8verst.\" class=\"wp-image-14778\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Ivermectin-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Ivermectin is again different from those mentioned above, working broadly on several systems related to cell stress and transport.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Induction of oxidative stress and ion imbalance<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Like niclosamide, ivermectin can create high levels of oxidative stress (ROS) that are toxic to the cancer cell. It is also believed to affect ion channels in the cell membrane, disrupting the fragile electrical balance the cell maintains.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Secondary, but crucial mechanism: Inhibition of transport pumps<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>One of the main causes of chemoresistance is that cancer cells develop pumps (such as P-glycoprotein) that actively push chemotherapy back out of the cell. Ivermectin has been shown to block these pumps. This means it can make resistant cancer cells sensitive to chemotherapy again, as the poison now remains inside the cell.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Creates internal stress and prevents the cancer cell from &#8220;pumping&#8221; out toxins.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Hydroxychloroquine_Plaquenil\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/plaquenil\/\">Hydroxychloroquine<\/a> <a href=\"https:\/\/jegharkraeft.dk\/plaquenil\/\">(Plaquenil)<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved Rosa celle der er cirkelformet. Andre enheder deri i forskellige rosa nuancer. hvid baggrund.\" class=\"wp-image-14777\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Plaquenil-parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">This drug, which is an antimalarial agent, has a very specific and unique mechanism.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Blocking autophagy (the cell&#8217;s recycling station)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Autophagy is a survival mechanism where the cell breaks down and recycles its own damaged parts to obtain energy and building blocks under pressure (e.g., during chemotherapy). Hydroxychloroquine blocks this process. The result is that the cancer cell cannot &#8220;clean up&#8221; after itself, leading to an accumulation of toxic waste inside. This makes the cell significantly more vulnerable and can push it toward cell death, especially when it is already stressed by other treatments.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Prevents the cancer cell from &#8220;eating itself&#8221; to survive pressure.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Artemisinin_and_derivatives\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/artemisia\/\">Artemisinin<\/a> (and derivatives)<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved en oversk\u00e5ret celle i rosa med en masse funktioner og molekyler og noget der ligner en sav igennem. Hvid baggrund.\" class=\"wp-image-14792\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere-artemisin-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Main mechanism: Iron-activated cell death via free radicals<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Artemisinin, originally a Nobel Prize-winning drug for malaria, has a highly effective and specific mechanism of action. Cancer cells need large amounts of iron to divide rapidly, and they therefore have a much higher concentration of iron than normal, healthy cells. The artemisinin molecule contains a special chemical structure (an endoperoxide bridge) that reacts violently when it comes into contact with iron. This reaction creates an explosion of unstable and highly damaging molecules called free radicals (specifically Reactive Oxygen Species, ROS). This internal &#8220;bomb&#8221; of oxidative stress destroys the cancer cell&#8217;s membranes, proteins, and DNA from within, forcing it into cell death. The process has similarities to a specific type of cell death called ferroptosis (iron-dependent cell death).<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Access in Denmark:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The pure, most potent substance artesunate (a derivative) is a prescription drug in Denmark, while the plant <em>Artemisia annua<\/em> is typically sold as a dietary supplement.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Characteristics:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Functions as a &#8220;Trojan horse&#8221; that exploits the cancer cell&#8217;s own iron dependency to create a targeted internal explosion.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">See also links at the bottom of this article<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Resistance_and_safety_during_long-term_use\"><\/span>Resistance and safety during long-term use<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">When using repurposed parasitic drugs in an oncological context, critical factors regarding resistance and safety apply to all the mentioned compounds.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Risk of clinical resistance<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Cancer cells are biologically extremely adaptable. While individual clinical observations may suggest a lack of resistance, extensive research documents that cancer cells can develop resistance over time. The most central mechanism is the overexpression of so-called ABC transporters (including P-glycoprotein). These function as molecular pumps that actively remove the drug from the cell&#8217;s interior before it can take effect [1, 4]. Continuous exposure without breaks can create a selection pressure, where only the most resistant cancer cells survive and multiply [2].<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The importance of monitoring<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Because cancer treatment often requires higher doses or longer durations than a standard parasite treatment, continuous monitoring is essential. This is particularly true for benzimidazoles (such as mebendazole), where long-term use is associated with the risk of drug-induced liver toxicity [3]. Monitoring with blood tests, including liver function tests (ALT\/AST), is therefore a necessary safety precaution to ensure that treatment can continue without damaging the organs.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Overview\"><\/span>Overview<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved celle med bl\u00e5 midte. derom m\u00f8rk rosa cirkelform. og udenp\u00e5 denne rosa cirkel med runde elementer i bl\u00e5 tomer. og dette omgives a forskellige symboler p\u00e5 virkninger. hvid baggrund.\" class=\"wp-image-14776\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/parasitaere-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><td><strong>Drug<\/strong><\/td><td><strong>Primary Mechanism of Action<\/strong><\/td><td><strong>Unique Characteristics<\/strong><\/td><\/tr><\/thead><tbody><tr><td>Mebendazole<\/td><td>Destruction of microtubules<\/td><td>Attacks the cell&#8217;s &#8220;skeleton.&#8221; Most studied in clinical trials.<\/td><\/tr><tr><td>Fenbendazole<\/td><td>Destruction of microtubules<\/td><td>Attacks the cell&#8217;s &#8220;skeleton.&#8221; Strong anecdotal history.<\/td><\/tr><tr><td>Niclosamide<\/td><td>Metabolic collapse (energy blockade)<\/td><td>Removes cell fuel and sabotages signaling pathways. Poor absorption.<\/td><\/tr><tr><td>Ivermectin<\/td><td>Induction of oxidative stress \/ Inhibition of pumps<\/td><td>Creates internal stress and counteracts chemoresistance.<\/td><\/tr><tr><td>Hydroxychloroquine<\/td><td>Inhibition of autophagy<\/td><td>Prevents the cell&#8217;s &#8220;recycling system&#8221; from working.<\/td><\/tr><tr><td>Artemisinin (and derivatives)<\/td><td>Iron-activated formation of free radicals (ROS)<\/td><td>Exploits high iron content in cancer cells to create oxidative stress.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion-2\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2.png\" alt=\"Parasit\u00e6re midler sammenlignet symboliseret ved Planche med celle der bliver angrebet a forskellige enheder. bl\u00e5 baggrund.\" class=\"wp-image-14782\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/07\/Parasitaere2-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">The clear conclusion is that there is no single &#8220;antiparasitic&#8221; effect against cancer. Each substance represents a unique angle of attack that exploits different vulnerabilities in the cancer cell&#8217;s complex machinery. This diversity opens the door for intelligent combination treatments, where a tumor can be hit from several sides simultaneously. In the long run, a deeper understanding of these mechanisms can lead to more tailored treatment, where the choice of a repurposed drug is based on the specific biochemical profile of the individual tumor. The potential lies not in a single &#8220;miracle cure,&#8221; but in the strategic use of an entire arsenal of different, rediscovered &#8220;keys,&#8221; each of which can unlock a new door in the cancer cell&#8217;s defense.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As these are medications, it is naturally essential to discuss their use with your healthcare provider.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/metabolisk-strategi\/\">Metabolic strategy \u2013 block signaling pathways by cancer type \u2013 chart overviews <\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are in doubt about interaction, it can be checked here: <\/p>\n\n\n\n<p class=\"has-custom-bl-links-color has-text-color has-link-color wp-elements-44e9f8537547201e0b860469b007bb4f wp-block-paragraph\"><a href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\" rel=\"noreferrer noopener\">Drugs.com<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/repurposed-drugs\">Repurposed Drugs<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/ingen-medicin-plan-b\/\">No medicine &#8211; Plan B<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Se ogs\u00e5 <a href=\"https:\/\/jegharkraeft.dk\/parasittens-vej-til-kraeft\/\">The parasite&#8217;s path to cancer<\/a><a href=\"https:\/\/jegharkraeft.dk\/repurposed-drugs\"><\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-485790e51077e9636b3d4b79d3c87ead wp-block-paragraph\"><a href=\"#menu\">(to menu)<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ivermectin:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7e9f696fce92d4cf7bec886436fdf950 wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315152\" target=\"_blank\" rel=\"noreferrer noopener\">Ivermectin, a potential anticancer drug derived from an antiparasitic agent<\/a> (Science Direct, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This article provides a broad overview of the many proposed anti-cancer mechanisms for ivermectin. It mentions, among other things, the effect on Hippo, Akt\/mTOR, and WNT signaling pathways, which supports the drug&#8217;s versatility.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2b03c9ac0cb4e98b5638f3e5cfaf7565 wp-block-paragraph\"><a href=\"https:\/\/www.embopress.org\/doi\/full\/10.15252\/emmm.201404084\" target=\"_blank\" rel=\"noreferrer noopener\">The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer<\/a> (EMBO Molecular Medicine, 2014)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> A very specific study confirming that ivermectin is an effective blocker of the WNT signaling pathway, which is a fundamental and often overactive signaling pathway in many cancers, including colorectal and breast cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0f1586025b6aa979620f414347b29e0f wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40174264\/\" target=\"_blank\" rel=\"noopener\">Targeting EGFR\/PI3K\/AKT\/mTOR and Bax\/Bcl-2\/caspase3 pathways with ivermectin mediates its anticancer effects against urethane-induced non-small cell lung cancer in BALB\/c mice<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> An animal study shows that the drug ivermectin has a strong anti-cancer effect on non-small cell lung cancer (NSCLC). The study concludes that ivermectin works by blocking the central growth signaling pathway (EGFR\/PI3K\/AKT\/mTOR), leading to increased cell death and inhibited tumor growth.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-b0958b54bba05afef792e253bf20c0a2 wp-block-paragraph\"><a href=\"https:\/\/williamscancerinstitute.com\/ivermectin-and-cancer-exploring-the-potential-link\/\" target=\"_blank\" rel=\"noopener\">Ivermectin and Cancer: Exploring the Potential Link <\/a>(Williams Cancer Institute, 2023)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Ivermectin has potential as a cancer treatment by inhibiting tumor growth, inducing apoptosis, strengthening the immune system, and preventing angiogenesis. These mechanisms may supplement existing therapies, but further clinical research is necessary. Overall, Ivermectin opens new possibilities for the development of innovative cancer treatments.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-f6d7c89947019a91fc6294d2c728a83d wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820315152?fbclid=IwY2xjawEWAGNleHRuA2FlbQIxMQABHdZYgWOdPXTAstplSsyjo-mMcyZdAVFA3Rp98ZOYM7HntHyhuuR8focP-Q_aem_0Zm90ecrP8sdxnVd2YUw4Q\" target=\"_blank\" rel=\"noopener\">Ivermectin, a potential anticancer drug derived from an antiparasitic drug<\/a> (Science Direct, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Ivermectin, an antiparasitic macrolide, has shown promising potential as a cancer treatment by inhibiting tumor cell proliferation and promoting apoptosis through multiple signaling pathways. This opens possibilities for clinical use of ivermectin as an anti-neoplastic agent. Further research is needed to realize this potential in cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Fenbendazole:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-e8ffd92d3c372aa71d43157989c29018 wp-block-paragraph\"><a href=\"https:\/\/www.onedaymd.com\/2025\/04\/fenbendazole-ivermectin-mebendazole-breast-cancer.html?m=1&amp;fbclid=IwY2xjawLLzjlleHRuA2FlbQIxMQBicmlkETB6Z3JmcTBiVjE3aWZsOVk1AR6YqtGVRRh4AKT27Xbrs1D-ZnsZhEUm0JA-kHYlQMSGDKJLlqcqwdjGKleXxA_aem_4liz50FMI2Lok_3mycN_Kw\" target=\"_blank\" rel=\"noopener\">Fenbendazole, Ivermectin and Mebendazole for Breast Cancer Success Stories \u2013 37 Case Reports<\/a> (The Medical Adviser, June 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Several peer-reviewed articles and case studies suggest that Fenbendazole, Ivermectin, and Mebendazole may play an important role in the treatment of stage 4 breast cancer. Research shows that these substances have different anti-cancer mechanisms that can be effective against cancer cells. Specific studies include a protocol for Ivermectin, as well as investigations of Fenbendazole and Mebendazole in relation to breast cancer and metastases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-13e5fb2c69e85ffcba2d5becf9402b57 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40509264\/\" target=\"_blank\" rel=\"noopener\">Fenbendazole Exhibits Antitumor Activity Against Cervical Cancer Through Dual Targeting of Cancer Cells and Cancer Stem Cells: Evidence from In Vitro and In Vivo Models<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Fenbendazole can kill both common cancer cells and the difficult cancer stem cells in cervical cancer by disrupting the cells&#8217; growth cycle. It stopped tumor growth in animal models without weight loss, in contrast to chemotherapy, and resulted in full survival in those treated. These results make fenbendazole a promising treatment choice against cervical cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7ee523fe740ebd3bc0868dae9015338d wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39736624\/\" target=\"_blank\" rel=\"noopener\">Transcriptome analysis reveals the anticancer effects of fenbendazole on ovarian cancer: an in vitro and in vivo study<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Fenbendazole can inhibit the growth and promote the death of ovarian cancer cells by disrupting the cell cycle and causing mitotic catastrophe. It was also shown to reduce tumor growth in mice, suggesting it could become a promising treatment for ovarian cancer. These results open possibilities for new therapies against this serious disease.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Mebendazole:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-0e1e33aab10563d5c30e70d2e19e78b4 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34218593\/\" target=\"_blank\" rel=\"noopener\">Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update <\/a>(PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Albendazole and mebendazole are broad-spectrum deworming medications that block microtubules and have shown promising anti-cancer effects in vitro and in vivo. They can be used against parasitic infections and potentially as cancer treatment, but long-term use can cause side effects like liver damage. Mebendazole is currently more popular in cancer trials due to albendazole&#8217;s toxicity.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-affcbe042ec922ebc83722818f345c15 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39614899\/\" target=\"_blank\" rel=\"noopener\">Synergistic inhibition of proliferation and induction of apoptosis in oral tongue squamous cell carcinoma by mebendazole and paclitaxel via PI3K\/AKT pathway mitigation<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Mebendazole and paclitaxel have a synergistic effect on inhibiting proliferation and microtubular structures in oral tongue squamous cell carcinoma (OTSCC) by inhibiting the PI3K\/AKT signaling pathway. The combination increases apoptosis markers and may be a promising treatment for OTSCC. Further research is needed to confirm their clinical potential.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-dd7d2c1cc24e31773969660ad3fc7bb1 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/39527027\/\" target=\"_blank\" rel=\"noopener\"><em>In vitro<\/em>&nbsp;evaluation of lipidic nanocarriers for mebendazole delivery to improve anticancer activity<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Mebendazole nanostructures (MBZ-NLCs) are stable and contain a larger portion of the active substance than standard forms. They are ten times more effective against cancer cells and can prevent the movement of cancer cells in laboratory experiments. The results suggest that mebendazole nanostructures could become a good treatment for lung cancer, but more tests in the body are needed.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Plaquenil:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-d554516ea4c3ee7a986f5a34bdafc977 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40185322\/\" target=\"_blank\" rel=\"noopener\">The imidazoline I<sub>2<\/sub>&nbsp;receptor agonist 2-BFI enhances cytotoxic activity of hydroxychloroquine by modulating oxidative stress, energy-related metabolism and autophagic influx in human colorectal adenocarcinoma cell lines<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> A new study shows that the substance 2-BFI (an imidazoline I2-receptor agonist) significantly enhances the cell-killing effect of the autophagy inhibitor hydroxychloroquine (HCQ) against colorectal cancer cells. The combination works by creating increased oxidative stress and disrupting cancer cell metabolism and survival mechanisms.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-3fde295fa4b3eb3271b0e84bae3f79b4 wp-block-paragraph\"><a href=\"https:\/\/www.upmc.com\/media\/news\/030922-malaria-drug-chemotherapy\" target=\"_blank\" rel=\"noreferrer noopener\">Malaria Drug Could Combat Chemotherapy-Resistant Head and Neck Cancers<\/a> (UPMC, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance: <\/strong>This is an easy-to-understand summary of a study that shows a concrete example of how hydroxychloroquine is used to overcome chemo-resistance. It explains how the substance can &#8220;re-sensitize&#8221; cancer cells so that chemotherapy works again.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-47152620ee02d49434ca011b60f5f8fc wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC5718030\/\" target=\"_blank\" rel=\"noopener\">Repurposing Drugs in Oncology (ReDO)\u2014chloroquine and hydroxychloroquine as anti-cancer agents <\/a>(PubMed, 2017)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Chloroquine (CQ) and hydroxychloroquine (HCQ) have potential as anti-cancer treatment, especially in combination with standard therapies. They affect both cancer cells and the tumor microenvironment through autophagy inhibition and modulation of signaling pathways such as p53 and CXCR4-CXCL12. Further clinical studies are necessary to optimize dosing and treatment regimens.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Niclosamide:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-67a4902e9e2dd083baa0cf254855860e wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40446543\/\" target=\"_blank\" rel=\"noopener\">Computer-aided drug discovery of a dual-target inhibitor for ovarian cancer: therapeutic intervention targeting CDK1\/TTK signaling pathway and structural insights in the NCI-60<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This study identified 35 genes, including CDK1 and TTK, as important targets in ovarian cancer, which often develops resistance to treatment. NSC765690 (MCC22) was found to be a promising niclosamide analog with strong activity against both targets, which may help overcome chemotherapy resistance. The results show a data-driven approach to developing new therapies for ovarian cancer.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-342d3eca819bc491552472a375c47e44 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40521512\/\" target=\"_blank\" rel=\"noopener\">Niclosamide Treatment Suppressed Metastatic, Apoptotic, and Proliferative Characteristics of MDA-MB-231 Cancer Stem Cells<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This study showed that niclosamide effectively induces apoptosis and stops the cell cycle in aggressive triple-negative breast cancer-CSCs in a 3D model. The treatment reduced metastasis- and resistance-related genes as well as EMT markers, which may improve treatment effectiveness against cancer. The results suggest that niclosamide can increase CSC sensitivity and prevent tumor recurrence.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4def919f735299993d08bb6a73814c2c wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40153934\/\" target=\"_blank\" rel=\"noopener\">Pharmacological advances and therapeutic applications of niclosamide in cancer and other diseases<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Niclosamide is an FDA-approved drug with potential in cancer treatment, especially against resistant ovarian cancer, by modulating cell proliferation and apoptosis. New formulations and nanotechnology improve bioavailability, strengthening its therapeutic possibilities. It shows promising versatility in the treatment of cancer, viral infection, and inflammatory diseases.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7ae98a01281a9f617c318c7a12f8a6a5 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40466616\/\" target=\"_blank\" rel=\"noopener\">Study on the mechanism of niclosamide ethanolamine salt-hydroxypropyl-\u03b2-cyclodextrin in the treatment of colon cancer based on metabolomics and 16S rRNA technology<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> NHC, an improved form of niclosamide, shows increased solubility and potential as a treatment for colon cancer. The analysis confirms that NHC is more effective than NES, and metabolomics as well as 16S rRNA investigate its mechanism. This may open new possibilities for niclosamide-based cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-28451a47f3f0c384dbad5b7c5805b9ae wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38820079\/\" target=\"_blank\" rel=\"noopener\">Antitumor activity of niclosamide-mediated oxidative stress against acute lymphoblastic leukemia<\/a> (PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Niclosamide was shown to be able to inhibit growth and induce apoptosis in acute lymphoblastic leukemia (ALL) by increasing reactive oxygen species and activating TP53. It has potential as a new treatment to improve response and extend survival in ALL patients. These results indicate that niclosamide could become a promising therapeutic agent against ALL.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>In General:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-4d441217b21e505edf15434d60035b2b wp-block-paragraph\"><a href=\"https:\/\/isom.ca\/wp-content\/uploads\/2024\/09\/Targeting-the-Mitochondrial-Stem-Cell-Connection-in-Cancer-Treatment-JOM-39.3.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Targeting the Mitochondrial-Stem Cell Connection in Cancer<\/a> <a href=\"https:\/\/isom.ca\/wp-content\/uploads\/2024\/09\/Targeting-the-Mitochondrial-Stem-Cell-Connection-in-Cancer-Treatment-JOM-39.3.pdf\" target=\"_blank\" rel=\"noreferrer noopener\">Treatment: A Hybrid Orthomolecular Protocol<\/a> (Journal of Orthomolecular Medicine)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-cc085c5155dfa1316a96e7e54c08dd01 wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noopener\">Interactions (search for preparations) <\/a>(Interaktionsdatabasen, Danish Medicines Agency)<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Resistens og monitorering<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc50e57b1dcd262340691d7522606ebb wp-block-paragraph\">[1]&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S136876462500113X\" target=\"_blank\" rel=\"noreferrer noopener\">The emerging roles of ATP-binding cassette transporters in cancer multidrug resistance<\/a>&nbsp;(ScienceDirect, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A fully updated review of how ABC transporters function as pumps that create resistance in cancer cells. The article describes the challenges of overcoming this mechanism to ensure effective drug delivery.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-1b60c85aac181848ef6d7bd45bcb2f98 wp-block-paragraph\">[2]&nbsp;<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4096024\/\" target=\"_blank\" rel=\"noreferrer noopener\">Repurposing Drugs in Oncology (ReDO)\u2014A project to find new uses for old drugs<\/a>&nbsp;(ecancer, 2014)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A comprehensive article series reviewing the need for monitoring and the theoretical risks of resistance when moving drugs from short-term use to long-term cancer treatment.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-9abe0ae75071ee5e759625425fcaccf9 wp-block-paragraph\">[3]&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34218593\/\" target=\"_blank\" rel=\"noreferrer noopener\">Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update<\/a>&nbsp;(PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: An article based on a review of benzimidazoles (mebendazole and albendazole). It describes their anti-cancer effects but explicitly states that long-term use can cause side effects such as liver damage.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-669070973af0f414a0297a370aada789 wp-block-paragraph\">[4]&nbsp;<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29643473\/\" target=\"_blank\" rel=\"noreferrer noopener\">Revisiting the role of ABC transporters in multidrug-resistant cancer<\/a>&nbsp;(PubMed, 2018)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Content: A scientific article documenting how the overexpression of ABC transporters (especially P-glycoprotein) in cancer cells is a major cause of multidrug resistance. The study demonstrates that these pumps effectively remove drugs from cells, thereby blocking their efficacy.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> July 1, 2024, Last revised July 28, 2026<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_84 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Treatments\" >Treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Complementary_and_Alternative_Treatments\" >Complementary and Alternative Treatments<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Ivermectin_and_cancer\" >Ivermectin and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Ivermectin_in_a_cancer_strategy\" >Ivermectin in a cancer strategy<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Tip_for_absorption\" >Tip for absorption<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Attack_on_cancer_stem_cells\" >Attack on cancer stem cells<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Stop_the_invasion\" >Stop the invasion<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Blocking_resistance\" >Blocking resistance<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Ivermectins_effect\" >Ivermectin&#8217;s effect<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Immune_effect\" >Immune effect<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Synergy_with_other_agents\" >Synergy with other agents<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Safety_and_precautions\" >Safety and precautions<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Warning\" >Warning<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Research\" >Research<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Conclusion\" >Conclusion<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Fat-rich_foods_with_a_high_content_of_healthy_fat\" >Fat-rich foods with a high content of healthy fat<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Antiparasitic_drugs_%E2%80%93_compariso\" >Antiparasitic drugs &#8211; compariso<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Antiparasitic_agents_compared\" >Antiparasitic agents compared<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Mebendazole_Vermox\" >Mebendazole (Vermox)<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Fenbendazole\" >Fenbendazole<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Niclosamide\" >Niclosamide<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Ivermectin\" >Ivermectin<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Hydroxychloroquine_Plaquenil\" >Hydroxychloroquine (Plaquenil)<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Artemisinin_and_derivatives\" >Artemisinin (and derivatives)<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Resistance_and_safety_during_long-term_use\" >Resistance and safety during long-term use<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Overview\" >Overview<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/jegharkraeft.dk\/en\/ivermectin\/#Conclusion-2\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatments Complementary and Alternative Treatments Ivermectin and cancer Content: Summary of Ivermectin Strategic purpose: Mechanisms: Role in treatment: Ivermectin in a cancer strategy Ivermectin (brand names such as Stromectol and Scabior) is originally known as an antiparasitic agent that has saved millions from river blindness. However, in modern integrative oncology, the substance has achieved status [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":39962,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[393,375,374,396],"tags":[],"class_list":["post-33007","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-repurposed-drugs","category-alternative-treatments","category-treatments","category-immunomodulatory-agents"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33007","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=33007"}],"version-history":[{"count":3,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33007\/revisions"}],"predecessor-version":[{"id":39986,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/33007\/revisions\/39986"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/39962"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=33007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=33007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=33007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}