{"id":19136,"date":"2025-08-18T21:14:47","date_gmt":"2025-08-18T20:14:47","guid":{"rendered":"https:\/\/jegharkraeft.dk\/?p=19136"},"modified":"2025-12-12T12:29:32","modified_gmt":"2025-12-12T11:29:32","slug":"lokal-behandling-global-effekt","status":"publish","type":"post","link":"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/","title":{"rendered":"Lokal behandling, global effekt. Immunterapi. Kr\u00e6ftforskning. Ny kr\u00e6ftbehandling. 2141-V11. CD40-agonist. Systemisk effekt. Tr\u00e6ning af immunsystemet gennem bare en kr\u00e6ftknude."},"content":{"rendered":"\n<div class=\"wp-block-group alignfull is-style-section-5 has-contrast-color has-base-background-color has-text-color has-background has-link-color wp-elements-3c9cd4cada38f0b3082ba074e75f33e3 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained is-style-section-5--2\" id=\"menu\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-ca2dd60b wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h2 class=\"wp-block-heading has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-245543f2404cb5e30fe087e0e4dcc210\"><span class=\"ez-toc-section\" id=\"Nyeste\"><\/span><a href=\"\/nyeste\">Nyeste<\/a><span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<div class=\"wp-block-group has-custom-interne-links-color has-text-color has-link-color wp-elements-9772d8c554df51fa9ef62dd94007c3c4 has-global-padding is-layout-constrained wp-block-group-is-layout-constrained\">\n<p class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-0deea3a4970d5605a4e130eac83c1e85 wp-block-paragraph\"><a href=\"https:\/\/jegharkraeft.dk\/forskning\/\">Forskning<\/a><\/p>\n\n\n\n<ol class=\"wp-block-list has-custom-hvid-tekst-color has-text-color has-link-color wp-elements-bc16c14f92ad181ddf41993cb507c268\">\n<li><a href=\"http:\/\/jegharkraeft.dk\/ferroptose-forskning\">Behandlingsteknikker og interventioner<\/a>\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-81655c1cfc1389ef9d503c746409056a\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-her-st-r-du-color\"><a href=\"https:\/\/jegharkraeft.dk\/ferroptose-forskning\/\">Ferroptose og kr\u00e6ftbehandling<\/a><\/mark><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-570ce4a8e1edbf88f978ce37bcdbe0f1\"><a href=\"https:\/\/jegharkraeft.dk\/mebendazole-forskning\">Mebendazol h\u00e6mmer spredning af kr\u00e6ft<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-c19b81dd8f651b9d7708df758892fb7c\"><a href=\"https:\/\/jegharkraeft.dk\/citruspektin-forskning\">Modificeret citrus pektin til behandling af prostatakr\u00e6ft<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-50ba571ff997bd2e46fd1d461afc4f8e\"><a href=\"https:\/\/jegharkraeft.dk\/benein-forskning\/\">BENEIN &#8211; Computerprogram til omprogrammering af kr\u00e6ftceller<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-ab1dc344ebc182da75c8adddca8357de\"><a href=\"https:\/\/jegharkraeft.dk\/protokol-mod-kraeft-forskning\/\">Forslag til protokol mod kr\u00e6ft &#8211; del 2<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-d0b8541b016cd931de402d2b7e1f3f3d\"><a href=\"https:\/\/jegharkraeft.dk\/ai-kraft\/\">AI og kr\u00e6ft<\/a><\/li>\n\n\n\n<li class=\"has-custom-her-st-r-du-color has-text-color has-link-color wp-elements-dd1f06efc1844198ecb362a891a318dd\"><a href=\"#lokal-behandling\">Lokal behandling, global effekt (scroll ned)<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-c7b9e1748ffd5d15b432dfa23e84ef80\"><a href=\"https:\/\/jegharkraeft.dk\/metabolisk-protokol-forskning\/\">Metabolisk behandling mod kr\u00e6ft \u2013 Del 1.<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-ed5ab31153a7bb66d86bd71bd3131b80\"><a href=\"https:\/\/jegharkraeft.dk\/om-mitokondrier-forskning\/\">Om mitokondrierne &#8211; hvad er det<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-3b637c2375a557dd1b203511edffff7a\"><a href=\"\/meta-analyse-cannabis\">Meta-analyse: Cannabis ved kr\u00e6ft<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-9f487b197a90d2ca008b4ef3cfaa226a\"><a href=\"https:\/\/jegharkraeft.dk\/statiner-reducerer-risiko-for-brystkraeft\/\">Statiner reducerer risiko for tilbagefald ved brystkr\u00e6ft<\/a><\/li>\n<\/ul>\n<\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7ecf5432dbafff7918b2756478ae23d2\"><a href=\"https:\/\/jegharkraeft.dk\/upar-forskning\">Diagnostik og biomark\u00f8rer<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-ffda71bd26d4b32a4e31be8d5d57ac80\"><a href=\"https:\/\/jegharkraeft.dk\/dine-immunceller-er-hvad-du-spiser-forskning\/\">Forebyggelse og sundhedsfremme<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-98765b092d258b3e28331615a06a753d\"><a href=\"https:\/\/jegharkraeft.dk\/dine-immunceller\">Immunsystemet og sygdom<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-8b01173e56cab508c22af8657e52a9fb\"><a href=\"https:\/\/jegharkraeft.dk\/protokol-mod-kraeft-forskning\/\">Kliniske fors\u00f8g og protokoller<\/a><\/li>\n\n\n\n<li class=\"has-custom-int-link-p-sort-1-color has-text-color has-link-color wp-elements-7dec9c6021bff32252b0c444dcce56c0\"><a href=\"https:\/\/jegharkraeft.dk\/fruktose-og-kraeft-forskning\/\">Kost, livsstil og personlig medicin<\/a><\/li>\n<\/ol>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:50%\">\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt.png\" alt=\"Lokal behandling, global effekt symboliseret ved en lilla tumor der f\u00e5r indspr\u00f8jtet et bl\u00e5t middel. m\u00f8rk baggrund.\" class=\"wp-image-19137\" style=\"aspect-ratio:3\/2;object-fit:cover;width:550px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-group alignfull is-style-default has-global-padding is-layout-constrained wp-container-core-group-is-layout-b040ace0 wp-block-group-is-layout-constrained has-background\" style=\"margin-top:0;margin-bottom:0;padding-top:var(--wp--preset--spacing--60);padding-right:var(--wp--preset--spacing--20);padding-bottom:var(--wp--preset--spacing--60);padding-left:var(--wp--preset--spacing--20);background-image:url(&apos;https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt.png&apos;);background-position:44% 36%;background-size:cover;\">\n<div class=\"gb-element-b4bbae50\">\n<h1 class=\"wp-block-heading\" id=\"lokal-behandling\"><span class=\"ez-toc-section\" id=\"Lokal_behandling_global_effekt_%E2%80%93_Ny_immunterapi_fjerner_kraeft_i_forsog\"><\/span>Lokal behandling, global effekt &#8211; Ny immunterapi fjerner kr\u00e6ft i fors\u00f8g<span class=\"ez-toc-section-end\"><\/span><\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Kilde:<\/strong><\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-fe6b44913e4e8215c1306b970bb2a611 wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1535610825003198\" target=\"_blank\" rel=\"noopener\">Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer<\/a> (Science Direct, 2025)<\/p>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc351e71880768ffeaccb75572d5f9b1 wp-block-paragraph\"><a href=\"https:\/\/www.rockefeller.edu\/news\/38120-immunotherapy-drug-eliminates-aggressive-cancers-in-clinical-trial\/\" target=\"_blank\" rel=\"noopener\">Immunotherapy drug eliminates aggressive cancers in clinical trial <\/a>(Rockefeller University, 2025)<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h4 class=\"wp-block-heading\">Resum\u00e9 <\/h4>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Imponerende resultat:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Et nyt eksperimentelt l\u00e6gemiddel, 2141-V11, har vist bem\u00e6rkelsesv\u00e6rdige resultater i et tidligt studie med mennesker. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ved at injicere stoffet direkte ind i en enkelt kr\u00e6fttumor, lykkedes det forskere at aktivere kroppens immunforsvar til at angribe og fjerne kr\u00e6ft i hele kroppen.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Stadig lille studie:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">I et fors\u00f8g med 12 deltagere med aggressiv hud- og brystkr\u00e6ft oplevede halvdelen, at deres tumorer svandt ind. Hos to af deltagerne forsvandt alle tegn p\u00e5 kr\u00e6ft. Metoden ser ud til at have f\u00e6rre alvorlige bivirkninger end tidligere lignende fors\u00f8g. Selvom resultaterne er lovende, er studiet lille, og der er behov for mere forskning.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-text-color has-custom-sort-tekst-color has-alpha-channel-opacity has-custom-sort-tekst-background-color has-background\"\/>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Et_nyt_immunterapeutisk_princip\"><\/span>Et nyt immunterapeutisk princip<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4.png\" alt=\"Lokal behandling, global effekt symboliseret ved en lysende celle i midten og fangarme ud til siden. Der spr\u00f8jtes noget ind i cellen. M\u00f8rk baggrund.\" class=\"wp-image-19141\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt4-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Forskere fra Rockefeller University i USA har pr\u00e6senteret resultater, der t\u00e6nder et nyt h\u00e5b inden for immunterapi. Deres tilgang er baseret p\u00e5 et simpelt, men kraftfuldt princip: <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>I stedet for at behandle hele kroppen med medicin, der gives i blodbanen, injiceres et specialudviklet l\u00e6gemiddel direkte ind i \u00e9n enkelt, tilg\u00e6ngelig kr\u00e6fttumor.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Tanken er at bruge den ene tumor som en slags tr\u00e6ningslejr for kroppens immunforsvar. <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>N\u00e5r immunforsvaret er aktiveret og tr\u00e6net lokalt, kan det selv genkende og bek\u00e6mpe kr\u00e6ftceller i resten af kroppen. <\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">I det f\u00f8rste fors\u00f8g p\u00e5 mennesker har denne metode vist sig ikke kun at v\u00e6re effektiv, men ogs\u00e5 at have en overkommelig bivirkningsprofil.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Fra_systemisk_til_lokal_aktivering\"><\/span>Fra systemisk til lokal aktivering<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3.png\" alt=\"Lokal behandling, global effekt symboliseret ved en samling af bl\u00e5 sm\u00e5 emner\" class=\"wp-image-19140\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt3-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">L\u00e6gemidlet, der har navnet 2141-V11, er en s\u00e5kaldt CD40-agonist. Det virker ved at t\u00e6nde for en kontakt (CD40-receptoren) p\u00e5 overfladen af immunceller, hvilket s\u00e6tter gang i et kraftigt immunrespons. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Tidligere fors\u00f8g med lignende stoffer har v\u00e6ret plaget af alvorlige bivirkninger, herunder leverskader og blodpropper, fordi de blev givet i blodbanen og aktiverede immunsystemet i hele kroppen p\u00e5 \u00e9n gang.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ved at udvikle en ny, mere stabil version af stoffet og spr\u00f8jte det direkte ind i tumoren, begr\u00e6nser forskerne den indledende, kraftige reaktion til et afgr\u00e6nset omr\u00e5de. <\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Inde i tumoren organiserer l\u00e6gemidlet immuncellerne i strukturer, der minder om sm\u00e5 lymfeknuder. Disse fungerer som &#8220;on-site&#8221; tr\u00e6ningslejre, hvor immunforsvarets T-celler l\u00e6rer at identificere og dr\u00e6be kr\u00e6ftcellerne. <\/li>\n\n\n\n<li>De tr\u00e6nede T-celler sendes herefter ud i blodbanen, hvor de kan finde og angribe andre tumorer i kroppen \u2013 ogs\u00e5 dem, der ikke er blevet injiceret.<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Lovende_resultater_i_forste_forsog\"><\/span>Lovende resultater i f\u00f8rste fors\u00f8g<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2.png\" alt=\"Lokal behandling, global effekt symboliseret ved nogle sm\u00e5 sorte kr\u00e6ftceller der angribes af mindre bl\u00e5 og gr\u00e5 celler.\" class=\"wp-image-19139\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt2-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Det f\u00f8rste fase 1-studie inkluderede 12 deltagere med fremskreden moderm\u00e6rkekr\u00e6ft og brystkr\u00e6ft, som ikke havde responderet p\u00e5 andre behandlinger. <\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Resultaterne var opmuntrende:<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Hos 6 ud af 12 deltagere (50 %) svandt tumorerne markant.<\/li>\n\n\n\n<li>Hos 2 af deltagerne (en med moderm\u00e6rkekr\u00e6ft og en med brystkr\u00e6ft) forsvandt alle tegn p\u00e5 kr\u00e6ft i hele kroppen. De opn\u00e5ede det, man kalder komplet remission.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\">Bivirkninger<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">De rapporterede bivirkninger var prim\u00e6rt milde og inkluderede feber og reaktioner ved indstiksstedet. Ingen af deltagerne oplevede de alvorlige bivirkninger i leveren eller blodet, som har besv\u00e6rliggjort tidligere forskning i CD40-agonister.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Nuancer_og_vejen_frem\"><\/span>Nuancer og vejen frem<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1.png\" alt=\"Lokal behandling, global effekt symboliseret ved store kugler i et laboratorie\" class=\"wp-image-19138\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt1-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Selvom resultaterne er yderst lovende, er det vigtigt at understrege, at der er tale om et meget tidligt og lille studie.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Lille deltagerantal:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Med kun 12 deltagere kan man ikke drage endelige konklusioner om behandlingens generelle effekt og sikkerhed. Resultaterne skal bekr\u00e6ftes i meget st\u00f8rre studier.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Ikke alle responderer:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Behandlingen virkede ikke p\u00e5 alle, og forskerne arbejder nu p\u00e5 at forst\u00e5, hvilke biomark\u00f8rer der kan forudsige, hvem der vil have gavn af behandlingen.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Lange udsigter:<\/strong> <\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Forskningen er nu g\u00e5et videre til fase 2-studier, hvor metoden testes p\u00e5 flere kr\u00e6ftformer, herunder:\n<ul class=\"wp-block-list\">\n<li>Bl\u00e6rekr\u00e6ft<\/li>\n\n\n\n<li>Prostatakr\u00e6ft<\/li>\n\n\n\n<li>Hjernekr\u00e6ft<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Der vil dog stadig g\u00e5 adskillige \u00e5r, f\u00f8r behandlingen eventuelt kan blive en standardmulighed p\u00e5 hospitalerne.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><span class=\"ez-toc-section\" id=\"Konklusion\"><\/span>Konklusion<span class=\"ez-toc-section-end\"><\/span><\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" src=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5.png\" alt=\"Lokal behandling, global effekt symboliseret ved turkise celler med et T skrevet i dem. I en slags r\u00f8rformet struktur.\" class=\"wp-image-19142\" style=\"object-fit:cover;width:150px;height:150px\" srcset=\"https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5.png 1024w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5-300x300.png 300w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5-100x100.png 100w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5-600x600.png 600w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5-150x150.png 150w, https:\/\/jegharkraeft.dk\/wp-content\/uploads\/2025\/08\/Lokal-behandling-global-effekt5-768x768.png 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Studiet fra Rockefeller University pr\u00e6senterer en innovativ og potentielt mere sk\u00e5nsom m\u00e5de at udnytte immunterapi p\u00e5 en den der anvendes i dag. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Ved at omdanne en enkelt tumor til en tr\u00e6ningsbase for immunforsvaret \u00e5bner forskerne for muligheden for en &#8220;global&#8221; effekt med f\u00e6rre systemiske bivirkninger.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Resultaterne er et vigtigt skridt fremad og et st\u00e6rkt signal om, at nye tilgange kan overvinde tidligere tiders forhindringer i udviklingen af kr\u00e6ftmedicin. H\u00e5bet er reelt, men det kr\u00e6ver t\u00e5lmodighed og yderligere grundig forskning at afg\u00f8re, om dette lovende koncept kan oms\u00e6ttes til en bredt anvendelig behandling.<\/p>\n\n\n\n<p class=\"has-custom-menu-links-color has-text-color has-link-color wp-elements-a7277b49cf11606a29b5c415bd565474 wp-block-paragraph\"><a href=\"#menu\">(til menu)<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\">Links<\/h4>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-bc351e71880768ffeaccb75572d5f9b1 wp-block-paragraph\"><a href=\"https:\/\/www.rockefeller.edu\/news\/38120-immunotherapy-drug-eliminates-aggressive-cancers-in-clinical-trial\/\" target=\"_blank\" rel=\"noopener\">Immunotherapy drug eliminates aggressive cancers in clinical trial <\/a>(Rockefeller University, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Indhold: Pressemeddelelse, der bekr\u00e6fter resultaterne fra det f\u00f8rste fase 1-fors\u00f8g. De fremh\u00e6ver, at hos 6 ud af 12 patienter svandt tumorerne, og hos to forsvandt kr\u00e6ften helt.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-fe6b44913e4e8215c1306b970bb2a611 wp-block-paragraph\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1535610825003198\" target=\"_blank\" rel=\"noopener\">Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer<\/a> (Science Direct, 2025)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-6c2491b94e40928a267a0a976454f6ad\">Indhold: Et nyt l\u00e6gemiddel, 2141-V11, har i et tidligt fors\u00f8g vist sig b\u00e5de sikkert og effektivt. Ved at injicere det direkte i \u00e9n tumor, aktiveredes et immunrespons i hele kroppen, som fik tumorer til at svinde ind hos patienter med fremskreden kr\u00e6ft.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-2b57301c2a2a4505fc451d079e4fc06f wp-block-paragraph\"><a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11177954\/\" target=\"_blank\" rel=\"noopener\">Intratumoral Fc-optimized agonistic CD40 antibody induces tumor rejection and systemic antitumor immunity in patients with metastatic cancer<\/a> (PubMed, 2024 &#8211; This is a preprint. <strong>It has not yet been peer reviewed by a journal<\/strong>)<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Indhold: Den oprindelige og mest detaljerede kilde er selve den videnskabelige artikel, som er publiceret i tidsskriftet <em>Cancer Cell<\/em>. Den kan findes i National Library of Medicine (PubMed Central) og indeholder alle data og den fulde analyse fra fase 1-studiet. Her bekr\u00e6ftes det, at l\u00e6gemidlet var veltolereret og viste effekt mod b\u00e5de de injicerede tumorer og tumorer andre steder i kroppen.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-c3a4b7a4686fab280a3d750c01eb2001 wp-block-paragraph\"><a href=\"https:\/\/www.cancer.gov\/research\/participate\/clinical-trials\/intervention\/fc-engineered-anti-cd40-agonist-antibody-2141-v11?pn=1\" target=\"_blank\" rel=\"noopener\">Clinical Trials Using Fc-engineered Anti-CD40 Agonist Antibody 2141-V11<\/a> (National Cancer Institute (NCI))<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Indhold: Det amerikanske nationale kr\u00e6ftinstitut bekr\u00e6fter eksistensen og virkningsmekanismen af l\u00e6gemidlet, som de beskriver som &#8220;Fc-engineered anti-CD40 agonist antibody 2141-V11&#8221;. <br>De har ogs\u00e5 en oversigt over igangv\u00e6rende kliniske fors\u00f8g med 2141-V11, hvilket viser, at forskningen er g\u00e5et videre til fase 2 og nu unders\u00f8ges p\u00e5 flere kr\u00e6fttyper, herunder bl\u00e6re-, prostata- og hjernekr\u00e6ft (gliom). Dette underbygger de lovende indledende resultater.<\/li>\n<\/ul>\n\n\n\n<p class=\"has-custom-sort-tekst-color has-text-color has-link-color wp-elements-ab3bd82cfa60ac4077e7ec0becb063e4 wp-block-paragraph\"><a href=\"https:\/\/aacrjournals.org\/cancerres\/article\/85\/8_Supplement_2\/CT203\/761855\/Abstract-CT203-Fc-optimized-anti-CD40-agonist\" target=\"_blank\" rel=\"noopener\">Abstract CT203: Fc-optimized anti-CD40 agonist antibody 2141-V11 for BCG-unresponsive non-muscle invasive bladder cancer: Updates on phase 1 study clinical outcomes and biological correlatives <\/a>(American Association for Cancer Research (AACR))<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Indhold: Resultater fra et fors\u00f8g med 2141-V11 til behandling af bl\u00e6rekr\u00e6ft, pr\u00e6senteret ved American Association for Cancer Research (AACR), viste ogs\u00e5 positive resultater, hvor en betydelig andel af patienterne opn\u00e5ede &#8220;complete response&#8221;, alts\u00e5 at kr\u00e6ften forsvandt.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Siden oprettet:<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">d. 18.08.25<\/p>\n\n\n\n<p class=\"has-text-align-center wp-block-paragraph\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-custom-menu-links-color\">\u2764<\/mark><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Hvad du l\u00e6ser p\u00e5 <\/strong><em><strong>Jeg har Kr\u00e6ft<\/strong><\/em><strong> er ikke en anbefaling. S\u00f8g kompetent vejledning.<\/strong><\/p>\n<\/div>\n<\/div>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_83 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Indhold<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Nyeste\" >Nyeste<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-1'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Lokal_behandling_global_effekt_%E2%80%93_Ny_immunterapi_fjerner_kraeft_i_forsog\" >Lokal behandling, global effekt &#8211; Ny immunterapi fjerner kr\u00e6ft i fors\u00f8g<\/a><ul class='ez-toc-list-level-2' ><li class='ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Et_nyt_immunterapeutisk_princip\" >Et nyt immunterapeutisk princip<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Fra_systemisk_til_lokal_aktivering\" >Fra systemisk til lokal aktivering<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Lovende_resultater_i_forste_forsog\" >Lovende resultater i f\u00f8rste fors\u00f8g<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Nuancer_og_vejen_frem\" >Nuancer og vejen frem<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/jegharkraeft.dk\/en\/lokal-behandling-global-effekt\/#Konklusion\" >Konklusion<\/a><\/li><\/ul><\/li><\/ul><\/nav><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Nyeste Forskning Lokal behandling, global effekt &#8211; Ny immunterapi fjerner kr\u00e6ft i fors\u00f8g Kilde: Fc-optimized CD40 agonistic antibody elicits tertiary lymphoid structure formation and systemic antitumor immunity in metastatic cancer (Science Direct, 2025) Immunotherapy drug eliminates aggressive cancers in clinical trial (Rockefeller University, 2025) Resum\u00e9 Imponerende resultat: Et nyt eksperimentelt l\u00e6gemiddel, 2141-V11, har vist bem\u00e6rkelsesv\u00e6rdige [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":19137,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[20],"tags":[],"class_list":["post-19136","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-forskning"],"modified_by":"Hanne","wpml_current_locale":"da_DK","wpml_translations":[],"_links":{"self":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/19136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/comments?post=19136"}],"version-history":[{"count":0,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/posts\/19136\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media\/19137"}],"wp:attachment":[{"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/media?parent=19136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/categories?post=19136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/jegharkraeft.dk\/en\/wp-json\/wp\/v2\/tags?post=19136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}