{"id":32966,"date":"2025-03-21T19:25:38","date_gmt":"2025-03-21T18:25:38","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=32966"},"modified":"2026-04-11T18:56:23","modified_gmt":"2026-04-11T17:56:23","slug":"propranolol","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/propranolol\/","title":{"rendered":"Propranolol and cancer"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-fad5d37762a91660661560b4edeef574 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-85c9ab605a9af581478ba1bfba8fd611\"><span class=\"ez-toc-section\" id=\"Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/cancer-treatments-overview\/\">Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<h3 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-52532d4beacf4a32227a79286a8276fc\"><span class=\"ez-toc-section\" id=\"Complementary_and_Alternative_Treatments\"><\/span><a href=\"https:\/\/jegharkraeft.dk\/en\/alternative-cancer-treatments-overview\/\">Complementary and Alternative Treatments<\/a><span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-8d24fd871cbdd212cc77ff2b29ee5eaf has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c9da2d255afe17796dc47aa09c4b623\"><a href=\"https:\/\/jegharkraeft.dk\/en\/akupunktur\/\">Physical treatments<\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6d46083b359288fdbe742e9912e022fd\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Repurposed Drugs &#8211; General<\/mark><\/a>\n<ol class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-780fac237d6d09f0087842050420bfba\"><a href=\"https:\/\/jegharkraeft.dk\/en\/aspirin\/\">Painkillers and anti-inflammatory drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-fc195be5f8f032f0598dc44213706abd\"><a href=\"https:\/\/jegharkraeft.dk\/en\/dipyridamole\/\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-hvid-tekst-color\">Heart and circulatory medications<\/mark><\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-449ace9899a7c40526cf7c31cee822bf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/dipyridamole\/\">Dipyridamole<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-5a7d16b763464cc1f47d790b3967f7dd\"><a href=\"#propranolol\">Propranolol (scroll down)<\/a><\/li>\n\n\n\n<li><a href=\"https:\/\/jegharkraeft.dk\/en\/statins\/\">Statins<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-110ab3157ece675d1aeb7921af0e506a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/doxycycline\/\">Antibiotics and antiparasitic agents<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-a99575c8ffb4e827783ab6d56f16ed45\"><a href=\"https:\/\/jegharkraeft.dk\/en\/metformin\/\">Diabetes medication<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-6c31e64b006d888e2e94cb9770a3c32c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/low-dose-naltrexone\/\">Agents affecting hormones and signaling substances<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-dd7ca0bc23a9ec3ca6e860ef8de7693a\"><a href=\"https:\/\/jegharkraeft.dk\/en\/disulfiram\/\">Other medications<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-66a0e4204f5201bcc8494f5822b38efe\"><a href=\"https:\/\/jegharkraeft.dk\/en\/the-coc-protocol\/\">COC Protocol<\/a><\/li>\n<\/ol>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9504e56e950d068c15963cbdbf1fdaaf\"><a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b\/\">No medication \u2013 Plan B<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50bb8d7b4bb216418ba3c0d4a402648c\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-chemotherapy\/\">Repurposed drugs and chemotherapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-af88e7f595afd58f141d2c174a141555\"><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs-and-radiotherapy\/\">Repurposed drugs and radiation therapy<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7098df34ebce445cd1790d85e10991eb\"><a href=\"https:\/\/jegharkraeft.dk\/en\/flcccs-ranking\/\">FLCCC\u2019s ranking of repurposed drugs<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-4c827eb85783b3d07583409effc04d57\"><a href=\"https:\/\/jegharkraeft.dk\/en\/brain-metastases-and-bloodbrain-barrier\/\">Brain metastases and the blood-brain barrier<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-cf6cfac91ed1b7d193bc5d25a711b818\"><a href=\"https:\/\/jegharkraeft.dk\/en\/bombs-fire-extinguishers-and-timing\/\">Bombs, fire extinguishers, and timing<\/a><\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"2560\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_.jpg\" alt=\"Propranolol illustreret ved hvid og brunt papemballage fra Actavis med p\u00e5skriften Propranolol Tablets. 28 tablets.\" class=\"wp-image-32965\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_.jpg 2560w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-300x300.jpg 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-100x100.jpg 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-600x600.jpg 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-1024x1024.jpg 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-150x150.jpg 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-768x768.jpg 768w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-1536x1536.jpg 1536w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_-2048x2048.jpg 2048w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;http:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/02\/bPropranolol.red_.jpg&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-8bddf08b\">\n<h1 class=\"wp-block-heading\" id=\"propranolol\"><span class=\"ez-toc-section\" id=\"Propranolol_and_cancer\"><\/span>Propranolol and cancer<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<h4 class=\"wp-block-heading\">What is propranolol<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Propranolol is primarily known as a beta-blocker used to treat a range of heart conditions, such as high blood pressure and heart rhythm disorders. In recent years, however, there has also been increasing interest in propranolol&#8217;s potential role in cancer treatment and the prevention of cancer recurrence.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Effect_of_propranolol_in_cancer\"><\/span>Effect of propranolol in cancer<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">How does propranolol work in connection with cancer<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Stress reduction<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Propranolol can help reduce stress hormones that can negatively affect the immune system. A weakened immune system may have difficulty fighting cancer cells.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Blood vessel growth<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Cancer tumors need a good blood supply to grow. Propranolol can inhibit the formation of new blood vessels, which can limit tumor growth.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cell signaling<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Propranolol can affect various cell signaling pathways involved in cancer cell division and spread.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Note\"><\/span>Note<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Propranolol is relatively inexpensive and has a good safety profile. This makes it an attractive candidate as a repurposed drug for cancer treatment. Additionally, propranolol&#8217;s anti-inflammatory effects may be further beneficial in cancer treatment.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Furthermore, be aware that certain drugs can interact, so unintended effects may occur when these are combined.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">If you are in doubt, it can be checked here:<\/p>\n\n\n\n<p class=\"has-custom-bl-links-color has-text-color has-link-color wp-elements-4ccbb8e277197c0d02ed51a0e304ec20 wp-block-paragraph\"><a href=\"https:\/\/www.drugs.com\/?fbclid=IwZXh0bgNhZW0CMTAAAR2Un76TmB0Yk4p7gHQ4TUFL7cCg_ob3aVB1DcZjT48o-YwFap8riMvnNiQ_aem__ZDuOwAdzVO0yZi5iJKihQ\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Drugs.com<\/strong><\/a><\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Side_effects\"><\/span>Side effects<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Like all other medications, propranolol can cause side effects, although not everyone experiences them.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Common side effects<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The most common side effects of propranolol include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Fatigue:<\/strong> Many experience a feeling of tiredness or lethargy, especially at the start of treatment.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Dizziness:<\/strong> This can be caused by a sudden drop in blood pressure, especially when standing up quickly.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cold hands and feet:<\/strong> Propranolol can decrease blood flow to the extremities (arms, legs, hands, and feet).<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Stomach pain:<\/strong> Some experience stomach pain, nausea, or diarrhea.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Sleep disturbances:<\/strong> This can include nightmares or trouble falling asleep.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Depression:<\/strong> In rare cases, propranolol can worsen existing depression or trigger new depressive symptoms.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Less common side effects<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Heart problems:<\/strong> Although propranolol is often used to treat heart issues, in rare cases it can worsen existing heart conditions or cause new ones.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Breathing difficulties:<\/strong> Propranolol can worsen asthma or other lung diseases.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Skin reactions:<\/strong> Rashes or itching may occur.<\/li>\n<\/ul>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Sexual problems:<\/strong> Men may experience decreased libido or impotence.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"What_the_research_shows\"><\/span>What the research shows<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Promising results<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">There are several promising research studies suggesting that propranolol may have a positive effect on certain types of cancer, particularly in connection with:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Lovende resultater<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Sarcomas:<\/strong> The combination of propranolol and <a href=\"https:\/\/jegharkraeft.dk\/en\/immunterapi\/\">immunotherapy<\/a> has shown promising results in treating certain types of sarcomas.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Breast cancer:<\/strong> Studies suggest that propranolol can have a positive effect by inhibiting the spread of <a href=\"https:\/\/jegharkraeft.dk\/en\/brystkraeft\/\">breast cancer.<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Esophageal cancer:<\/strong> Propranolol is being investigated as a potential treatment for <a href=\"https:\/\/jegharkraeft.dk\/en\/spiseroerskraeft\/\">esophageal cancer<\/a>, where it may increase the effectiveness of <a href=\"https:\/\/jegharkraeft.dk\/en\/immunterapi\/\">immunotherapy<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Other cancers:<\/strong> There are also preliminary studies on propranolol&#8217;s potential in connection with other cancers, such as <a href=\"https:\/\/jegharkraeft.dk\/en\/prostatakraeft\/\">prostate cancer<\/a> and neuroblastoma.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Improved_survival\"><\/span>Improved survival<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Some studies have shown that propranolol can improve survival in patients with cancer. For example, one study showed that breast cancer patients taking propranolol had a significantly lower mortality rate compared to patients not taking propranolol. This can indeed seem interesting for us breast cancer patients, even though definitive and fully comprehensive research has not yet been conducted on this topic.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Conclusion\"><\/span>Conclusion<span class=\"ez-toc-section-end\"><\/span><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Propranolol is an interesting drug with the potential to play a role in future cancer treatment. More research is needed to establish propranolol&#8217;s precise role in cancer therapy and to identify the patients who may benefit most from this treatment. (But quite a few of us cancer patients probably don&#8217;t have the time to wait for someone to feel like researching something that has no economic interest. So Gemini can easily hold that opinion\u2026).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\">Repurposed Drugs<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">See also <a href=\"https:\/\/jegharkraeft.dk\/en\/no-medicine-plan-b-2\/\">No medicine &#8211; Plan B<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><\/a><\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-c20aaf8639fe4bc173676d2851829423 wp-block-paragraph\"><a href=\"#menu\">(til menu)<\/a><a href=\"https:\/\/jegharkraeft.dk\/en\/repurposed-drugs\/\"><\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-9a0665688b68826b81e07b5b82ac26c1 wp-block-paragraph\"><a href=\"https:\/\/www.interaktionsdatabasen.dk\/\" target=\"_blank\" rel=\"noopener\">Interactions (search for preparations) <\/a>(Interaktionsdatabasen, Danish Medicines Agency) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-eb654f6c63d1f548a8e8b1a7a35d632b wp-block-paragraph\"><a href=\"https:\/\/journals.viamedica.pl\/oncology_in_clinical_practice\/article\/view\/OCP.2022.0016\" target=\"_blank\" rel=\"noreferrer noopener\">Oncology<\/a> (Benefits of \u03b2-blockers in cancer treatment)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-19e4a99f3df62d2eab10c507915a0386 wp-block-paragraph\"><a href=\"https:\/\/dagensmedicin.dk\/betablokkere-kan-forbedre-effekten-immunterapi\/\" target=\"_blank\" rel=\"noopener\">Dagens Medicin <\/a>(Can improve the effect of Immunotherapy) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-04655988c828a2950f8cf4f684ff6335 wp-block-paragraph\"><a href=\"https:\/\/forskning.ruc.dk\/da\/publications\/blockade-of-beta-adrenergic-receptors-reduces-cancer-growth-and-e\" target=\"_blank\" rel=\"noopener\">Research RUC<\/a> (Reduces tumor growth) (Danish Language)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-6b2b0faf3dc28a8ad353d80909a5c93a wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33782804\/\" target=\"_blank\" rel=\"noreferrer noopener\">Propranolol suppresses gastric cancer cell growth by regulating proliferation and apoptosis<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-8ec6a75b06e2fcd473d02999faf44e04 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36598324\/\" target=\"_blank\" rel=\"noreferrer noopener\">Anti-proliferative effects of beta-blocker propranolol on human lung cancer and noncancer cells<\/a> (PubMed)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-7481e0dc3e693a39015ae1a3bfdcef83 wp-block-paragraph\"><a href=\"https:\/\/www.authorea.com\/users\/498160\/articles\/579001-repurposing-propranolol-to-improve-cancer-therapy-in-clinic-where-are-we\" target=\"_blank\" rel=\"noopener\">Repurposing propranolol to improve cancer therapy in clinic: where are we?<\/a> (Authorea, 2022)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Propranolol, already repurposed for certain tumors, is increasingly showing itself to be a safe and promising strategy against many different types of cancer. Clinical data supports its potential as a broad-spectrum anticancer agent with low toxicity and cost-effectiveness.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-973572f48c06bbbb962b9c6ea744bcb1 wp-block-paragraph\"><a href=\"https:\/\/ecancer.org\/en\/journal\/article\/680-repurposing-drugs-in-oncology-redo-propranolol-as-an-anti-cancer-agent\" target=\"_blank\" rel=\"noopener\">Repurposing Drugs in Oncology (ReDO)\u2014Propranolol as an anti-cancer agent<\/a> (eCancer Medical Science, 2016)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> The beta-blocker propranolol shows promising anti-cancer effects by inhibiting cell growth and spread, especially metastasis occurring after surgery. It is currently being investigated in a range of clinical trials to confirm its efficacy as a safe and affordable treatment option.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2ad9dc5169d0308c2a51b8c235a52489 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/40361395\/\" target=\"_blank\" rel=\"noopener\">Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy<\/a> (PubMed, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> These results suggest that propranolol could be a promising add-on treatment along with capecitabine against colorectal cancer, particularly in HT-29 cells with B-RAF V600E mutations. The study highlights the potential for inducing ferroptosis as a novel therapeutic mechanism in oncology.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc0d69bab6694166f3b2fc02e1a45761 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/38857055\/\" target=\"_blank\" rel=\"noopener\">Role of transforming growth factor-\u03b21 pathway in angiogenesis induced by chronic stress in colorectal cancer <\/a>(PubMed, 2024)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> Findings show that norepinephrine affects tumor angiogenesis and that TGF-\u03b21 is vital in this process. Stress can weaken the effectiveness of anti-angiogenic treatment via a specific signaling pathway involving \u03b2-AR and VEGF, suggesting that beta-blockers may mitigate these stress effects.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-79b2dde1c0046f8c3e5b4e25cbf5dea2 wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31754048\/\" target=\"_blank\" rel=\"noopener\">Preoperative \u03b2-Blockade with Propranolol Reduces Biomarkers of Metastasis in Breast Cancer: A Phase II Randomized Trial<\/a> (PubMed, 2020)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This randomized Phase II trial of 60 patients receiving preoperative propranolol showed significant downregulation of genes linked to cancer spread and increased infiltration of immune cells like NK and CD8+ T-cells. This suggests that beta-blockade can reduce biomarkers of metastasis.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-f2c8e41b98b40b1f21c8039136b16d66 wp-block-paragraph\"><a href=\"https:\/\/www.thelancet.com\/article\/S2352-3964(16)30065-2\/fulltext\" target=\"_blank\" rel=\"noopener\">Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study<\/a> (The Lancet \/ EBioMedicine, 2016)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This non-randomized Phase II pilot study shows that 40 mg of propranolol twice daily combined with metronomic chemotherapy yielded a 100% response rate in advanced angiosarcoma. The synergy between drugs blocked beta-adrenergic receptors and extended median survival to sixteen months.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc832d5eefc4f31e8c7de2885b376e0c wp-block-paragraph\"><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33127652\/\" target=\"_blank\" rel=\"noopener\">Phase I Clinical Trial of Combination Propranolol and Pembrolizumab in Locally Advanced and Metastatic Melanoma: Safety, Tolerability, and Preliminary Evidence of Antitumor Activity<\/a> (PubMed, 2021)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Relevance:<\/strong> This Phase I dose-escalation trial shows that combining propranolol and pembrolizumab is safe for metastatic melanoma. At the recommended Phase II dose of 30 mg twice daily, an objective response rate of 78% was achieved, accompanied by favorable changes in cytokines IFN\u03b3 and IL6.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Page created:<\/strong> July 2, 2024, Last revised February 24, 2026<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>What you read on Jeg har Kr\u00e6ft is not a recommendation. Seek competent guidance.<\/em><\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_85 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Treatments\" >Treatments<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Complementary_and_Alternative_Treatments\" >Complementary and Alternative Treatments<\/a><\/li><\/ul><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Propranolol_and_cancer\" >Propranolol and cancer<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Effect_of_propranolol_in_cancer\" >Effect of propranolol in cancer<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Note\" >Note<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Side_effects\" >Side effects<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#What_the_research_shows\" >What the research shows<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Improved_survival\" >Improved survival<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/jegharkraeft.dk\/en\/propranolol\/#Conclusion\" >Conclusion<\/a><\/li><\/ul><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Treatments Complementary and Alternative Treatments Propranolol and cancer What is propranolol Propranolol is primarily known as a beta-blocker used to treat a range of heart conditions, such as high blood pressure and heart rhythm disorders. In recent years, however, there has also been increasing interest in propranolol&#8217;s potential role in cancer treatment and the prevention [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":32965,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[393,375,374,394],"tags":[],"class_list":["post-32966","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-repurposed-drugs","category-alternative-treatments","category-treatments","category-cell-cycle-and-angiogenesis-inhibitors"],"modified_by":"Hanne Kj\u00e6r Uhlig","wpml_current_locale":"en_US","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/32966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=32966"}],"version-history":[{"count":1,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/32966\/revisions"}],"predecessor-version":[{"id":33831,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/32966\/revisions\/33831"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/32965"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=32966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=32966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=32966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}